NCT05884814RecruitingNot Applicable
Timing of Resistance Exercise, Glucose Control and Exercise Adaptations in People With Type 1 Diabetes: a Randomised-controlled Trial
Conditions
Interventions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Dasman Diabetes Institute
- Enrollment
- 54
- Locations
- 1
- Primary Endpoint
- Change in muscle strength
Study Overview
Brief Summary
The aims of the current study are
- to compare the effects of acute morning and afternoon resistance exercise on blood glucose levels in people with type 1 diabetes.
- to compare the effects of morning and afternoon resistance exercise training on cardiometabolic health outcomes in people with type 1 diabetes
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 21 Years to 60 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Physician confirmed type 1 diabetes for at least 1 year
- •Stable insulin therapy for 3 months prior to the study
Exclusion Criteria
- •BMI of 45 or higher
- •BP of 160/100mmHg or higher
- •autonomic neuropathy
- •severe proliferative retinopathy
- •joint or limb injuries preventing weight-bearing activity
- •autonomic neuropathy
- •severe proliferative retinopathy
- •any other medical condition that prevents participants from exercising safely.
Arms & Interventions
Control
Placebo Comparator
Habitual physical activity
Intervention: Habitual physical activity levels (Behavioral)
Morning exercise
Active Comparator
Exercise training between 6-10am
Intervention: Morning exercise (Behavioral)
Afternoon exercise
Active Comparator
Exercise training between 4-8pm
Intervention: Afternoon exercise (Behavioral)
Outcomes
Primary Outcomes
Change in muscle strength
Time Frame: Change from baseline to 12 weeks
Sum of one repetition maximum for the 7 resistance exercise
Change in interstitial glucose time in range
Time Frame: Change from 6 hours before (baseline) to 6 hours after (post-exercise) an exercise training session
Interstitial glucose time in range (3.9-10mmol/L) measured via continuous glucose monitoring
Secondary Outcomes
- Change in interstitial glucose average(Change from 6 hours before (baseline) to 6 hours after (post-exercise) an exercise training session)
- Change in appendicular skeletal muscle mass(Change from baseline to 12 weeks)
- Change in whole body fat mass(Change from baseline to 12 weeks)
- Change in interstitial glucose time in hyperglycaemia(Change from 6 hours before (baseline) to 6 hours after (post-exercise) an exercise training session)
- Change in HbA1c(Change from baseline to 12 weeks)
- Change in interstitial glucose time in hypoglycaemia(Change from 6 hours before (baseline) to 6 hours after (post-exercise) an exercise training session)
- Change in physical function(Change from baseline to 12 weeks)
- Change in interstitial glucose variability(Change from 6 hours before (baseline) to 6 hours after (post-exercise) an exercise training session)
Investigators
Dr. Ebaa Al Ozairi
Chief Medical Officer
Dasman Diabetes Institute
Study Sites (1)
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