Is the gut microbiome associated with residual beta cell function in longstanding type 1 diabetes?
Recruiting
- Conditions
- Juvenile diabetestype 1 diabetes10018424
- Registration Number
- NL-OMON49369
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 500
Inclusion Criteria
Type 1 diabetes, >18 years old, visit outpatient clinic Amsterdam region,
ability to provide informed consent
Exclusion Criteria
- Active infection at the time of inclusion (not to influence T-cell function)
- Antibiotic or proton-pump inhibitor use last 3 months (not to influence
microbiome)
- Unwillingness to donate feces, urine and/or blood
- Inability to provide informed consent based on cognitive function, language
barrier or other reasons
- Absence of large bowel (ie colostomy).
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>2-hour post-meal urinary C-peptide / creatinine ratio as a validated marker of<br /><br>beta cell reserve in type 1 diabetes mellitus.</p><br>
- Secondary Outcome Measures
Name Time Method