Comparative study for stem bromelain and diclofenac sodium of early knee osteoarthritis

Phase 2

Completed

• Conditions: SF- Oxidative stress, Diclofenac, Knee osteoarthritis, WOMAC, COX- Mild to Moderate Knee Osteoarthritis; Bromelain, 2 activity; 36&#44

• Registration Number: TCTR20140424001
• Lead Sponsor: Department of Pharmacology, Faculty of Science, Mahidol University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2012-05-15
• Study Start: 2014-04-24
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

the subjects had knee pain and radiographic osteophytes appear at the margins of the joint with at least one of the following features
1 age more than or equal 50 years
2 morning stiffness less than 30 minutes
and 3 crepitus on motion

Exclusion Criteria

history of peptic ulcer
steroid or hyaluronic intra articular injection within 3 months
unable to walk
hypersensitive to NSAIDs
or concomitant use of anti inflammatory or analgesic drugs

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Total Western Ontario McMaster Osteoarthritis (WOMAC) score four weeks and sixteen weeks Questionnaire

Secondary Outcome Measures

Name	Time	Method
WOMAC’s pain, stiffness, function subscales and 36 Question Short Form Health Survey (SF-36) four weeks and sixteen weeks Questionnaire