跳至主要内容
临床试验/EUCTR2010-023455-28-FI
EUCTR2010-023455-28-FI进行中(未招募)不适用

Dexmedetomidine pharmacokinetics during continuous venovenous hemofiltration and hemodiafiltration in critically ill patients - Dexmedetomidine study

Maija Kaukonen0 个研究点目标入组 10 人开始时间: 2010年11月3日最近更新:
适应症
相关药物

试验速览

阶段
不适用
状态
进行中(未招募)
发起方
入组人数
10

研究概览

简要总结

暂无简介。

研究设计

研究类型
Interventional clinical trial of medicinal product

入排标准

性别
All

入选标准

  • 1. age = 18
  • 2. clinical need for sedation
  • 3. acute kidney injury requiring renal replacement therapy (according to ICUs standard operating procedures, one or more of the following criteria)
  • -oliguria (diuresis < 200ml/12h) or anuria
  • -severe acidosis (pH < 7.1-7.2) or rapidly deteriorating acidosis
  • -hyperpotassemia
  • -urea > 30 mmol/l and/or creatinine >500 umol/l or uremic complications (encephalopatia, pericarditis)
  • -significant fluid retention (high IAP, pulmonary oedema, severe peripheral oedema)
  • -rhabdomyolysis
  • -especially the combination of oliguria and deteriorating acidosis and/or hyperpotassemia is an indication for early initiation of renal replacement therapy
  • Are the trial subjects under 18? no
  • Number of subjects for this age range:
  • F.1.2 Adults (18-64 years) yes
  • F.1.2.1 Number of subjects for this age range
  • F.1.3 Elderly (>=65 years) yes
  • F.1.3.1 Number of subjects for this age range

排除标准

  • 1. Severe bradycardia (HR<50/min)
  • 2. AV conduction block II-III (unless pacemaker installed)
  • 3. Severe hepatic impairment (bilirubin >101 umol/l)
  • 4. Pregnancy or lactation
  • 5. Age <18

研究者

发起方
Maija Kaukonen

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