Correlation Between the Serum Chloride Levels and the Anion Gap Values in the Initial Fluid Resuscitation in DKA Patients and Its Relation to Outcome
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 54
- 试验地点
- 1
- 主要终点
- 1-Change in serum chloride levels before and after fluid resucitation in DKA patients. 2- change in anion gap level before and after fluid resuscitation in DKA patients.
研究概览
简要总结
2.2 Aim(s) of the Research (50 words max):
- To examine the description and correlation of changes in the serum chloride levels and changes in the anion gap values before and after fluid resuscitation in patients with DKA and to examine the description and correlation of changes in the serum chloride.
- relation of serum chloride and outcome in patients with DKA
详细描述
Diabetic ketoacidosis (DKA) is one of the most serious and acute complications of diabetes. DKA is a significant contributor to mortality, costs, and poor quality of life.
The total incidence of DKA tends to increase, mainly due to an increase in type 2 diabetes cases and obesity.
DKA consists of the biochemical triad of hyperglycemia, ketonemia, and metabolic acidosis resulting from absolute or relative insulin deficiency and an increase in counter-regulatory hormones. These life-threatening consequences produce severe body water deficit, the accumulation of ketone bodies, and electrolyte disturbances.
Hyperglycemia develops because of three processes: increased gluconeogenesis, accelerated glycogenolysis, and impaired glucose utilization by peripheral tissues. The hyperglycemia will lead to glycosuria and osmotic diuresis, resulting in hyperosmolar intracellular dehydration.
In DKA, fluid deficits may be up to 10% of total body weight and electrolyte deficits in the body, one of which is chloride.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 15 Years 至 70 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •any patients admitted to intensive care unit, critical care unit in Assuit university from 15 yrs to 70
- •Blood glucose level >250 mg/dl ( normal 70-100)
- •Ph<7.3 ( normal PH 7.35- 7.45)Hco3<15 m mol/litre ( normal HCO3 22-26)
- •Serum chloride before resucitation <107m mol/litre (normal 96- 106)
- •Urea <6.5 m mol/litre
- •S.create <120 m mol/litre
排除标准
- •Patients receiving chemotherapy, diuretics, corticosteroids, laxatives
- •Patients diagnosed to have Addison disease
- •Patients with chronic kidney disease and acute kidney injury, end stage renal disease, renal tubular acidosis
- •Patients with malabsorpion syndrome ( celiac disease, crohn's , celiac disease )
- •Patients with chronic respiratory acidosis (asthma, COPD, pulmonary fibrosis, neuromuscular disorders)
- •Patients with diarrhea
结局指标
主要结局
1-Change in serum chloride levels before and after fluid resucitation in DKA patients. 2- change in anion gap level before and after fluid resuscitation in DKA patients.
时间窗: 2 years
1. change in serum chloride level before and after fluid resuscitation in DKA patients. 2. change in anion gap level before and after fluid resuscitation in DKA patients.
次要结局
未报告次要终点
研究者
Mervat Mokhles Fathi Sayed
Doctor
Assiut University