Effectiveness Of HDtDCS In Cognitive And Negative Symptoms Of Schizophrenia measured Using fMRI

Phase 3

Not yet recruiting

Brief Summary: Schizophrenia is a chronic debilitating condition where the negative and cognitive symptoms cause functional impairment even after positive symptoms resolve. High definition transcranial direct current stimulation is a non invasive and cost effective neuomodulatory technique with promising results for negative and chronic symptoms of schizophrenia. HDtDCS is a technically enhanced version of tDCS giving a more focal stimulation and has a better predictive stimulation output which will be assessed on clinical rating scales and fMRI.

Recruitment & Eligibility

Inclusion Criteria

1.Diagnosis of Schizophrenia using Diagnostic Criteria for Research (DCR) of International Classification of Disease-10th edition (ICD-10, World Health Organization,1992) 2.Duration of illness to be more than or equal to two years.
3.Age between 18- 60 years of either sex 4.The Positive and Negative Syndrome Scale for Schizophrenia (PANSS) negative symptoms score of more than 15 5.Scale for Assessment of Negative Symptoms (SANS) score more than 20 6.Right-handed 7.Educated upto class VIII or above 8.Patients giving written informed consent.

Exclusion Criteria

1.Presence of co-morbid neurological or other psychiatric disorder(s).
2.Patient with co morbid substance dependence, except nicotine and caffeine.
3.Having any metallic implants/parts in body 4.Subjects who have received ECT in past 6 months.
5.Colour blind.

Primary Outcome Measures

Name	Time	Method
Reduction in scores on negative and cognitive symptoms after application of HDtDCS.	1. At baseline \| 2. At the end of 2 weeks \| 3. At the end of 4 weeks

Secondary Outcome Measures

Name	Time	Method
Change in fMRI activation of Pre Frontal Cortex using cognitive task and change in resting state functional connectivity at baseline and after application of HDtDCS.	1. At baseline

Locations (1): Central Institute Of Psychiatry
🇮🇳
Ranchi, JHARKHAND, India
Central Institute Of Psychiatry
🇮🇳Ranchi, JHARKHAND, India
Bhawna Yadav
Principal investigator
9650618113
bhawnayadav1712@gmail.com