Systemic, Intrapulmonary and Pleural Inflammatory Reaction in Patients Undergoing Thoracic Surgery

University Hospital, Basel, Switzerland1 site in 1 country15 target enrollmentApril 2007

ConditionsLung Neoplasms

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Lung Neoplasms
Sponsor: University Hospital, Basel, Switzerland
Enrollment: 15
Locations: 1
Primary Endpoint: Cytokine levels in blood, bronchial lavage fluid and pleural fluid
Status: Completed
Last Updated: 14 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Inflammatory reaction in different compartments of the body may have a negative effect on outcome. This study assesses the inflammatory reaction systemically, intrapulmonary and intrapleural by measuring different cytokines. Patients with lung cancer undergoing lobectomy or segmentectomy are included in the study. Hypothesis: The inflammatory reaction in the pleural space is high compared to the systemic and intrapulmonary ones.

Registry

clinicaltrials.gov

Start Date

April 2007

End Date

June 2011

Last Updated

14 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

University Hospital, Basel, Switzerland

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•elective lobectomy
•elective segmentectomy
•20-90 years
•informed consent given

Exclusion Criteria

•emergency operations
•pneumonectomy

Outcomes

Primary Outcomes

Cytokine levels in blood, bronchial lavage fluid and pleural fluid

Time Frame: 2 years

Correlation between cytokine levels and pulmonary morbidity

Time Frame: 2 years

Secondary Outcomes

Comparison of this collective with transthoracic esophagectomies and evaluation of the inflammatory reactions (esophageal collective registered:NCT00512265)(4 years)