Development of Sidhartaka Snanayoga ointment and comparing its effect with its lepa in hyperpigmentation in contact derrmatitis
Phase 3
- Conditions
- Health Condition 1: L249- Irritant contact dermatitis, unspecified cause
- Registration Number
- CTRI/2024/01/061024
- Lead Sponsor
- Government Ayurveda Medical College and Hospital, Thiruvananthapuram
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Participants diagnosed with hyperpigmentation associated with localised, subacute contact dermatitis
Subacute contact dermatitis: crusts, scales, and hyperpigmentation
Exclusion Criteria
Severe conditions of Contact dermatitis with an extensive skin area involvement (greater than 20 percent)
Pregnant women and lactating mothers
Under medications of antibiotics, steroids and topical steroids
Patients diagnosed with severe systemic disorders
Already diagnosed with or a history of other skin conditions such as psoriasis
Drug induced bullous disorders
Tinea corporis
Contact urticaria syndrome
Asteatotic eczema
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method HyperpigmentationTimepoint: Assessment will be done on the 0th day, 16th day and 31st day
- Secondary Outcome Measures
Name Time Method Histopathological changes such as <br/ ><br>Scale crust in stratum corneum <br/ ><br>Orthokeratosis or Parakeratosis <br/ ><br>Acanthosis <br/ ><br>Acantholysis <br/ ><br>Spongiosis <br/ ><br>Pyknosis <br/ ><br>Intra epithelial neutrophils & eosinophils <br/ ><br>Epidermal necrosis <br/ ><br>Micro abscess <br/ ><br>Melano phages <br/ ><br>Edema of papillary dermis <br/ ><br>Perivascular infiltrate of lymphocytes <br/ ><br>Timepoint: 0th day & 31st day from a subset of 6 participants from each group