The Effect of Oral Magnesium as co-analgesics on Postoperative Pain after Wisdom tooth removal

Phase 4

Active, not recruiting

• Conditions: Patient with impacted mandibular third molar on both sides of mouth.; Oral magnesium; Magnesium supplement; Analgesic adjuvant; coanalgesic; Postoperative pain; Wisdom tooth; Third molar

• Registration Number: TCTR20221003004
• Lead Sponsor: Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-10-03
• Study Completion: 2024-03-11
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Active, not recruiting
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

1. Age over 18 years old.
2. Healthy status (American Society of Anesthesiologists (ASA) Class I and II).
3. Required removal of both impacted mandibular third molar.
4. Needed bone removal and/or tooth sectioning for removal of the mandibular third molars.

Exclusion Criteria

1. History of allergy to medications used in this study.
2. Pregnancy or breast feeding.
3. History of systemic disease or conditions contraindicated to magnesium.
4. Presence of ongoing pain originated from mandibular third molar or orofacial region on the day of surgery.
5. History of analgesic intake within 1 week prior to surgery.
6. History of medication or supplement intake that can affect body magnesium level.
7. Psychiatric disorder.
8. Being unable to record postoperative outcomes and attend follow-up appointments.
9. Presence of signs and symptoms of local and/or systemic infection or associated pathology.
10. Removal of more than one third molar at the same sitting.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Postoperative pain intensity at rest 6, 24, 48, and 72 hours after third molar surgery Heft-Parker visual analog scale,Postoperative pain intensity on jaw movement 6, 24, 48, and 72 hours after third molar surgery Heft-Parker visual analog scale

Secondary Outcome Measures

Name	Time	Method
The number of analgesic consumptions after surgery at specific time 1 week after surgery Patient reported outcome using a questionnaire and pill count,Composite of adverse events from magnesium intake 1 week after surgery Patient reported outcome using a questionnaire