‘Strength for Task Training’ to improve walking following stroke.

Not Applicable

• Conditions: Stroke; Stroke - Ischaemic; Stroke - Haemorrhagic

• Registration Number: ACTRN12610000460000
• Lead Sponsor: AUT University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-06-04
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

All people aged over 18 years with a single disabling supratentorial ischaemic stroke or intracerebral haemorrhage (Rankin 2-3); between 3-9 months post stroke at the start of the intervention; with a gait speed of between 0.05m/s -<1.2m/s at entry to the study; who are able to walk with or without aid and with or without standby assistance will be eligible for recruitment.

Exclusion Criteria

Individuals will be excluded if: (a) their behaviour would interfere with participation in a group setting, as noted during initial assessment (e.g., agitation, aggression); (b) they have a significant cognitive deficit ((Mini-Mental State Examination (MMSE) Score <23); (c)they are unable to follow a 1 step English verbal command; (d) they are unable to give informed consent; (e) they are medically unstable in the opinion of a medical clinician; (f) they are participating in another study that, in the opinion of the investigator, may affect gait speed or add significantly to participant’s burden; (g) they have excessive pain in any joint that could limit participation; or (h) they have another condition that could impact results (e.g., substance abuse, significant mental illnesses such as major depression) (i) they have any contra-indications to TMS, including pacemaker, artificial heart valves, other metal implants, pregnancy, skull abnormalities, history of seizures or epilepsy, taking medications that may lower seizure threshold, or claustrophobia.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
eural Plasticity: Cortical excitability using Transcranial Magnetic Stimulation (TMS) of the soleus muscle at 10% Maximal Voluntary Contraction to measure Active Motor Threshold, Motor Evoked Potential, Intra cortical Inhibition and Intra cortical facillitation, Input/Output curves and during the push off phase of gait to measure task specific Motor Evoked Potential, Intra cortical Inhibition and Intra cortical facillitation[Baseline<br>Post-intervention (12 weeks)];Locomotor Function measured using comfortable and fast paced gait velocity, stair ascend and descend, 30second chair stand test and the step test[Baseline<br>Post-intervention (12 weeks)];Participation using the Subjective Index of Physical and Social Outcome and the Stroke Impact Scale[Baseline<br>Post-intervention (12 weeks)]

Secondary Outcome Measures

Name	Time	Method
Recruitment numbers including the number of approached, screened and consented individuals over the recruitment phase[Post-intervention (12 weeks)];Randomised Controlled Trial Protocol Integrity including the number of completed versus scheduled intervention sessions, the number of exercise progressions over the intervention and the number of missing data points[Post-intervention (12 weeks)];Intervention acceptability including the barriers and facillitators to engaging in the rehabilitation intervention, the acceptability of the intervention and the perceived cost-benefit using semi-structured interviews[Post-intervention (12 weeks)];Muscle Strength measured using 1 Repetition Maximum leg press[Baseline <br>Post-intervention (12 weeks)];Neural Plasticity: Brain Derived Neurotrophic Factor (BDNF) measured pre, during and post a bout of submaximal exercise using blood serum levels established via Enzyme-linked immunosorbent assay (ELISA) kits[Baseline <br>Post-intervention (12 weeks)]