Transcriptomic Study of IBD-associated Colorectal Cancer
Completed
- Conditions
- Colorectal Cancer, Genetics of
- Registration Number
- NCT05060770
- Lead Sponsor
- Central Hospital, Nancy, France
- Brief Summary
Chronic inflammatory bowel disease (IBD) is associated with an increased risk of colorectal cancer (CRC) in historical cohorts. The pathways of oncogenesis of these CRCs, which are very different clinically from de novo CRCs, are currently unknown. The aim of our work is to identify specific molecular signatures of CRC occurring in the setting of IBD.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 26
Inclusion Criteria
- Person 18 years of age or older
- Person with colorectal cancer in the context of IBD
- Person who has received complete information on the organization of the research and who has signed an informed consent
- Person affiliated to a social security plan or beneficiary of such a plan.
Exclusion Criteria
- Person referred to in articles L. 1121-5, L. 1121-7 and L1121-8 of the public health code:
- Pregnant woman, parturient or nursing mother
- Minor (not emancipated)
- Adult person subject to a legal protection measure (guardianship, curatorship, safeguard of justice)
- Person of legal age who is unable to express his or her consent
- Person deprived of liberty by a judicial or administrative decision, persons subject to psychiatric care under articles L. 3212-1 and L. 3213-1.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method IBD associated CRC oncogenesis 1 year Percentage of gene expression variation in CRC tumor tissue samples in the following groups patients with CRC and IBD
- Secondary Outcome Measures
Name Time Method