The effect of cabergoline in infertile women on peritoneal endometriosis related dysmenorrhea, chronic pelvic pain and fertility
- Conditions
- Endometriosis in women with involuntary infertilityMedDRA version: 20.0Level: PTClassification code: 10014778Term: Endometriosis Class: 100000004872Therapeutic area: Diseases [C] - Female Urogenital Diseases and Pregnancy Complications [C13]
- Registration Number
- CTIS2022-500792-31-00
- Lead Sponsor
- Turku University Central Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- Not specified
- Target Recruitment
- 80
Females -Age 20 – 37 year -Mild or moderate endometriosis either diagnosed by surgery or ultrasound or strong clinical suspicion of peritoneal endometriosis based on NICE Guidelines -Endometriosis related pain NRS > 3 (dysmenorrhea) -Primary or secondary infertility for 1 year or more -Cause of infertility: mild or moderate endometriosis, unknown ‘ -Regular ovulatory cycles
-Body mass index more than 35 kg/m2 or less than 18 kg/m2 -Severe endometriosis defined as o> 4 cm unilateral endometrioma or bilateral endometriomas oAdhesions above the level of sacrouterine ligaments demonstrated by absent sliding sign in ultrasound examination or detected surgically oDeep invasive endometriosis of bowel -Hormonal suppression of endometriosis or hormonal contraception within 6 mo -Other diagnosed cause of infertility oOvulatory dysfunction oTubal factor (Tubal occlusion, hydrosalpinx, tubal sterilization) oUterine factor (Submucous myoma, intramural myoma > 4 cm, Uterine malformation apart from Uterus arcuatus) oMale factor oSocial infertility -Indication for IVF-treatment -Hyperprolactinemia, macroprolactinemia excluded -Unbalanced hypothyreoidism -Cardiac disorders -Pleural, pericardiac or retroperinoteal fibrosis -Liver dysfunction -Clinical depression or other phychiatric disorder -Previous malignancy -Allergy for cabergoline -Insufficient skills in Finnish, Swedish or English language
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.