Effect of Continuous Pre-peritoneal Wound Infiltration Versus Epidural Analgesia on Inflammatory Response and Pain Following Radical Cytsectomy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- changes in the level of inflammatory cytokines in pg /ml
研究概览
简要总结
the investigators aim is to investigate the effect of continuous preperitoneal bupivacaine wound infiltration versus epidural analgesia on the inflammatory cytokines response following radical cytectomy
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Health Services Research
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ASA I-III patients
- •aged 18-60 yr
- •undergo open abdominal cancer surgery
排除标准
- •general contraindications for epidural analgesia,
- •recent history (8 weeks) of, chemotherapy or radiation,
- •chronic opioid use
研究组 & 干预措施
epidural group
an epidural catheter will be inserted under sterile conditions through the T9- 12 interspace using the 'loss-of-resistance' technique. The catheter will be advanced 4 cm cephalad. .
干预措施: epidural catheter (Device)
preperitoneal group
preperitoneal catheters will be placed in the subfascial (ie, pre-peritoneal) space under direct vision.
干预措施: preperitoneal catheter (Device)
结局指标
主要结局
changes in the level of inflammatory cytokines in pg /ml
时间窗: 24 hours
Blood samples taken all over the 24-hr. period were collected in plasma tubes containing ethyl-enediamine-tetra-acectic (EDTA), centrifuged and stored at 20○c for assessment of Plasma concentrations plasma IL 1, IL 6, IL10 and TNF to assess inflammatory cytokines
次要结局
- patient satisfaction(24 hours)
- Visual Analog Scale at rest and on coughing(24 hours)
- opioid side-effects(24 hours)
研究者
Fatma Adel El sherif,MD
lecturer of anesthesia ,icu and pain management
Assiut University