NCT03106220终止不适用
Exercise Intervention and Its Impact on Hospitalization - a Mulitcentered Study
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- Mayo Clinic
- 入组人数
- 19
- 试验地点
- 3
- 主要终点
- 6MWT
研究概览
简要总结
Skeletal muscle abnormalities (sarcopenia) and frailty are common complications seen in patients with end-stage liver disease. The presence of these complications portends poor prognosis. The purpose of this study is to assess the impact of a formal home based video strengthening program (REST) on sarcopenia and frailty. We also want to assess the impact of this exercise program on complication rates, hospitalization, on quality of life (QOL) and on survival.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •inclusion= waitlisted for liver transplant with poor 6MWT
排除标准
- •include: age < 18 years, recent hospitalization (within 14 days) due to decompensation, variceal bleeding in the previous 1 month, large esophageal varices without primary prophylaxis, active excessive alcohol intake (in the previous 3 months), current overt uncontrolled hepatic encephalopathy, hepatopulmonary syndrome with uncontrolled hypoxia, portopulmonary hypertension, inability to perform exercise, or marked symptomatic comorbidities (cardiac, pulmonary, renal). multiorgan transplant
研究组 & 干预措施
home exercise
Active Comparator
participate in home exercise program
干预措施: exercise (Behavioral)
standard care
Placebo Comparator
encouraged to join physical therapy and walking goals
干预措施: placebo (Other)
结局指标
主要结局
6MWT
时间窗: 3 months
6 minute walk
hand grip
时间窗: 3 months
hand grip
次要结局
未报告次要终点
研究者
研究点 (3)
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