Effects of discontinuation of levothyroxine treatment in older adults: a self-controlled study

ZonMW HGOG0 个研究点目标入组 360 人开始时间: 待定最近更新: 2024年6月11日

试验速览

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•In order to be eligible to participate in this study, a subject must meet all of the following criteria:
•1) Aged 60 years or over (= 60 years)
•2) Using any levothyroxine mono-therapy medicament (ATC: H03AA01) continuously for a minimum of 1 year with stable dose of levothyroxine.

•A potential subject who meets any of the following criteria will be excluded from participation in this study:
•1) Last measurement of TSH =10 mU/L during levothyroxine treatment
•2) Current reason for levothyroxine treatment: patients with history of thyroidectomy; radioactive iodine treatment or neck irradiation; congenital hypothyroidism; secondary hypothyroidism, or concurrent amiodarone or lithium use
•3) Dose of treatment; for safety issues, patients using > 150 mcg levothyroxine per day (0.48%) will not be eligible
•4) Diagnosis of heart failure NYHA grade IV
•5) Participation in ongoing trials of therapeutic interventions
•6) Life-expectancy of less than 6 months
•7) Diagnosis of dementia
•8) Incapacitated adults
•9) Persons that plan to move out of the region in which the study is being conducted in the next months.

发起方

ZonMW HGOG