NCT01798862已完成2 期
The Effect of Endometrial Injury on IVF Outcome Parameters in Patients With Repeated Implantation Failures
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 3
- 主要终点
- positive bHCG rate
研究概览
简要总结
The iatrogenic induction of local endometrial injury caused through hysteroscopy or pipelle sampling in the preceding non- transfer cycle improves the IVF outcome parameters in patients with previous IVF failures.
详细描述
Endometrial injury was preformed either through hysteroscope during office hysteroscopy through the non touch technique or through pipelle biopsy in the early follicular phase (days 5 to 9) in the preceding cycle of the IVF treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 25 Years 至 42 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Personal history of 2 or more failed IVF/ICSI cycles (RIF)
- •Age</= 42 years
- •Good response with good quality embryos in previous attempts (>2)
排除标准
- •Personal history of endometrial tuberculosis/ antituberculous treatment
- •Sonographically detected hydrosalpinges
- •Intramural fibroids distorting the endometrial cavity, submucous myomas or Asherman's syndrome
- •Thrombophilia
结局指标
主要结局
positive bHCG rate
时间窗: through study completion, an average of 2 years
次要结局
- live birth rate(2 years)
- clinical pregnancy rate(2 years)
- Pregnancy complications (preterm birth, placental abnormalities, bleeding throughout pregnancy, pregnancy related hypertensive disorders, IUGR and SGA)(2 years)
- Ectopic pregnancy rate(2 years)
- Miscarriage rate(2 years)
- Ongoing pregnancy rate(2 years)
研究者
Siristatidis Charalampos, MD, PhD
Assistant Professor in Obstetrics and Gynecology / Assisted Reproduction
National and Kapodistrian University of Athens
研究点 (3)
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