The Born in Guangzhou Cohort Study (BIGCS)
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Intrauterine Hyperglycemia
- Sponsor
- Guangzhou Women and Children's Medical Center
- Enrollment
- 30000
- Locations
- 1
- Primary Endpoint
- Number of participant with pregnancy outcomes
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
The Born in Guangzhou Cohort Study (BIGCS) was established to investigate the short- and long-term effects of exposure in early life on health consequences in Guangzhou, China. Data are collected regarding environmental, occupational and lifestyle exposures as well as health outcomes in later life. Biological samples including blood and tissue samples are also collected from the participants.
Detailed Description
Over the past three decades, China is undergoing rapidly economic development. At the same time, the Western diet and urban lifestyle has been more common than before, which may lead to an increase of incidence of non-communicable chronic diseases, such as diabetes and malignancies. Notably, the current generation of Chinese adults, particularly those in their middle age or older, were born in an era where hardship and rationing was the norm and witnessed a social and epidemiological transition that might have a profound effect on their present health. In contrast, the younger generation is raised in relative material abundance, under the influence of traditional Chinese values such as a strong family orientation and an emphasis on academic success. A birth cohort with would provide an opportunity to examine the short- and long-term effects of exposure in early life on health consequences in this younger generation, in the context of rapid development in China.
Investigators
Xiu Qiu
Director of the Born in Guangzhou Cohort Study
Guangzhou Women and Children's Medical Center
Eligibility Criteria
Inclusion Criteria
- •Pregnant women with \<20 weeks of gestation
- •Pregnant women intended to eventually deliver in Guangzhou Women and Children's Medical Center
- •Permanent residents or families intended to remain in Guangzhou with their child for ≥3 years
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Number of participant with pregnancy outcomes
Time Frame: At delivery
Including abortion, stillbirth, live birth, preterm birth, low birth weight and birth defects
Secondary Outcomes
- Height changes during early childhood(At birth, age of 6 weeks, 6 months, 1 year and 3 years)
- Neurodevelopment during early childhood(At age of 3 years)
- Weight changes during early childhood(At birth, age of 6 weeks, 6 months, 1 year and 3 years)
- Changes of body composition during early childhood(At birth, age of 6 weeks, 6 months, 1 year and 3 years)