Analysis of Clinical Characteristics and Study of Diagnostic Markers in Patients with Polycystic Ovary Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 600
- 试验地点
- 1
- 主要终点
- diagnostic markers of PCOS patients
研究概览
简要总结
The investigators collected clinical data and serum samples of patients with polycystic ovary syndrome in this study, used statistical software such as SPSS for data analysis, and used experimental techniques such as ELISA to detect serum samples, aiming to explore the relationship between the body anthropometry, glucose and lipid metabolism, gonadal hormones and body fat distribution in patients with polycystic ovary syndrome and to discovery new biomarkers and promote the realization of more accurate personalized medicine.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Female aged 18- 45;
- •Meet Rotterdam criteria;
排除标准
- •Women who are pregnant or have a pregnancy plan within six months;
- •Congenital adrenocortical hyperplasia;
- •Hyperprolactinemia;
- •Hyperthyroidism or hypothyroidism;
- •Abnormal liver function (≥ 3 times of the upper limit of normal range);
- •Abnormal renal function (GFR<60ml/min/1.73m2);
- •Adrenal or ovarian tumors secreting androgens;
- •Used contraceptives, metformin, GLP-1RA, pioglitazone and contraceptives in the last 3 month.
结局指标
主要结局
diagnostic markers of PCOS patients
时间窗: baseline
Fibrinogen-like-protein 1 (FGL1), is a novel hepatokine that plays an important role in hepatic steatosis, insulin resistance and obesity. There is no maximum or minimum value for this parameter and the higher scores mean a worse outcome.
次要结局
- FSH(baseline)
- DHEAS(baseline)
- PINS,(baseline)
- TC(baseline)
- Interleukin 6，IL-6(baseline)
- body mass index ,BMI(baseline)
- Number of menstruation in the last year(baseline)
- RBP-4(baseline)
- adiponectin(baseline)
- HOMA-IR(baseline)
- TT(baseline)
- FT(baseline)
- SHBG(baseline)
- ALT(baseline)
- CR(baseline)
- HDL-c(baseline)
- LH(baseline)
- FBG(baseline)
- AST(baseline)
- LDL-c(baseline)
- TG(baseline)
- Chemerin(baseline)
- omentin-1(baseline)
- Apelin(baseline)
- Waist/hip Ratio,WHR(baseline)
- Ferriman-Gallwey score(baseline)
- PBG(baseline)
- FINS(baseline)
- UA(baseline)
- Tumor Necrosis Factor， TNF(baseline)
- leptin(baseline)
- resistin(baseline)
- Visfatin(baseline)
- Vaspin.(baseline)
- Interleukin 22，IL-22(baseline)
- Interleukin 8， IL-8(baseline)
研究者
Zhang Manna
Director, Principal Investigator, Clinical Professor
Shanghai 10th People's Hospital