Diet Intervention in Food Sensitive Patients With IgA Nephropathy
Not Applicable
- Conditions
- IGA Nephropathy
- Interventions
- Dietary Supplement: Tailored dietDietary Supplement: Low antigen content diet
- Registration Number
- NCT01203007
- Lead Sponsor
- Uppsala University Hospital
- Brief Summary
The purpose of this study is to assess whether a tailored diet, eliminating antigens to which IgA nephropathy patients have demonstrated sensitivity, will have an effect on proteinuria, renal function and other immunological variables.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
- Above 18 years
- IgA nephropathy (IgAN), verified by biopsy
- Proteinuria > 1 g/24 h
- Having signed informed consent form
Exclusion Criteria
- Participation in another clinical trial
- Patients with celiac disease
- Introduction of an angiotensin-converting enzyme (ACE) inhibitor or angiotensin II receptor blockers (ARB) during the last three months prior to inclusion
- Patients treated with immunosuppressive or systemic corticosteroid drugs within the last twelve months
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Tailored diet Tailored diet Tailored diet according to demonstrated food sensitivity Low-antigen content (LAC) diet Low antigen content diet Low-antigen content diet
- Primary Outcome Measures
Name Time Method Proteinuria 6 months
- Secondary Outcome Measures
Name Time Method Renal function 6 months Glomerular filtration rate (GFR)
IgA/IgG immune complexes, incl. glycosylation 6 months IgA/IgG to dietary antigens 6 months Hematuria 6 months
Trial Locations
- Locations (3)
Haukeland University Hospital
🇳🇴Bergen, Norway
Linköping University Hospital
🇸🇪Linköping, Sweden
Uppsala University Hospital
🇸🇪Uppsala, Sweden