Twins Born in Guangzhou Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- Change of gene expression during childhood
研究概览
简要总结
The 2-BIG is a twin birth cohort study located in Guangzhou, China.Its initial aim is to facilitate research on understanding the interplay between genes and environmental factors on disease etiology. Data are collected regarding environmental, family and lifestyle exposures on twins from birth to 18 years old. Biological samples including blood and tissue samples are also collected from the twins and their parents.
详细描述
Twins share the same intrauterine environment and the early family environment. When conducting research of chronic disease etiology, twins cohort can be a good control of bias from age, gender, genetic and early environment. Twin-based designs provide an estimate of the relative contribution of genetic and non-genetic factors to a specific phenotype. Twins study has an advantage of calculating heritability of traits. Since heritability of traits is various from different populations. It is important to establish database to calculate the heritability of traits associated with chronic major diseases in Chinese population. Twins cohort is rare in China at present. Therefore, extensive information including physical characteristics, mental health, and behaviors is collected from both twins and their parents. Longitudinal follow-up and surveillance of common diseases are also to be conducted. The 2-BIG aims to explore epigenetic markers and genes related to health status, as well as gene-environment interactions on diseases, both in intrauterine and childhood stages, especially in Chinese population.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- — 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Live twins delivered in Guangzhou Women and Children's Medical Center
- •Permanent residents or families intended to remain in Guangzhou with their children for no less than 3 years
- •Baseline information during pregnancy available
排除标准
- 未提供
结局指标
主要结局
Change of gene expression during childhood
时间窗: Age at 1 year , 6 years, 12years and 18years
DNA methylation, histone acetylation etc. assessed by analyses of blood samples
Intelligence quotient
时间窗: At age of 6 years old
Assessed using the Wechsler Preschool and Primary Scale of Intelligence-Fourth Edition including 5 verbal and 3 performance subtests. Intelligence quotient ranges 40-160, in which under 70 is defined as mental retardation. The total score was calculated by an online system.
Neurodevelopment at early childhood
时间窗: At age of 1 year old
Including adaptive, gross motor, fine motor, language, and social function; assessed using Gesell Developmental Schedules.
次要结局
- Change of intestinal flora during early childhood(Age at 6 weeks, 6 months, 1 year , 3 years,6 years, 12years and 18years)
- Height in kilometer changes during childhood(At birth, age of 6 weeks, 6 months, 1 year, 3 years,6 years, 12years and 18year)
- Changes of body composition and bone density during early childhood(At birth, age of 6 weeks, 6 months, 1 year , 3 years,6 years, 12years and 18years)
- Weight in kilogram changes during childhood(At birth, age of 6 weeks, 6 months, 1 year, 3 years,6 years, 12years and 18year)
研究者
Xiu Qiu
Director of the Born in Guangzhou Cohort Study
Guangzhou Women and Children's Medical Center