A Study of the Efficacy and Safety of Risankizumab in Participants With Crohn's Disease
- Conditions
- Crohn's Disease
- Interventions
- Drug: Placebo for Risankizumab SCDrug: Placebo for Risankizumab IVDrug: Risankizumab SCDrug: Risankizumab IVDrug: Risankizumab On-Body Injector (OBI)
- Registration Number
- NCT03105102
- Lead Sponsor
- AbbVie
- Brief Summary
The study consists of 4 sub-studies, as follows:
* Sub-study 1 (Randomized, double-blind, placebo controlled study) to evaluate the efficacy and safety of risankizumab versus placebo as maintenance therapy in participants with moderately to severely active Crohn's disease (CD) who responded to intravenous risankizumab induction treatment in Study M16-006 or Study M15-991;
* Sub-study 2 (Randomized, exploratory maintenance study) to evaluate the efficacy and safety of two different dosing regimens for risankizumab as maintenance therapy in participants who responded to induction treatment in Study M16-006 or Study M15-991;
* Sub-study 3 (Open-label, long-term extension study) to evaluate long-term safety of risankizumab in participants who completed Sub-study 1, Sub-study 2, another AbbVie risankizumab Crohn's disease study, or participants who responded to induction treatment in Study M16-006 or Study M15-991 with no final endoscopy due to the Covid-19 pandemic. Additional objectives are to further investigate long-term efficacy and tolerability of risankizumab;
* Sub-study 4 (Open-label On Body Injector (OBI) administration and long-term extension study) to evaluate patient-reported outcomes, efficacy, safety, tolerability, and pharmacokinetics of risankizumab administered via OBI in participants who are receiving maintenance treatment with risankizumab.
* OL CTE to ensure uninterrupted care in accordance with local regulations until risankizumab is commercially available for participants who completed Sub-study 3, Sub-study 4.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 1336
-
Participants who have entered and completed Study M16-006 or Study M15-991 or other AbbVie risankizumab Crohn's disease study.
-
Participants have completed the study M16-006 or M15-991 and have achieved clinical response.
-
Sub-Study 4:
- Participants receiving maintenance treatment in Sub-study 3 and willing to comply with the requirements of Sub-study 4, including self-administration of sub-cutaneous injections using the on-body injector (OBI).
- Participant has received at least 16 weeks of stable dosing with risankizumab in Sub-study 3 (i.e., no rescue within 16 weeks and participant has surpassed the 72-week mark).
- Participants should not be enrolled in Study M16-000 with high grade colonic dysplasia or colon cancer identified during Study M15-991, Study M16-006 or another AbbVie risankizumab Crohn's disease study if the final endoscopy was performed prior to enter Study M16-000 OR is considered by the Investigator, for any reason, to be an unsuitable candidate for the study.
- Participant who has a known hypersensitivity to risankizumab or the excipients of any of the study drugs or the ingredients of Chinese hamster ovary (CHO), OR had an adverse event (AE) during Studies M16-006, M15-991 or another AbbVie risankizumab Crohn's disease study that in the Investigator's judgment makes the participant unsuitable for this study.
- Participant is not in compliance with prior and concomitant medication requirements throughout Studies M16-006, M15-991 or another AbbVie risankizumab Crohn's disease study.
- Confirmed positive urine pregnancy test at the Final Visit of Study M16-006, Study M15-991 or another AbbVie risankizumab Crohn's disease study.
- Have a known history of lymphoproliferative disease, including lymphoma, or signs and symptoms suggestive of possible lymphoproliferative disease, such as lymphadenopathy and/or splenomegaly.
- Any active or chronic recurring infections based on the Investigator's assessment makes the participant an unsuitable candidate for the study.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Double-blind Placebo for Risankizumab (Sub-Study 1) Placebo for Risankizumab SC Participants randomized to receive double-blind placebo for risankizumab for 52 weeks. Maintenance Risankizumab Dose 1 (Sub-Study 2) Placebo for Risankizumab IV Participants will receive double-blind subcutaneous (SC)risankizumab dose 1 and intravenous placebo at Week 0 followed by open-label SC risankizumab dose 1 from Week 8 through Week 52. Maintenance Risankizumab Dose 2 (Sub-Study 2) Placebo for Risankizumab SC Participants will receive double-blind subcutaneous placebo and intravenous risankizumab dose 3 at Week 0 followed by open-label SC risankizumab dose 1 from Week 8 through Week 52. Double-blind Risankizumab Dose 1 (Sub-Study 1) Risankizumab SC Participants randomized to receive double-blind risankizumab dose 1 for 52 weeks. Double-blind Risankizumab Dose 2 (Sub-Study 1) Risankizumab SC Participants randomized to receive double-blind risankizumab dose 2 for 52 weeks. Maintenance Risankizumab Dose 1 (Sub-Study 2) Risankizumab SC Participants will receive double-blind subcutaneous (SC)risankizumab dose 1 and intravenous placebo at Week 0 followed by open-label SC risankizumab dose 1 from Week 8 through Week 52. Maintenance Risankizumab Dose 2 (Sub-Study 2) Risankizumab IV Participants will receive double-blind subcutaneous placebo and intravenous risankizumab dose 3 at Week 0 followed by open-label SC risankizumab dose 1 from Week 8 through Week 52. Maintenance Risankizumab Dose 2 (Sub-Study 2) Risankizumab SC Participants will receive double-blind subcutaneous placebo and intravenous risankizumab dose 3 at Week 0 followed by open-label SC risankizumab dose 1 from Week 8 through Week 52. Open-label Risankizumab (Sub-Study 3) Risankizumab SC Participants who completed Sub-study 1 or Sub-study 2 or other AbbVie risankizumab Crohn's disease study or M16-006 or M15-991 without endoscopy will receive open-label risankizumab dose 1 or dose 2 depending on their preceding study beginning at Week 56. Risankizumab On-Body Injector and Open Label (Sub-Study 4) Risankizumab SC Participants in Sub-study 3 who meet eligible criteria for Sub-study 4 will receive risankizumab dose 1 or dose 2 via on-body injectors on Weeks 0,8 and 16. Beginning Week 24, participants will receive risankizumab dose 1 or dose 2 via pre-filled syringes Q8W. Risankizumab On-Body Injector and Open Label (Sub-Study 4) Risankizumab On-Body Injector (OBI) Participants in Sub-study 3 who meet eligible criteria for Sub-study 4 will receive risankizumab dose 1 or dose 2 via on-body injectors on Weeks 0,8 and 16. Beginning Week 24, participants will receive risankizumab dose 1 or dose 2 via pre-filled syringes Q8W. CTE: Open Label Continuous Treatment Extension Risankizumab SC Participants who tolerate and derive benefit from receiving risankizumab and complete Sub-study 3 or Sub-study 4 will receive risankizumab dose 1 or dose 2 Q8W.
- Primary Outcome Measures
Name Time Method Sub-Study 1: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Remission Week 52 The CDAI is used to evaluate disease activity in patients with Crohn's disease. The CDAI clinical remission is defined as a CDAI score of \< 150.
Sub-Study 1: Percentage of Participants With Endoscopic Response Week 52 Endoscopic response defined as decrease from Baseline of the induction study in Simple Endoscopic Score for Crohn's Disease (SES-CD).
Sub-Study 3: Number of Participants With Adverse Events Up to Week 220 An adverse event (AE) is defined as any untoward medical occurrence in a patient or clinical investigation subject administered a pharmaceutical product and which does not necessarily have a causal relationship with this treatment. The investigator assessed the relationship of each event to the use of study drug as either probably related, possibly related, probably not related or not related. A serious adverse event (SAE) is an event that results in death, is life-threatening, requires or prolongs hospitalization, results in a congenital anomaly, persistent or significant disability/incapacity or is an important medical event that, based on medical judgment, may jeopardize the subject and may require medical or surgical intervention to prevent any of the outcomes listed above. Treatment-emergent AEs are defined as any event that began or worsened in severity after the first dose of study drug. For more details on adverse events please see the Adverse Event section.
Sub-Study 4: Percentage of Participants With an Observer Rating of Successful Participant Self Administration Up to Week 16 Participant who successfully completed the sequence of critical steps in the instructions for use (IFU) without errors to administer study drug via the OBI at Week 0 and 16.
Sub-Study 4: Percentage of Participants who had no Potential Hazards Up to Week 16 Measured by an observer on the possible use-related hazards checklist for self-administration with OBI at Week 0 and Week 16.
Sub-Study 4: Percentage of Participants Rating of Acceptability Using Self-Injection Assessment Questionnaire (SIAQ) at Weeks 0, 8, 16 Up to Week 16 SIAQ evaluations consist of the PRE module, which is self-completed immediately before the first OBI self-injection at baseline, and the POST module, which is self-completed 20 to 40 min following injections at Weeks 0, 8, 16. These modules are completed by participants while alone in a quiet environment.
Participants rate each item of the SIAQ. The ratings are later transformed to scores ranging from 0 (worst experience) to 10 (best experience). The domain score is the mean of the item scores included in the domain. Domain scores are calculated only if at least half of the domain items are completed. Item and domain scores from the PRE module are compared with the corresponding item and domain scores from the POST modules.Sub-Study 4: Percentage of Participants in CDAI Clinical Remission at Week 0, 16 Up to Week 16 Clinical remission per average daily stool frequency (SF) and average daily abdominal pain (AP) score.
- Secondary Outcome Measures
Name Time Method Sub-Study 1: Percentage of Participants With Clinical Remission Week 52 Clinical remission per average daily stool frequency (SF) and average daily AP score.
Sub-Study 1: Percentage of Participants With CDAI Clinical Remission Among Participants With CDAI Clinical Remission in Week 0 Week 52 The CDAI is used to evaluate disease activity in patients with Crohn's disease
Sub-Study 1: Percentage of Participants With Ulcer-Free Endoscopy Week 52 Endoscopic healing was assessed using SES-CD.
Sub-Study 1: Percentage of Participants With Endoscopic Remission Week 52 Endoscopic Remission is defined as SES-CD \<= 4 and at least a 2 point reduction versus baseline and no subscore greater than 1 in any individual variable, as scored by a central reviewer
Sub-Study 1: Change From Baseline of Induction in Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue) Week 52 The FACIT-Fatigue is a validated tool that measures an individual's level of fatigue during their usual daily activities over the past week.
Sub-Study 1: Percentage of Participants Who Discontinued Corticosteroid Use for 90 Days and Achieved Clinical Remission in Participants Taking Steroids at Baseline Week 52 Participants who discontinued corticosteroid use and achieved clinical remission per average daily SF and average daily AP score.
Sub-Study 1: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Response Week 52 The CDAI is used to evaluate disease activity in patients with Crohn's disease.
Sub-Study 1: Percentage of Participants With Stool Frequency (SF) Remission Week 52 SF Remission is defined by an average daily SF \<= 2.8 and not worse than baseline.
Sub-Study 1: Percentage of Participants With Abdominal Pain (AP) Remission Week 52 AP Remission is defined by an average daily AP \<= 1 and not worse than baseline.
Sub-Study 1: Percentage of Participants With CDAI Clinical Remission and Endoscopic Response Week 52 The CDAI is used to evaluate disease activity in patients with Crohn's disease. The CDAI clinical remission is defined as a CDAI score of \< 150. Endoscopic response defined as decrease from baseline of \> 50% of the induction study in Simple Endoscopic Score for Crohn's Disease (SES-CD).
Sub-Study 1: Percentage of Participants With Deep Remission Week 52 Deep remission defined as participants with both clinical remission (per average daily SF and average daily AP score) and endoscopic remission (assessed using SES-CD).
Sub-Study 1: Percentage of Participants With Exposure Adjusted Occurrence of CD-related Hospitalizations From Week 0 Through Week 52 Up to Week 52 Participants with an event that results in admission to the hospital.
Trial Locations
- Locations (496)
Guangdong Provincial People's Hospital /ID# 212949
🇨🇳Guangzhou, Guangdong, China
Akershus Universitetssykehus /ID# 169379
🇳🇴Nordbyhagen, Akershus, Norway
Fundeni Clinical Institute /ID# 170899
🇷🇴Bucharest, Romania
Tvm Med Serv Srl /Id# 170902
🇷🇴Cluj, Romania
Duplicate_Centrul Medical Tuculanu SRL /ID# 170903
🇷🇴Timisoara, Romania
Cabinet Particular Policlinic Algomed /ID# 170900
🇷🇴Timișoara, Romania
National University Hospital /ID# 160667
🇸🇬Singapore, Singapore
Digestive Disease Consultants, A Division of Arizona Digestive Health, P.C /ID# 211884
🇺🇸Mesa, Arizona, United States
Phoenix VA Health Care System /ID# 162264
🇺🇸Phoenix, Arizona, United States
University of Arizona /ID# 158502
🇺🇸Tucson, Arizona, United States
Atria Clinical Research /ID# 164505
🇺🇸Little Rock, Arkansas, United States
Southern California Res. Ctr. /ID# 211991
🇺🇸Coronado, California, United States
Duplicate_Newport Huntington Medical Group /ID# 213035
🇺🇸Huntington Beach, California, United States
UC San Diego Health Systems /ID# 155555
🇺🇸La Jolla, California, United States
United Medical Doctors /ID# 207888
🇺🇸Los Alamitos, California, United States
TLC Clinical Research Inc /ID# 212719
🇺🇸Los Angeles, California, United States
Gastrointestinal Biosciences Clinical Trials, LLC /ID# 162657
🇺🇸Los Angeles, California, United States
United Medical Doctors - Murrieta /ID# 158300
🇺🇸Murrieta, California, United States
University of California San Francisco - Mission Bay /ID# 157127
🇺🇸San Francisco, California, United States
Duplicate_Cedars-Sinai Medical Center-West Hollywood /ID# 163839
🇺🇸West Hollywood, California, United States
Peak Gastroenterology Associates, PC /ID# 165843
🇺🇸Colorado Springs, Colorado, United States
Rocky Mountain Pediatric Gastroenterology /ID# 207170
🇺🇸Lone Tree, Colorado, United States
Duplicate_Western Connecticut Medical Group /ID# 165879
🇺🇸Danbury, Connecticut, United States
Brandon Premier Health Care, PA/Gulf Coast Research Group, LLC /ID# 162262
🇺🇸Brandon, Florida, United States
South Lake Pain Institute, Inc /ID# 162808
🇺🇸Clermont, Florida, United States
Omega Research Maitland, LLC /ID# 171082
🇺🇸DeBary, Florida, United States
Universal Axon Clinical Research /ID# 165428
🇺🇸Doral, Florida, United States
Nature Coast Clinical Research - Inverness /ID# 159408
🇺🇸Inverness, Florida, United States
SIH Research Mumtaz, Inc /ID# 163083
🇺🇸Kissimmee, Florida, United States
Alliance Medical Research /ID# 163837
🇺🇸Lighthouse Point, Florida, United States
Cfagi Llc /Id# 202479
🇺🇸Maitland, Florida, United States
Sylvester Comprehensive Cancer Center /ID# 155007
🇺🇸Miami, Florida, United States
Coral Research Clinic /ID# 158456
🇺🇸Miami, Florida, United States
South Florida Research Ph I-IV, Inc. /ID# 161832
🇺🇸Miami, Florida, United States
Gastroenterology Group Naples /ID# 165204
🇺🇸Naples, Florida, United States
Advanced Research Institute, Inc /ID# 161966
🇺🇸New Port Richey, Florida, United States
Endoscopic Research, Inc. /ID# 205906
🇺🇸Orlando, Florida, United States
IMIC Inc. Medical Research /ID# 154942
🇺🇸Palmetto Bay, Florida, United States
Clinical Research of West Florida, Inc /ID# 205865
🇺🇸Tampa, Florida, United States
Clinical Research of West Florida, Inc /ID# 208125
🇺🇸Tampa, Florida, United States
Atlanta Gastro Assoc /ID# 154724
🇺🇸Atlanta, Georgia, United States
Gastroenterology Associates of Central Georgia, LLC /ID# 154850
🇺🇸Macon, Georgia, United States
Duplicate_Northwestern University /ID# 158261
🇺🇸Chicago, Illinois, United States
The University of Chicago Medical Center /ID# 157124
🇺🇸Chicago, Illinois, United States
NorthShore University HealthSystem /ID# 158265
🇺🇸Evanston, Illinois, United States
Southwest Gastroenterology /ID# 164781
🇺🇸Oak Lawn, Illinois, United States
Cotton O'Neil Clinical Research Center, Digestive Health /ID# 154722
🇺🇸Topeka, Kansas, United States
Duplicate_University of Kentucky Chandler Medical Center /ID# 157120
🇺🇸Lexington, Kentucky, United States
University of Louisville Hospital /ID# 210525
🇺🇸Louisville, Kentucky, United States
GI Alliance /ID# 161963
🇺🇸Baton Rouge, Louisiana, United States
Houma Digestive Health Special /ID# 158264
🇺🇸Houma, Louisiana, United States
Delricht Research /ID# 206644
🇺🇸New Orleans, Louisiana, United States
Nola Research Works, LLC /ID# 161317
🇺🇸New Orleans, Louisiana, United States
Louisiana Research Center, LLC /ID# 162237
🇺🇸Shreveport, Louisiana, United States
Metropolitan Gastroenterology Group - Chevy Chase /ID# 154832
🇺🇸Chevy Chase, Maryland, United States
Gastro Center of Maryland /ID# 165001
🇺🇸Columbia, Maryland, United States
University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 157126
🇺🇸Ann Arbor, Michigan, United States
Clin Res Inst of Michigan, LLC /ID# 169179
🇺🇸Chesterfield, Michigan, United States
Center for Digestive Health /ID# 154683
🇺🇸Troy, Michigan, United States
Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinic /ID# 161313
🇺🇸Wyoming, Michigan, United States
Mayo Clinic - Rochester /ID# 163086
🇺🇸Rochester, Minnesota, United States
St. Louis University /ID# 161883
🇺🇸Saint Louis, Missouri, United States
University of Nebraska Medical Center /ID# 210058
🇺🇸Omaha, Nebraska, United States
Vector Clinical Trials /ID# 160170
🇺🇸Las Vegas, Nevada, United States
Revival Research Institute, Inc /ID# 210985
🇺🇸Las Vegas, Nevada, United States
NY Scientific /ID# 158294
🇺🇸Brooklyn, New York, United States
Saratoga Schenectady Gastroenterology Associates - Burnt Hills /ID# 213447
🇺🇸Burnt Hills, New York, United States
Intercity Advanced Gastroentertology Center /ID# 215205
🇺🇸Fresh Meadows, New York, United States
Duplicate_Northwell Health Division of Gastroenterology at Great Neck /ID# 168738
🇺🇸Great Neck, New York, United States
NYU Langone Long Island Clinical Research Associates /ID# 154829
🇺🇸Lake Success, New York, United States
Digestive Disease Care /ID# 211777
🇺🇸New Hyde Park, New York, United States
NYU Langone Medical Center /ID# 160169
🇺🇸New York, New York, United States
Weill Cornell Medicine /ID# 165878
🇺🇸New York, New York, United States
Icahn School of Medicine at Mount Sinai /ID# 165612
🇺🇸New York, New York, United States
Columbia Univ Medical Center /ID# 161899
🇺🇸New York, New York, United States
Lenox Hill Hospital /ID# 168467
🇺🇸New York, New York, United States
Duplicate_DiGiovanna Institute for Medical Education & Research /ID# 171126
🇺🇸North Massapequa, New York, United States
Univ NC Chapel Hill /ID# 154833
🇺🇸Chapel Hill, North Carolina, United States
Atrium Health Carolinas Medical Center /ID# 158428
🇺🇸Charlotte, North Carolina, United States
Wake Radiology UNC REX Healthcare - Raleigh Office /ID# 154873
🇺🇸Raleigh, North Carolina, United States
Plains Clinical Research Center, LLC /ID# 169718
🇺🇸Fargo, North Dakota, United States
Tri-State Endoscopy Center /ID# 154927
🇺🇸Cincinnati, Ohio, United States
Cleveland Clinic Main Campus /ID# 209226
🇺🇸Cleveland, Ohio, United States
The Ohio State University /ID# 164708
🇺🇸Columbus, Ohio, United States
Optimed Research, Ltd. /ID# 167887
🇺🇸Columbus, Ohio, United States
Hometown Urgent Care and Resea /ID# 170464
🇺🇸Dayton, Ohio, United States
Great Lakes Gastroenterology Research, LLC /ID# 201770
🇺🇸Mentor, Ohio, United States
Hightower Clinical /ID# 211993
🇺🇸Oklahoma City, Oklahoma, United States
Digestive Disease Specialists /ID# 170775
🇺🇸Oklahoma City, Oklahoma, United States
Adult Gastroenterology Associates - Gen 1 Research /ID# 208864
🇺🇸Tulsa, Oklahoma, United States
Children's Hospital of Pittsburgh of UPMC /ID# 212544
🇺🇸Pittsburgh, Pennsylvania, United States
Digestive Disease Associates, LTD /ID# 208297
🇺🇸Wyomissing, Pennsylvania, United States
Medical University of South Carolina /ID# 212858
🇺🇸Charleston, South Carolina, United States
Gastroenterology Associates, P.A. of Greenville /ID# 154904
🇺🇸Greenville, South Carolina, United States
Rapid City Medical Center - GI Research /ID# 163838
🇺🇸Rapid City, South Dakota, United States
Gastro One /ID# 154726
🇺🇸Cordova, Tennessee, United States
East Tennessee Research Institute /ID# 168739
🇺🇸Johnson City, Tennessee, United States
Clinical Neuroscience Solutions - Memphis /ID# 164180
🇺🇸Memphis, Tennessee, United States
Vanderbilt University Medical Center /ID# 157121
🇺🇸Nashville, Tennessee, United States
TX Clinical Research Institute /ID# 159404
🇺🇸Arlington, Texas, United States
Inquest Clinical Research /ID# 165694
🇺🇸Baytown, Texas, United States
Texas Digestive Disease Consultants /ID# 209946
🇺🇸Cedar Park, Texas, United States
GI Alliance /ID# 209797
🇺🇸Cedar Park, Texas, United States
Baylor Scott & White Center for Inflammatory Bowel Diseases /ID# 159406
🇺🇸Dallas, Texas, United States
Duplicate_DHAT Research Institute /ID# 158208
🇺🇸Garland, Texas, United States
Vilo Research Group Inc /ID# 207655
🇺🇸Houston, Texas, United States
Baylor College of Medicine /ID# 158203
🇺🇸Houston, Texas, United States
Centex Studies, Inc. - Houston /ID# 201219
🇺🇸Houston, Texas, United States
Clinical Associates in Research Therapeutics of America, LLC /ID# 161323
🇺🇸San Antonio, Texas, United States
Southern Star Research Institute, LLC /ID# 168773
🇺🇸San Antonio, Texas, United States
Baylor Scott & White Center for Diagnostic Medicine /ID# 204131
🇺🇸Temple, Texas, United States
Tyler Research Institute, LLC /ID# 166797
🇺🇸Tyler, Texas, United States
Gastro Health & Nutrition - Victoria /ID# 164290
🇺🇸Victoria, Texas, United States
Advanced Research Institute /ID# 154907
🇺🇸Ogden, Utah, United States
Velocity Clinical Research - Salt Lake City /ID# 161778
🇺🇸West Jordan, Utah, United States
Richmond VA Medical Center /ID# 159988
🇺🇸Richmond, Virginia, United States
Duplicate_Virginia Mason Medical Center /ID# 155556
🇺🇸Seattle, Washington, United States
West Virginia University Hospitals /ID# 167941
🇺🇸Morgantown, West Virginia, United States
Hospital Britanico de Buenos Aires /ID# 168077
🇦🇷Ciudad Autonoma de Buenos Aire, Ciudad Autonoma De Buenos Aires, Argentina
Cemic /Id# 168078
🇦🇷Ciudad Autonoma de Buenos Aire, Ciudad Autonoma De Buenos Aires, Argentina
Hospital Provincial del Centenario /ID# 170886
🇦🇷Rosario, Santa Fe, Argentina
Hospital Privado Universitario - Hospital Privado Centro Medico de Cordoba S.A. /ID# 168076
🇦🇷Cordoba, Argentina
Mater Misericordiae Limited /ID# 167220
🇦🇺South Brisbane, Queensland, Australia
Griffith University /ID# 212635
🇦🇺Southport, Queensland, Australia
Lyell McEwin Hospital /ID# 212215
🇦🇺Elizabeth Vale, South Australia, Australia
Emeritus Research /ID# 213512
🇦🇺Camberwell, Victoria, Australia
Universitaetsklinikum St. Poelten /ID# 166424
🇦🇹Sankt Poelten, Niederoesterreich, Austria
Medizinische Universitaet Graz /ID# 158140
🇦🇹Graz, Steiermark, Austria
Krankenhaus der Barmherzigen Brueder Wien /ID# 212060
🇦🇹Vienna, Wien, Austria
Medizinische Universitaet Wien /ID# 158141
🇦🇹Vienna, Wien, Austria
Grodno city clinical hospital #2 /ID# 205113
🇧🇾Grodno, Grodnenskaya Oblast, Belarus
Gomel Regional Clinical Hospital /ID# 205112
🇧🇾Gomel, Belarus
Vitebsk Regional Advanced Clin /ID# 206778
🇧🇾Витебск, Belarus
Imelda Ziekenhuis /ID# 157403
🇧🇪Bonheiden, Antwerpen, Belgium
AZ Sint-Maarten /ID# 212876
🇧🇪Mechelen, Antwerpen, Belgium
ZAS Palfijn /ID# 212877
🇧🇪Merksem, Antwerpen, Belgium
Universite Libre de Bruxelles - Hopital Erasme /ID# 157408
🇧🇪Anderlecht, Bruxelles-Capitale, Belgium
Cliniques Universitaires UCL Saint-Luc /ID# 157406
🇧🇪Woluwe-Saint-Lambert, Bruxelles-Capitale, Belgium
Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant /ID# 157412
🇧🇪Yvoir, Namur, Belgium
UZ Gent /ID# 157405
🇧🇪Gent, Oost-Vlaanderen, Belgium
Universitair Ziekenhuis Leuven /ID# 157407
🇧🇪Leuven, Vlaams-Brabant, Belgium
AZ-Delta /ID# 157402
🇧🇪Roeselare, West-Vlaanderen, Belgium
AZ Maria Middelares /ID# 213532
🇧🇪Gent, Belgium
Percuro Clinical Research, Ltd /ID# 161631
🇨🇦Victoria, British Columbia, Canada
AZ Groeninge /ID# 211513
🇧🇪Kortrijk, Belgium
CHU de Liege /ID# 157409
🇧🇪Liege, Belgium
Groupe Sante CHC - Clinique du MontLegia /ID# 157404
🇧🇪Liege, Belgium
Klinicki centar Banja Luka /ID# 164513
🇧🇦Banja Luka, Republika Srpska, Bosnia and Herzegovina
Clinical Center University of Sarajevo /ID# 165139
🇧🇦Sarajevo, Bosnia and Herzegovina
UMHAT Dr Georgi Stranski EAD /ID# 203976
🇧🇬Pleven, Bulgaria
Umbal Kaspela /ID# 165700
🇧🇬Plovdiv, Bulgaria
2nd Mhat /ID# 165702
🇧🇬Sofia, Bulgaria
Tokuda Hospital Sofia /ID# 165701
🇧🇬Sofia, Bulgaria
UMHAT Sveti Ivan Rilski /ID# 204815
🇧🇬Sofia, Bulgaria
Duplicate_UMHAT Tsaritsa Joanna - ISUL /ID# 211242
🇧🇬Sofia, Bulgaria
MHAT Trakia /ID# 201668
🇧🇬Stara Zagora, Bulgaria
University of Calgary /ID# 157155
🇨🇦Calgary, Alberta, Canada
Allen Whey Khye Lim Professional Corporation /ID# 169763
🇨🇦Edmonton, Alberta, Canada
University of Alberta Hospital /ID# 157099
🇨🇦Edmonton, Alberta, Canada
Covenant Health /ID# 161632
🇨🇦Edmonton, Alberta, Canada
Fraser Clinical Trials Inc /ID# 159055
🇨🇦New Westminster, British Columbia, Canada
(G.I.R.I.) GI Research Institute Foundation /ID# 157096
🇨🇦Vancouver, British Columbia, Canada
Medical Center of LLC Medbud-Clinic /ID# 216998
🇺🇦Kyiv, Ukraine
QEII - Health Sciences Centre /ID# 157088
🇨🇦Halifax, Nova Scotia, Canada
IWK Health Center /ID# 165905
🇨🇦Halifax, Nova Scotia, Canada
Hamilton Health Sciences - McMaster University Medical Centre /ID# 157184
🇨🇦Hamilton, Ontario, Canada
London Health Sciences Center- University Hospital /ID# 157161
🇨🇦London, Ontario, Canada
Scott Shulman Medicine Professional Corporation /ID# 165906
🇨🇦North Bay, Ontario, Canada
Medicor Research Inc /ID# 157150
🇨🇦Sudbury, Ontario, Canada
Mount Sinai Hospital /ID# 169764
🇨🇦Toronto, Ontario, Canada
Toronto Digestive Disease Associates /ID# 157158
🇨🇦Vaughan, Ontario, Canada
Hotel Dieu de Levis /ID# 214377
🇨🇦Lévis, Quebec, Canada
CIUSSS de l'est de l'Ile-de-Montreal - Hopital Maisonneuve-Rosemont /ID# 159056
🇨🇦Montreal, Quebec, Canada
Montreal General Hospital- McGill University Health Center /ID# 157085
🇨🇦Montreal, Quebec, Canada
CISSS de la Monteregie Centre - Hopital Charles Le Moyne /ID# 161630
🇨🇦Greenfield Park, Canada
Hospital Guillermo Grant Benavente de Concepción /ID# 210760
🇨🇱Concepción, Bio-Bio, Chile
Hospital Las Higueras /ID# 167092
🇨🇱Talcahuano, Bio-Bio, Chile
Complejo Asistencial Dr. Sotero del Rio /ID# 169384
🇨🇱Santiago, Region Metropolitana De Santiago, Chile
Servicio de Salud Occidente Hospital San Juan de Dios /ID# 171122
🇨🇱Santiago, Region Metropolitana Santiago, Chile
The Sixth Affiliated Hospital of Sun Yat-sen University /ID# 210784
🇨🇳Guangzhou, Guangdong, China
The Second Hospital of Hebei Medical University /ID# 212738
🇨🇳Shijiazhuang, Hebei, China
Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 211039
🇨🇳Wuhan, Hubei, China
Tongji Hospital Tongji Medical College of HUST /ID# 210858
🇨🇳Wuhan, Hubei, China
Renmin Hospital of Wuhan University /ID# 214874
🇨🇳Wuhan, Hubei, China
The Second Xiangya Hospital of Central South University /ID# 211700
🇨🇳Changsha, Hunan, China
The First Affiliated Hospital of Nanchang University /ID# 211036
🇨🇳Nanchang, Jiangxi, China
Ruijin Hospital, Shanghai Jiaotong University School of Medicine /ID# 210840
🇨🇳Shanghai, Shanghai, China
Renji Hospital, Shanghai Jiaotong University School of Medicine /ID# 210705
🇨🇳Shanghai, Shanghai, China
Shanghai East Hospital /ID# 212684
🇨🇳Shanghai, Shanghai, China
West China Hospital, Sichuan University /ID# 210890
🇨🇳Chengdu, Sichuan, China
Tianjin Medical University General Hospital /ID# 210926
🇨🇳Tianjin, Tianjin, China
The second affiliated hospital of Zhejiang University school of medicine /ID# 210724
🇨🇳Hangzhou, Zhejiang, China
Sir Run Run Shaw Hospital Zhejiang University School of Medicine /ID# 210625
🇨🇳Hangzhou, Zhejiang, China
Jinhua Municipal Central Hospital /ID# 215628
🇨🇳Jinhua, Zhejiang, China
Instituto de Coloproctologia /ID# 158743
🇨🇴Medellin, Antioquia, Colombia
Hospital Universitario San Vic /ID# 171486
🇨🇴Medellin, Antioquia, Colombia
Hospital Pablo Tobón Uribe /ID# 158730
🇨🇴Medellín, Antioquia, Colombia
Hospital Univ San Ignacio /ID# 158734
🇨🇴Bogota, Cundinamarca, Colombia
Klinicka bolnica Dubrava Zagreb /ID# 157560
🇭🇷Zagreb, Grad Zagreb, Croatia
Klinicki bolnicki centar Sestre milosrdnice /ID# 157728
🇭🇷Zagreb, Grad Zagreb, Croatia
Klinicki bolnicki centar Zagreb /ID# 157561
🇭🇷Zagreb, Grad Zagreb, Croatia
Poliklinika Borzan d.o.o. /ID# 157559
🇭🇷Osijek, Osjecko-baranjska Zupanija, Croatia
Klinicki Bolnicki Centar (KBC) Split /ID# 157562
🇭🇷Split, Splitsko-dalmatinska Zupanija, Croatia
Zadar General Hospital /ID# 157563
🇭🇷Zadar, Croatia
Duplicate_Institut klinicke a experimentalni mediciny (IKEM) /ID# 165465
🇨🇿Prague 4, Praha 4, Czechia
Iscare Klinické Centrum /ID# 225794
🇨🇿Prague, Praha 9, Czechia
Hepato-Gastroenterologie HK, s.r.o. /ID# 163225
🇨🇿Hradec Kralove, Czechia
Nemocnice Pardubickeho kraje, a.s. /ID# 163226
🇨🇿Pardubice, Czechia
Kyiv Railway Clinical Hosp No.2 /ID# 217366
🇺🇦Kyiv, Ukraine
Nemocnice Milosrdnych sester sv. Karla Boromejskeho v Praze /ID# 211306
🇨🇿Praha, Czechia
Duplicate_Internal Medicine Department, Faculty of Medicine, AinShams University /ID# 157506
🇪🇬Cairo, Egypt
North Estonia Medical Centre /ID# 164326
🇪🇪Mustamäe Linnaosa, Harjumaa, Estonia
East Tallinn Central Hospital /ID# 157074
🇪🇪Tallinn, Harjumaa, Estonia
Axon Clinical, s.r.o. /ID# 163223
🇨🇿Praha, Czechia
Fakultni Thomayerova nemocnice /ID# 162941
🇨🇿Praha, Czechia
ResTrial s.r.o. /ID# 211078
🇨🇿Praha, Czechia
Nemocnice Horovice - NH Hospital a.s /ID# 211077
🇨🇿Praha, Czechia
Kobenhavns Universitet - Hvidovre Hospital (HH) /ID# 155530
🇩🇰Hvidovre, Hovedstaden, Denmark
Aarhus Universitetshospital - Skejby /ID# 155664
🇩🇰Aarhus, Midtjylland, Denmark
Roskilde Sygehus /ID# 155532
🇩🇰Roskilde, Sjælland, Denmark
Sygehusenheden Nyborg - OUH /ID# 161525
🇩🇰Nyborg, Syddanmark, Denmark
Odense University Hospital /ID# 155531
🇩🇰Odense, Syddanmark, Denmark
Alexandria University /ID# 157187
🇪🇬Alexandria, Al Iskandariyah, Egypt
Alexandria University /ID# 164540
🇪🇬Alexandria, Al Iskandariyah, Egypt
Zagazig University Hospitals /ID# 164539
🇪🇬Al Sharqia, Egypt
Clinical Research Center, Faculty of Medicine, Cairo university /ID# 157175
🇪🇬Cairo, Egypt
National Hepatology and Tropical Medicine Research Institute /ID# 157874
🇪🇬Cairo, Egypt
West Tallinn Central Hospital /ID# 157075
🇪🇪Tallinn, Harjumaa, Estonia
Chu de Nice-Hopital Larchet Ii /Id# 162557
🇫🇷Nice, Alpes-Maritimes, France
Centre Hospitalier Universitaire de Bordeaux /ID# 162558
🇫🇷Pessac CEDEX, Gironde, France
CHU Montpellier - Hopital Saint Eloi /ID# 215147
🇫🇷Montpellier Cedex 5, Herault, France
Hopital Beaujon /ID# 166284
🇫🇷Clichy, Ile-de-France, France
Centre Medico Chirurgical Ambroise Pare Hartmann /ID# 249858
🇫🇷Neuilly Sur Seine, Ile-de-France, France
Duplicate_CHU Grenoble - Hopital Michallon /ID# 212834
🇫🇷La Tronche, Isere, France
Centre Hospitalier Universitaire de Saint Étienne - Hôpital Nord /ID# 162562
🇫🇷St-Priest-en-Jarez, Loire, France
CHRU Nancy - Hopitaux de Brabois /ID# 162561
🇫🇷Vandoeuvre-les-Nancy, Meurthe-et-Moselle, France
CHRU Lille - Hopital Claude Huriez /ID# 162559
🇫🇷Lille, Nord, France
HCL - Hopital Lyon Sud /ID# 162560
🇫🇷Pierre Benite CEDEX, Rhone, France
CHU Amiens-Picardie Site Sud /ID# 165058
🇫🇷Amiens CEDEX 1, Somme, France
CHRU Pontchaillou /ID# 213209
🇫🇷Rennes, France
Universitaetsklinikum Freiburg /ID# 162030
🇩🇪Freiburg, Baden-Wuerttemberg, Germany
Praxis fuer Gastroenterologie /ID# 166150
🇩🇪Heidelberg, Baden-Wuerttemberg, Germany
Universitatsklinikum Mannheim /ID# 162031
🇩🇪Mannheim, Baden-Wuerttemberg, Germany
Universitaetsklinikum Ulm /ID# 164990
🇩🇪Ulm, Baden-Wuerttemberg, Germany
Medizinisches Versorgunszentrum Dachau /ID# 211555
🇩🇪Dachau, Bayern, Germany
Universitaetsklinikum Erlangen /ID# 159343
🇩🇪Erlangen, Bayern, Germany
Duplicate_Agaplesion Markus Krankenhaus /ID# 159345
🇩🇪Frankfurt am Main, Hessen, Germany
Universitaetsklinikum Frankfurt /ID# 212979
🇩🇪Frankfurt am Main, Hessen, Germany
Klinikum Lueneburg /ID# 163678
🇩🇪Lueneburg, Niedersachsen, Germany
Evangelisches Krankenhaus Kalk /ID# 212726
🇩🇪Cologne, Nordrhein-Westfalen, Germany
Praxiszentrum fuer Gastroenterologie /ID# 211966
🇩🇪Grevenbroich, Nordrhein-Westfalen, Germany
Universitaetsklinikum Koeln /ID# 164989
🇩🇪Köln, Nordrhein-Westfalen, Germany
Gastroenterologische Gemeinschaftspraxis Minden /ID# 162029
🇩🇪Minden, Nordrhein-Westfalen, Germany
Universitaetsklinikum Muenster /ID# 159344
🇩🇪Muenster, Nordrhein-Westfalen, Germany
Zentrum für Gastroenterologie Saar MVZ GmbH /ID# 210528
🇩🇪Saarbrücken, Saarland, Germany
Eugastro /ID# 212078
🇩🇪Leipzig, Sachsen, Germany
Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 159349
🇩🇪Kiel, Schleswig-Holstein, Germany
Universitaetsklinikum Jena /ID# 159351
🇩🇪Jena, Thueringen, Germany
Krankenhaus Waldfriede /ID# 212727
🇩🇪Berlin-Zehlendorf, Germany
Duplicate_Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 212220
🇩🇪Berlin, Germany
Duplicate_Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 212894
🇩🇪Berlin, Germany
Gastroenterologische Spezialpraxis am Wittenbergplatz /ID# 211974
🇩🇪Berlin, Germany
MVZ fuer Gastroenterlogie am Bayerischen Platz /ID# 159350
🇩🇪Berlin, Germany
DRK Kliniken Berlin Westend /ID# 166151
🇩🇪Berlin, Germany
Stadtisches Klinikum Braunschweig /ID# 163680
🇩🇪Braunschweig, Germany
Medizinische Hochschule Hannover /ID# 162032
🇩🇪Hannover, Germany
Universitaetsklinikum Magdeburg /ID# 211843
🇩🇪Magdeburg, Germany
Universitaetsklinikum Regensburg /ID# 163813
🇩🇪Regensburg, Germany
General Hospital of Chest Diseases of Athens SOTIRIA /ID# 170914
🇬🇷Athens, Attiki, Greece
General Hospital of Nikaia-Piraeus "Agios Panteleimon" /ID# 157424
🇬🇷Nikaia, Attiki, Greece
Tzaneio general hospital of Piraeus /ID# 206443
🇬🇷Piraeus, Attiki, Greece
University General Hospital of Heraklion PA.G.N.I /ID# 157422
🇬🇷Heraklion, Kriti, Greece
General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 157423
🇬🇷Athens, Greece
University General Hospital of Ioannina /ID# 157420
🇬🇷Ioannina, Greece
Theageneio Anticancer Hospital /ID# 163897
🇬🇷Thessaloniki, Greece
Queen Mary Hospital /ID# 163923
🇭🇰Hong Kong, Hong Kong
Tuen Mun Hospital /ID# 163905
🇭🇰Hong Kong, Hong Kong
Duplicate_Beaumont Hospital /ID# 157543
🇮🇪Beaumont, Dublin, Ireland
St Vincent's University Hospital /ID# 157540
🇮🇪Elm Park, Dublin, Ireland
University Hospital Galway /ID# 157541
🇮🇪Galway, Ireland
The Edith Wolfson Medical Center /ID# 217331
🇮🇱Ashkelon, HaDarom, Israel
Soroka University Medical Center /ID# 157794
🇮🇱Be'er Sheva, HaDarom, Israel
The Chaim Sheba Medical Center /ID# 157793
🇮🇱Ramat Gan, Tel-Aviv, Israel
The Chaim Sheba Medical Center /ID# 171069
🇮🇱Ramat Gan, Tel-Aviv, Israel
Tel Aviv Sourasky Medical Center /ID# 157792
🇮🇱Tel Aviv, Tel-Aviv, Israel
Shaare Zedek Medical Center /ID# 163541
🇮🇱Jerusalem, Yerushalayim, Israel
Shaare Zedek Medical Center /ID# 171068
🇮🇱Jerusalem, Yerushalayim, Israel
Hadassah Medical Center-Hebrew University /ID# 165914
🇮🇱Jerusalem, Yerushalayim, Israel
Duplicate_Rambam Medical Center /ID# 171067
🇮🇱Haifa, Israel
Duplicate_AOU Ospendali Riuniti di Ancona /ID# 162436
🇮🇹Torrette, Ancona, Italy
IRCCS AOU di Bologna - Policlinico Sant'Orsola-Malpighi /ID# 155643
🇮🇹Bologna, Emilia-Romagna, Italy
Duplicate_Ospedale Policlinico San Martino /ID# 162439
🇮🇹Genoa, Genova, Italy
IRCCS Istituto Clinico Humanitas /ID# 155642
🇮🇹Rozzano, Lombardia, Italy
ASST Fatebenefratelli Sacco /ID# 155639
🇮🇹Milan, Milano, Italy
ASST Rhodense/Presidio Ospedaliero di Rho /ID# 212227
🇮🇹Rho, Milano, Italy
Duplicate_Fondazione Policlinico Universitario Campus Bio-Medico di Roma /ID# 162438
🇮🇹Rome, Roma, Italy
Azienda Ospedaliera Universitaria Policlinico Tor Vergata /ID# 158022
🇮🇹Rome, Roma, Italy
Azienda Ospedaliera San Camillo Forlanini /ID# 155644
🇮🇹Rome, Roma, Italy
Duplicate_Azienda Ospedaliero-Universitaria Policlinico Umberto I /ID# 166912
🇮🇹Rome, Roma, Italy
Presidio Columbus-Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Un /ID# 155640
🇮🇹Rome, Roma, Italy
Duplicate_Azienda Ospedaliera Univ. Meyer /ID# 167992
🇮🇹Florence, Toscana, Italy
IRCCS Ospedale Sacro Cuore Don Calabria /ID# 161299
🇮🇹Negrar, Verona, Italy
Ospedale Cannizzaro /ID# 161300
🇮🇹Catania, Italy
Azienda Ospedaliero-Universitaria Renato Dulbecco /ID# 212016
🇮🇹Catanzaro, Italy
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico /ID# 155641
🇮🇹Milano, Italy
Duplicate_Azienda Ospedaliero-Universitaria Policlinico di Modena /ID# 212028
🇮🇹Modena, Italy
Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello /ID# 155645
🇮🇹Palermo, Italy
Duplicate_Fondazione IRCCS Policlinico S. Matteo /ID# 212031
🇮🇹Pavia, Italy
Aichi Medical University Hospital /ID# 160097
🇯🇵Nagakute, Aichi, Japan
Nagoya City University Hospital /ID# 160100
🇯🇵Nagoya shi, Aichi, Japan
Daido Clinic - Nagoya /ID# 211476
🇯🇵Nagoya-shi, Aichi, Japan
Nagoya University Hospital /ID# 160116
🇯🇵Nagoya-shi, Aichi, Japan
Duplicate_Fujita Health University Hospital /ID# 163234
🇯🇵Toyoake-shi, Aichi, Japan
Tokatsu Tsujinaka Hospital /ID# 163352
🇯🇵Abiko-shi, Chiba, Japan
Duplicate_Chiba University Hospital /ID# 217533
🇯🇵Chiba-shi, Chiba, Japan
Tsujinaka Hospital Kashiwanoha /ID# 213848
🇯🇵Kashiwa-shi, Chiba, Japan
The Jikei University Kashiwa Hospital /ID# 200030
🇯🇵Kashiwa-shi, Chiba, Japan
Toho University Sakura Medical Center /ID# 160099
🇯🇵Sakura-shi, Chiba, Japan
Fukuoka University Hospital /ID# 217793
🇯🇵Fukuoka-shi, Fukuoka, Japan
Kurume University Hospital /ID# 160106
🇯🇵Kurume-shi, Fukuoka, Japan
NHO Fukuyama Medical Center /ID# 163577
🇯🇵Fukuyama-shi, Hiroshima, Japan
Hiroshima University Hospital /ID# 160109
🇯🇵Hiroshima-shi, Hiroshima, Japan
Asahikawa Medical University Hospital /ID# 162848
🇯🇵Asahikawa-shi, Hokkaido, Japan
Sapporo Tokushukai Hospital /ID# 213492
🇯🇵Sapporo-shi, Hokkaido, Japan
Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital /ID# 160096
🇯🇵Sapporo-shi, Hokkaido, Japan
Sapporo Medical University Hospital /ID# 163056
🇯🇵Sapporo-shi, Hokkaido, Japan
Nishinomiya Municipal Central Hospital /ID# 210103
🇯🇵Nishinomiya-shi, Hyogo, Japan
Hyogo Medical University Hospital /ID# 160107
🇯🇵Nishinomiya-shi, Hyogo, Japan
NHO Mito Medical Center /ID# 160092
🇯🇵Higashiibaraki-gun, Ibaraki, Japan
Kanazawa University Hospital /ID# 202258
🇯🇵Kanazawa-shi, Ishikawa, Japan
Gokeikai Ofuna Chuo Hospital /ID# 171066
🇯🇵Kamakura-shi, Kanagawa, Japan
Kitasato University Hospital /ID# 171065
🇯🇵Sagamihara-shi, Kanagawa, Japan
Yokohama City University Medical Center /ID# 163907
🇯🇵Yokohama shi, Kanagawa, Japan
Duplicate_Yokohama Municipal Citizen's Hospital /ID# 207161
🇯🇵Yokohama-shi, Kanagawa, Japan
Mie University Hospital /ID# 203640
🇯🇵Tsu-shi, Mie, Japan
Yokkaichi Hazu Medical Center /ID# 163764
🇯🇵Yokkaichi-shi, Mie, Japan
Tohoku University Hospital /ID# 162847
🇯🇵Sendai-shi, Miyagi, Japan
Tohoku Rosai Hospital /ID# 163229
🇯🇵Sendai-shi, Miyagi, Japan
Osaka Metropolitan University Hospital /ID# 160117
🇯🇵Osaka-shi, Osaka, Japan
Saitama Medical Center /ID# 160093
🇯🇵Kawagoe-shi, Saitama, Japan
Tokitokai Tokito clinic /ID# 160110
🇯🇵Saitama-shi, Saitama, Japan
Shiga University of Medical Science Hospital /ID# 164025
🇯🇵Otsu, Shiga, Japan
Hamamatsu University Hospital /ID# 205690
🇯🇵Hamamatsu-shi, Shizuoka, Japan
NHO Shizuoka Medical Center /ID# 163057
🇯🇵Sunto-gun, Shizuoka, Japan
Institute of Science Tokyo Hospital /ID# 160095
🇯🇵Bunkyo-ku, Tokyo, Japan
Tokai University Hachioji Hospital /ID# 160098
🇯🇵Hachioji-shi, Tokyo, Japan
The Jikei University Hospital /ID# 163209
🇯🇵Minato-ku, Tokyo, Japan
Kitasato University Kitasato Institute Hospital /ID# 160105
🇯🇵Minato-ku, Tokyo, Japan
Tokyo Women's Medical University Hospital /ID# 205974
🇯🇵Shinjuku-ku, Tokyo, Japan
Wakayama Medical University Hospital /ID# 202561
🇯🇵Wakayama-shi, Wakayama, Japan
Yamagata University Hospital /ID# 200159
🇯🇵Yamagata-shi, Yamagata, Japan
Yamanashi Prefectural Central Hospital /ID# 160094
🇯🇵Kofu-shi, Yamanashi, Japan
Kyorin University - Mitaka Campus /ID# 160114
🇯🇵Mitaka, Japan
Inje University Haeundae Hospital /ID# 202518
🇰🇷Busan, Busan Gwang Yeogsi, Korea, Republic of
Pusan National University Hospital /ID# 158695
🇰🇷Busan, Busan Gwang Yeogsi, Korea, Republic of
The Catholic University of Korea, Daejeon St. Mary's Hospital /ID# 213554
🇰🇷Daejeon, Daejeon Gwang Yeogsi, Korea, Republic of
Hanyang University Guri Hospital /ID# 158690
🇰🇷Guri-si, Gyeonggido, Korea, Republic of
Duplicate_CHA University Bundang Medical Center /ID# 158698
🇰🇷Seongnam si, Gyeonggido, Korea, Republic of
The Catholic University Of Korea St. Vincent's Hospital /ID# 158693
🇰🇷Suwon, Gyeonggido, Korea, Republic of
Dong-A University Medical Center /ID# 158699
🇰🇷Busan, Gyeongsangnamdo, Korea, Republic of
Kangbuk Samsung Hospital /ID# 158694
🇰🇷Seoul, Seoul Teugbyeolsi, Korea, Republic of
Asan Medical Center /ID# 158696
🇰🇷Seoul, Seoul Teugbyeolsi, Korea, Republic of
Samsung Medical Center /ID# 158692
🇰🇷Seoul, Seoul Teugbyeolsi, Korea, Republic of
Yeungnam University Medical Center /ID# 158691
🇰🇷Daegu, Korea, Republic of
Yonsei University Health System Severance Hospital /ID# 158689
🇰🇷Seoul, Korea, Republic of
VCA Polyclinic Aura /ID# 159611
🇱🇻Riga, Latvia
Pauls Stradins Clinical University Hospital /ID# 159612
🇱🇻Riga, Latvia
Duplicate_Digestive Disease Center Gastro /ID# 163107
🇱🇻Riga, Latvia
Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 162583
🇱🇹Kaunas, Lithuania
Vilnius University Hospital Santaros Klinikos /ID# 162514
🇱🇹Vilnius, Lithuania
Queen Elizabeth Hospital /ID# 160664
🇲🇾Division Pantai Barat Utara, Sabah, Malaysia
Universiti Kebangsaan Malaysia (UKM) Medical Centre /ID# 201363
🇲🇾Kuala Lumpur, Selangor, Malaysia
Universiti Sains Malaysia /ID# 160666
🇲🇾Kelantan, Malaysia
Investigacion Biomedica para el Desarrollo de Farmacos, S.A. de C.V. /ID# 170734
🇲🇽Zapopan, Jalisco, Mexico
JM Research SC /ID# 170729
🇲🇽Cuernavaca, Morelos, Mexico
Unidad de Atencion Medica e Investigacion en Salud /ID# 170732
🇲🇽Merida, Yucatan, Mexico
Health Pharma Professional Research S.A de C.V /ID# 170730
🇲🇽Del. Benito Juárez, Mexico
Elisabeth Tweesteden Ziekenhuis /ID# 163632
🇳🇱Tilburg, Noord-Brabant, Netherlands
Amsterdam UMC, locatie AMC /ID# 157956
🇳🇱Amsterdam, Noord-Holland, Netherlands
Aotearoa Clinical Trials /ID# 167226
🇳🇿Papatoetoe, Auckland, New Zealand
Christchurch Hospital /ID# 167224
🇳🇿Christchurch, Canterbury, New Zealand
Dunedin Hospital /ID# 167227
🇳🇿Otago, New Zealand
Duplicate_Wellington Hospital (Capital and Coast District Health Board) /ID# 167225
🇳🇿Wellington, New Zealand
Duplicate_Vestre viken - Baerum Sykehus /ID# 212996
🇳🇴Gjettum, Akershus, Norway
Helse More og Romsdal HF, Alesund sjukehus /ID# 212810
🇳🇴Ålesund, More Og Romsdal, Norway
Sykehuset Levanger Helse NT /ID# 201669
🇳🇴Levanger, Nord-Trondelag, Norway
Planetmed Sp. z o.o. /ID# 202799
🇵🇱Wroclaw, Dolnoslaskie, Poland
Gastromed Sp. z o.o /ID# 212476
🇵🇱Torun, Kujawsko-pomorskie, Poland
Uniwersytecki Szpital Kliniczny nr 1 im. Norberta Barlickiego w Lodzi /ID# 212477
🇵🇱Lodz, Lodzkie, Poland
1 Wojskowy Szpital Kliniczny Z Poliklinika /Id# 210940
🇵🇱Lublin, Lubelskie, Poland
Uniwersytecki Szpital Kliniczny Nr 4 W Lublinie /Id# 210941
🇵🇱Lublin, Lubelskie, Poland
Centrum Zdrowia MDM /ID# 163570
🇵🇱Warszawa, Mazowieckie, Poland
Instytut Pomnik - Centrum Zdrowia Dziecka /ID# 213580
🇵🇱Warszawa, Mazowieckie, Poland
Centrum Medyczne LukaMed Joanna Luka /ID# 212478
🇵🇱Chojnice, Pomorskie, Poland
H-T Centrum Medyczne Endoterapia /ID# 212475
🇵🇱Tychy, Slaskie, Poland
Wojewodzki Szpital Specjalistyczny /ID# 212474
🇵🇱Olsztyn, Warminsko-mazurskie, Poland
Solumed Centrum Medyczne /ID# 163569
🇵🇱Poznan, Wielkopolskie, Poland
Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wroclaw /ID# 212601
🇵🇱Wroclaw, Poland
Panstwowy Instytut Medyczny MSWiA w Warszawie /ID# 163582
🇵🇱Warszawa, Mazowieckie, Poland
NZOZ Vivamed Jadwiga Miecz /ID# 202800
🇵🇱Warszawa, Mazowieckie, Poland
Centrum Medyczne Medyk /ID# 212891
🇵🇱Rzeszow, Podkarpackie, Poland
Duplicate_Hospital da Senhora da Oliveira Guimaraes, EPE /ID# 160737
🇵🇹Guimaraes, Braga, Portugal
Centro Hospitalar Universitário do Algarve, EPE - Hospital de Portimão /ID# 167752
🇵🇹Portimão, Faro, Portugal
Centro Hospitalar de Entre Douro e Vouga /ID# 160672
🇵🇹Santa Maria Da Feira, Porto, Portugal
Duplicate_Hospital Garcia de Orta, EPE /ID# 160745
🇵🇹Almada, Setubal, Portugal
Centro Hospitalar Universitário do Algarve, EPE - Hospital Faro /ID# 160713
🇵🇹Faro, Portugal
Centro Hospitalar de Lisboa Ocidental, EPE - Hospital Egas Moniz /ID# 167751
🇵🇹Lisboa, Portugal
Unidade Local de Saude de Santa Maria, EPE /ID# 160692
🇵🇹Lisboa, Portugal
Centro Hospitalar de Lisboa Central /ID# 160673
🇵🇹Lisbon, Portugal
Hospital de Loures, E.P.E /ID# 207759
🇵🇹Loures, Portugal
Centro Hospitalar Universitario de Sao Joao, EPE /ID# 160693
🇵🇹Porto, Portugal
Centro Hosp de Tondela-Viseu /ID# 160699
🇵🇹Viseu, Portugal
Kuzbass Regional Clinical Hospital /ID# 200962
🇷🇺Kemerovo, Kemerovskaya Oblast, Russian Federation
Novosibirski Gastrocenter /ID# 217552
🇷🇺Novosibirsk, Novosibirskaya Oblast, Russian Federation
Duplicate_Perm state medical university n.a. E.A. Vagner /ID# 207439
🇷🇺Perm, Permskiy Kray, Russian Federation
Duplicate_St. Petersburg State Pediatric Medical University /ID# 211978
🇷🇺Saint Petersburg, Sankt-Peterburg, Russian Federation
Professor Pasechnikov Gastroenterology and Pankreatology clinic /ID# 200970
🇷🇺Stavropol, Stavropol Skiy Kray, Russian Federation
Tver Regional Clinical Hospital /ID# 206858
🇷🇺Tver, Tverskaya Oblast, Russian Federation
Regional Clinical Hospital #1 /ID# 200973
🇷🇺Tyumen, Tyumenskaya Oblast, Russian Federation
Alliance Biomedical Ural Group /ID# 200972
🇷🇺Izhevsk, Udmurtskaya Respublika, Russian Federation
National Medical Research Center of Coloproctology n.a. A. N. Ryzhikh /ID# 204808
🇷🇺Moscow, Russian Federation
City Clinical Hospital No. 31 /ID# 208872
🇷🇺St. Petersburg, Russian Federation
Ulyanovsk Regional Clinical Hospital /ID# 200964
🇷🇺Ulyanovsk, Russian Federation
Clinical Hosp Center Zvezdara /ID# 157052
🇷🇸Belgrade, Beograd, Serbia
Military Medical Academy /ID# 157053
🇷🇸Belgrade, Beograd, Serbia
University Children's Hospital 'Tirsova' /ID# 211482
🇷🇸Belgrade, Beograd, Serbia
University Clinical Center Serbia /ID# 157047
🇷🇸Belgrade, Beograd, Serbia
Clinical Hospital Center Dr Dragisa Misovic - Dedinje /ID# 212799
🇷🇸Belgrade, Beograd, Serbia
Clin Hosp Ctr Bezanijska Kosa /ID# 157050
🇷🇸Belgrade, Beograd, Serbia
General Hospital Leskovac /ID# 209575
🇷🇸Leskovac, Jablanicki Okrug, Serbia
Duplicate_University Clinical Center Kragujevac /ID# 157049
🇷🇸Kragujevac, Sumadijski Okrug, Serbia
University Clinical Center Vojvodina /ID# 157046
🇷🇸Novi Sad, Serbia
Gastroenterology and Liver Specialist Clinic /ID# 205741
🇸🇬Singapore, Central Singapore, Singapore
Singapore General Hospital /ID# 160668
🇸🇬Singapore, Singapore
Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 156468
🇸🇰Banska Bystrica, Banskobystricky Kraj, Slovakia
KM Management, spol. s.r.o. /ID# 206764
🇸🇰Nitra, Nitriansky Kraj, Slovakia
Gastro I., s.r.o. /ID# 156469
🇸🇰Prešov, Presovsky Kraj, Slovakia
Clinresco Centers /ID# 163865
🇿🇦Johannesburg, Gauteng, South Africa
Wits Clinical Research /ID# 158114
🇿🇦Johannesburg, Gauteng, South Africa
Spoke Research Inc /ID# 158116
🇿🇦CAPE TOWN Milnerton, Western Cape, South Africa
Private Practice Dr MN Rajabally /ID# 163112
🇿🇦Cape Town, Western Cape, South Africa
Hospital Arquitecto Marcide - Complejo Hospitalario Universitario de Ferrol /ID# 157553
🇪🇸Ferrol, A Coruna, Spain
Hospital Universitari de Bellvitge /ID# 208207
🇪🇸L'Hospitalet de Llobregat, Barcelona, Spain
Consorci Corporacio Sanitaria Parc Tauli Sabadell /ID# 159237
🇪🇸Sabadell, Barcelona, Spain
Hospital Universitario Puerta de Hierro - Majadahonda /ID# 157573
🇪🇸Majadahonda, Madrid, Spain
Hospital Universitario Basurto /ID# 205190
🇪🇸Bilbao, Vizcaya, Spain
Hospital Clinic de Barcelona /ID# 157552
🇪🇸Barcelona, Spain
Hospital General Universitario Gregorio Maranon /ID# 161145
🇪🇸Madrid, Spain
Hospital Universitario La Paz /ID# 159235
🇪🇸Madrid, Spain
Hospital Universitario de Salamanca /ID# 157558
🇪🇸Salamanca, Spain
Hospital Universitario Virgen Macarena /ID# 159967
🇪🇸Sevilla, Spain
Hospital Clinico Universitario de Valencia /ID# 209700
🇪🇸Valencia, Spain
Hospital Universitario y Politecnico La Fe /ID# 157556
🇪🇸Valencia, Spain
Hospital Clinico Universitario Lozano Blesa /ID# 212525
🇪🇸Zaragoza, Spain
Hospital Universitario Miguel Servet /ID# 157557
🇪🇸Zaragoza, Spain
Skane University hospital /ID# 211745
🇸🇪Malmo, Skane Lan, Sweden
Karolinska University Hospital Solna /ID# 212025
🇸🇪Solna, Stockholms Lan, Sweden
GHP Stockholm Gastro Center /ID# 211748
🇸🇪Stockholm, Stockholms Lan, Sweden
Medicinkliniken, Gastroenheten /ID# 163744
🇸🇪Stockholm, Stockholms Lan, Sweden
Danderyd Hospital /ID# 202138
🇸🇪Stockholm, Stockholms Lan, Sweden
Duplicate_Sahlgrenska University Hospital /ID# 163792
🇸🇪Gothenburg, Vastra Gotalands Lan, Sweden
Duplicate_Sahlgrenska University Hospital /ID# 163797
🇸🇪Gothenburg, Vastra Gotalands Lan, Sweden
Universitätsspital Basel /ID# 164554
🇨🇭Basel Town, Basel-Stadt, Switzerland
University Hospital Zurich /ID# 163536
🇨🇭Zurich, Zuerich, Switzerland
Inselspital, Universitaetsspital Bern /ID# 163535
🇨🇭Bern, Switzerland
National Taiwan University Hospital /ID# 162190
🇨🇳Taipei City, Taipei, Taiwan
China Medical University Hospital /ID# 160141
🇨🇳Taichung, Taiwan
Taichung Veterans General Hospital /ID# 160140
🇨🇳Taichung, Taiwan
National Cheng Kung University Hospital /ID# 160142
🇨🇳Tainan, Taiwan
Taipei Veterans General Hosp /ID# 212712
🇨🇳Taipei, Taiwan
Lviv Railway Clinical Hospital of branch Healthcare Centers of Public Joint Stoc /ID# 165658
🇺🇦Lviv, Lvivska Oblast, Ukraine
CNE Vinnytsya Regional Clinical Hospital named after N.I.Pirogov /ID# 216474
🇺🇦Vinnytsia, Vinnytska Oblast, Ukraine
?linic Scientific Research Inst of Invalid Rehab ESM? M I Pyrogov VNMU /ID# 212000
🇺🇦Vinnytsia, Vinnytska Oblast, Ukraine
ME Volyn Regional Clinical Hospital of Volyn Regional Council /ID# 206789
🇺🇦Lutsk, Volynska Oblast, Ukraine
Transcarpathian Regional Clinical Hospital n.a. Andriy Novak /ID# 167960
🇺🇦Uzhgorod, Zakarpatska Oblast, Ukraine
Kharkiv City Clinical Hospital No.2 n.a. Prof. O.O. Shalimov /ID# 165657
🇺🇦Kharkiv, Ukraine
Municipal Nonprofit Enterprise Kherson city clinical hospital n.a. Y.Y. Karabel /ID# 212399
🇺🇦Kherson, Ukraine
Kyiv City Clinical Hospital No.18 /ID# 162531
🇺🇦Kyiv, Ukraine
Medical Center OK Clinic LLC, International Institute of Clinical Research /ID# 211998
🇺🇦Kyiv, Ukraine
Communal Noncommercial Institution Consultative and Diagnostic Center of Desnian /ID# 165659
🇺🇦Kyiv, Ukraine
Addenbrooke's Hospital /ID# 158034
🇬🇧Cambridge, Cambridgeshire, United Kingdom
Duplicate_Royal Devon University Healthcare NHS Foundation Trust /ID# 157544
🇬🇧Exeter, Devon, United Kingdom
Hull University Teaching Hospitals NHS Trust /ID# 158761
🇬🇧Hull, East Riding Of Yorkshire, United Kingdom
Barts Health NHS Trust /ID# 163713
🇬🇧London, Greater London, United Kingdom
Guys and St Thomas NHS Foundation Trust /ID# 157546
🇬🇧London, Greater London, United Kingdom
Oxford University Hospitals NHS Foundation Trust /ID# 158036
🇬🇧Oxford, Oxfordshire, United Kingdom
NHS Greater Glasgow and Clyde /ID# 202568
🇬🇧Glasgow, Scotland, United Kingdom
Ashford and St Peter's Hospitals NHS Foundation Trust /ID# 207936
🇬🇧Chertsey, Surrey, United Kingdom
Leeds Teaching Hospitals NHS Trust /ID# 157550
🇬🇧Leeds, West Yorkshire, United Kingdom
Barnsley Hospital NHS Foundation Trust /ID# 202773
🇬🇧Barnsley, United Kingdom
University Hospitals Birmingham NHS Foundation Trust /ID# 157545
🇬🇧Birmingham, United Kingdom
NHS Lothian /ID# 207448
🇬🇧Edinburgh, United Kingdom
Calderdale and Huddersfield NHS Foundation Trust /ID# 209570
🇬🇧Huddersfield, United Kingdom
King's College Hospital NHS Foundation Trust /ID# 158760
🇬🇧London, United Kingdom
The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 163708
🇬🇧Newcastle upon Tyne, United Kingdom
Northern Care Alliance NHS Group /ID# 207766
🇬🇧Salford, United Kingdom