Birth Cohort Study of China Medical University in Shenyang
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- Change of biometric parameter in centimeter of fetuses at the thirteenth week of gestational age
研究概览
简要总结
The CMUBCS is a birth cohort study located in Shenyang, China. Its initial aim is to facilitate research on understanding the interplay between genes and environmental factors on disease etiology. Data are collected regarding environmental factors, family and lifestyle, clinical experimental outcomes and imaging results of pregnant women and children from birth to 18 years old. Biological samples including blood and tissue samples are also collected from the children and their parents.
详细描述
Early life phase (fetal and infant) is a critical period for the development of health and disease in a person's life. Many adult chronic diseases, such as diabetes, cardiovascular and cerebrovascular diseases, all come from the exposure of negative environmental and behavioral factors during this period. By collecting the lifestyle data and clinical data of pregnant women at different periods, the appropriate indicators are anticipated to be selected to predict and evaluate the outcome of pregnancy and the health of the mothers and children in the long term. The status of overweight and obesity of children in Shenyang and its surrounding areas are anticipated to be analyzed by descriptive and etiological analysis through collecting the lifestyle data and clinical data of different periods of pregnant women and the lifestyle data of different developmental stages of children.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Pregnant women, <13 gestational weeks
- •Permanent residents or families intended to remain in Shenyang and surrounding areas
- •Pregnant women who are planned to be examined and delivered in Shengjing Hospital.
排除标准
- •Pregnant women who refuse to take part in the study
- •Pregnant women have diseases that might affect the results of researches, including neuropsychiatric disorders.
结局指标
主要结局
Change of biometric parameter in centimeter of fetuses at the thirteenth week of gestational age
时间窗: At every week from the thirteenth week of gestational age to delivery of babies
Including head circumference, abdominal circumference, biparietal diameter, femur length of singleton and twin pregnancy
Weight in kilogram of neonate
时间窗: At birth of neonate
Including singleton and twin pregnancy measured by nurses
Gene expression of husbands of pregnancy women
时间窗: At 13 weeks of gestational age
DNA methylation, histone acetylation etc. assessed by analyses of blood
Result of Non-invasive Prenatal Testing
时间窗: From 12 to 22 weeks of gestational age
including singleton and twin pregnancy
Change of gene expression of pregnancy women
时间窗: At 13, 26 and 34 weeks of gestational age
DNA methylation, histone acetylation etc. assessed by analyses of blood
次要结局
- Change of intestinal flora during early childhood(Age at 1 year, 3 years, 6 years, 9 years, 12 years, 15 years and 18 years)
- Weight in kilogram changes during childhood(Age at 1 year, 3 years, 6 years, 9 years, 12 years, 15 years and 18 years)
- Height in centimeter changes during childhood(Age at 1 year, 3 years, 6 years, 9 years, 12 years, 15 years and 18 years)
- Change of gene expression during childhood(Age at 1 year, 3 years, 6 years, 9 years, 12 years, 15 years and 18 years)
研究者
Caixia Liu
Director of the second obstetrical department
Shengjing Hospital