Timing of Resistance Exercise in Type 1 Diabetes

Not Applicable

Recruiting

• Conditions: Type 1 Diabetes
• Interventions: Behavioral: Morning exercise; Behavioral: Habitual physical activity levels; Behavioral: Afternoon exercise

• Registration Number: NCT05884814
• Lead Sponsor: Dasman Diabetes Institute

Brief Summary

The aims of the current study are

1. to compare the effects of acute morning and afternoon resistance exercise on blood glucose levels in people with type 1 diabetes.

2. to compare the effects of morning and afternoon resistance exercise training on cardiometabolic health outcomes in people with type 1 diabetes

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-05-10
• Study First Submitted QC: 2023-05-22
• Study First Posted: 2023-06-01
• Status Verified: 2023-07
• Study Start: 2023-07-01
• Last Update Submitted: 2023-07-27
• Last Update Posted: 2023-07-28
• Primary Completion: 2024-12-31
• Study Completion: 2024-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 54

Inclusion Criteria

• Physician confirmed type 1 diabetes for at least 1 year
• Stable insulin therapy for 3 months prior to the study

Exclusion Criteria

• BMI of 45 or higher
• BP of 160/100mmHg or higher
• autonomic neuropathy
• severe proliferative retinopathy
• joint or limb injuries preventing weight-bearing activity
• autonomic neuropathy
• severe proliferative retinopathy
• any other medical condition that prevents participants from exercising safely.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Morning exercise	Morning exercise	Exercise training between 6-10am
Control	Habitual physical activity levels	Habitual physical activity
Afternoon exercise	Afternoon exercise	Exercise training between 4-8pm

Primary Outcome Measures

Name	Time	Method
Change in muscle strength	Change from baseline to 12 weeks	Sum of one repetition maximum for the 7 resistance exercise
Change in interstitial glucose time in range	Change from 6 hours before (baseline) to 6 hours after (post-exercise) an exercise training session	Interstitial glucose time in range (3.9-10mmol/L) measured via continuous glucose monitoring

Secondary Outcome Measures

Name	Time	Method
Change in physical function	Change from baseline to 12 weeks	Measured by the short performance physical battery
Change in interstitial glucose average	Change from 6 hours before (baseline) to 6 hours after (post-exercise) an exercise training session	Interstitial average glucose measured via continuous glucose monitoring
Change in appendicular skeletal muscle mass	Change from baseline to 12 weeks	Measured by DEXA
Change in whole body fat mass	Change from baseline to 12 weeks	Measured by DEXA
Change in interstitial glucose time in hyperglycaemia	Change from 6 hours before (baseline) to 6 hours after (post-exercise) an exercise training session	Interstitial glucose time in range (\>10mmol/L) measured via continuous glucose monitoring
Change in HbA1c	Change from baseline to 12 weeks	HbA1c concentration
Change in interstitial glucose time in hypoglycaemia	Change from 6 hours before (baseline) to 6 hours after (post-exercise) an exercise training session	Interstitial glucose time in range (\<3.9mmol/L) measured via continuous glucose monitoring
Change in interstitial glucose variability	Change from 6 hours before (baseline) to 6 hours after (post-exercise) an exercise training session	Interstitial glucose variability measured via continuous glucose monitoring

Trial Locations

Locations (1)

Dasman Diabetes Institute; 🇰🇼 Kuwait City, Kuwait