ocal Responses to Food Allergens in Eosinophilic Esophagitis: Mechanisms and Clinical Applicatio

Completed

Conditions: allergic esophagitis
Eosinophilic esophagitis
10017969
10001708

Registration Number: NL-OMON49025

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 18

Inclusion Criteria

Eosinophilic esophagitis patients
- Previous diagnosis of active EoE confirmed by histopathology e.g. presence of
> 15 eosinophilic granulocytes per high power field (hpf) in mid or proximal
esophageal biopsies
- Written informed consent
- Age 18-75 years

Non- eosinophilic esophagitis patients
- Patients that undergo a gastroscopy for other indications than esophageal
complaints
- Written informed consent
- Age 18 * 75 years

Exclusion Criteria

Eosinophilic esophagitis patients
- Inability to stop topical corticosteroids
- Inability to stop beta-blockers and ACE inhibitors
- Use of oral or systemic antihistaminics, oral cromoglicates, systemic
corticosteroids, leukotriene inhibitors, or monoclonal antibodies, in the month
preceding the study
- Proven gastroesophageal reflux disease or other cause for esophageal
eosinophilia
- History of peptic ulcer disease
- History of Barrett*s esophagus
- History of GI cancer
- ASA class III, IV or V
- History of anaphylaxis
- History of a severe systemic reaction to previous allergy tests (grade 3 or 4)

Non- eosinophilic esophagitis patients
- Symptoms of esophageal dysfunction
- History of esophageal diseases

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p> Visible response to allergen provocation in the esophagus, defined as early<br /><br>phase response </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1. Immune response after allergen injection and flush of allergens, defined as<br /><br>activated immune cells observed in biopsies<br /><br>2. Immune response to added allergens of esophageal mucosal cells in culture<br /><br>medium, defined as release of cytokines<br /><br>3. Esophageal motility changes after allergen exposure</p><br>