Circuit-Based Deep Brain Stimulation for Parkinson's Disease; Udall Project 1 Aim 2 and 3
Completed
- Conditions
- Parkinson Disease
- Interventions
- Device: Stimulation
- Registration Number
- NCT03079037
- Lead Sponsor
- University of Minnesota
- Brief Summary
This study will test the hypothesis that deep brain stimulation (DBS) targeting specific changes in oscillatory activity at the site of stimulation will prove superior to continuous isochronal DBS thus providing the rationale for development and optimization of closed loop paradigms and determine whether the optimal closed-loop biomarker varies across subcortical targets, is task dependent, or serves to re-establish a default network that removes an underlying disruptive physiological state leading to greater improvement in motor signs and task performance.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 15
Inclusion Criteria
- Diagnosis of idiopathic PD
- DBS surgery or IPG battery replacement at UMN is planned as part of routine clinical care.
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Exclusion Criteria
- Other significant neurological disorder
- History of dementia
- Prior history of stereotactic neurosurgery
- Patients with post-operative complications or adverse effects (e.g. ON stimulation dystonias) that affect patient safety or confound the experiment will be excluded from further study
- Pregnant women
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Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Stimulation Stimulation Traditional deep brain stimulation
- Primary Outcome Measures
Name Time Method Measure local field potential (LFP) changes in subthalamic nucleus (STN) and globus pallidus (GP) in OFF and ON states of stimulation and medication 2 days Clinical ratings scales (MDS-UPDRS)
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University of Minnesota Medical Center
🇺🇸Minneapolis, Minnesota, United States