Hop Compounds on the Immune System (VH)

Not Applicable

Recruiting

• Conditions: Inflammatory Response
• Interventions: Dietary Supplement: Xanthohumol + Iso-alpha-Acids; Dietary Supplement: Xanthohumol; Dietary Supplement: Iso-alpha-Acids

• Registration Number: NCT06286644
• Lead Sponsor: University of Vienna

Brief Summary

The aim of the present study is to determine the effect of Iso-alpha-Acids and Xanthohumol from hops on the immune response of healthy participants over a timeframe of 6 hours.

Detailed Description

In this placebo-controlled crossover study a study drink enriched with either a placebo, Xanthohumol, Iso-alpha Acids or a combination of latter is given to the participants. A washout phase before intervention and between each intervention is introduced. On day one of each intervention blood is drawn in fasted state from each participant. Subsequently the study drink combined with a standardized breakfast is given to the participants followed by blood draws 1, 2, 3, 4 and 6 hours after the consumption of the study drink. To assess the effect of Xanthohumol and Iso-alpha acids or a combination of both, clinical parameters, blood lipids, blood glucose, uric acid and inflammatory markers will be determined. Furthermore, blood cells, isolated from blood samples of each time point, will be stimulated for measuring inflammatory markers.

Study Timeline

• Study Start: 2022-05-30
• Study First Submitted: 2024-01-17
• Study First Submitted QC: 2024-02-21
• Study First Posted: 2024-02-29
• Status Verified: 2025-04
• Last Update Submitted: 2025-04-10
• Last Update Posted: 2025-04-15
• Primary Completion: 2025-10-31
• Study Completion: 2025-12-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 14

Inclusion Criteria

• healthy
• BMI: >18,5 kg/m² or <30 kg/m²

Exclusion Criteria

• food intolerances
• food allergies
• chronic inflammatory diseases
• metabolic diseases
• viral or bacterial infections within the last 3 weeks of inclusion
• intake of immunosuppressive medication

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Xanthohumol/Iso-alpha-Acids	Xanthohumol + Iso-alpha-Acids	Participants receive a study drink supplemented with Xanthohumol + Iso-alpha-Acids (0 mg = Placebo; 0,125 mg + 15 mg, 0,375 mg + 45 mg or 0,75 mg + 90 mg soluble Xanthohumol + Iso-alpha-Acids)
Xanthohumol	Xanthohumol	Participants receive a study drink supplemented with Xanthohumol (0mg = Placebo; 0,125 mg; 0,375 mg or 0,75 mg soluble Xanthohumol)
Iso-alpha-Acids	Iso-alpha-Acids	Participants receive a study drink supplemented with Xanthohumol (0 mg = Placebo; 15 mg, 45 mg or 90 mg Iso-alpha-Acids)

Primary Outcome Measures

Name	Time	Method
Changes in parameters of immune response	6 hours	Changes in concentration of interleukin 1 beta (ng/ml) in cell culture supernatant of stimulated cells.

Trial Locations

Locations (1)

University of Vienna; 🇦🇹 Vienna, Austria