Peking University Birth Cohort in Weifang
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 2,800
- 试验地点
- 1
- 主要终点
- Numbers and morbidity of participants with adverse pregnancy outcomes
研究概览
简要总结
The PKUBC-WF is a prospective cohort study carried out in Weifang city of Shandong, China. The primary aim of this study is to investigate the short-term and long-term effects of pre-pregnant and prenatal exposure on maternal and child health. Data are collected regarding environmental, nutritional and lifestyle exposures as well as short-term and long-term health outcomes of mothers and their children from birth to before 18 years old. Biological samples including peripheral blood, urine, placenta, umbilical cord, cord blood, and faeces are also collected.
详细描述
Maternal and child health is of great concern globally. Early life phase of a fetus and infant is a critical period for the development of health and disease in the whole life. Exposure of negative environmental, nutritional and lifestyle factors in pregnant women during this period can have adverse effects on fetal and infant. In addition, for mothers, complications during pregnancy could also have a negative effect on long-term health of mothers, such as diabetes, hypertension. Thus, the Peking University Birth Cohort in Weifang is primarily aimed to investigate the short-term and long-term effects of pre-pregnant and prenatal exposure on maternal and child health. Data are collected regarding environmental, nutritional and lifestyle exposures as well as short-term and long-term health outcomes of mothers, husbands and their children from birth to before 18 years old. Biological samples including peripheral blood, urine, placenta, umbilical cord, cord blood, and faeces samples are also collected.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Pregnant woman
- •Pregnant women, 6-13^+6 gestational weeks
- •Resided in Weifang in the past half years and have no plan to move out after delivery
- •Pregnant women who plan to have antenatal care and delivery in Weifang maternal&Child Hospital.
- •Pregnant women who is willing to participate in this study with informed consent
- •Pregnant woman's husband
- •His wife was eligible for enrollment
- •He is the biological father of the child (his wife's current pregnancy)
- •Pregnant women's husband who is willing to participate in this study with informed consent
- •Offspring
- •Children born to pregnant women who met the inclusion criteria after enrolling in this study.
- •5. Before the age of 8 years, his/her mother provided written informed consent.
- •After 8 years old, he/she agreed to continue this study and signed the informed consent.
排除标准
- •Participants who cannot communicate normally.
结局指标
主要结局
Numbers and morbidity of participants with adverse pregnancy outcomes
时间窗: At delivery
Including preterm birth, low birth weight, macrosomia, abortion, stillbirth, and birth defects.
Numbers and morbidity of participants with pregnancy complications
时间窗: At delivery
Including gestational diabetes, gestational hypertension, anemia, and hypothyroidism during pregnancy
次要结局
- Incidence of attention-deficit/hyperactivity disorder in children(Age at 6 years)
- Incidence of diabetes mellitus in women(6 weeks after delivery and 3 years after delivery)
- Weight in kilogram changes during childhood(At birth and age at 6 weeks, 6 months, 12 months, 2 years, 3 years, 6 years, 9 years, 12 years, 15 years, and 17 years)
- Incidence of autism spectrum disorder in children(Age at 2 years, 3 years)
- Incidence of anxiety in adolescents(Age at 9 years, 12 years, 15 years, and 17 years)
- Height in centimeter changes during childhood(At birth and age at 6 weeks, 6 months, 12 months, 2 years, 3 years, 6 years, 9 years, 12 years, 15 years, and 17 years)
- Early Child development(Age at 6 weeks, 6 months and 12 months)
- Incidence of hypertension in women(6 weeks after delivery and 3 years after delivery)
- Incidence of child overweight and obesity(At birth and age at 6 weeks, 6 months, 12 months, 2 years, 3 years, 6 years, 9 years, 12 years, 15 years, and 17 years)
- Incidence of depression in adolescents(Age at 9 years, 12 years, 15 years, and 17 years)
研究者
Hai-Jun Wang
Prof.
Peking University