Maternal Grandmothers in the Born in Guangzhou Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 5,000
- 试验地点
- 2
- 主要终点
- Haplotypes transfered by non-inherited maternal antigens from maternal grandmother to female offspring
研究概览
简要总结
The MGBIG is a study exploring cross-generational effects in 5000 women and their children and grandchildren located in Guangzhou, China. Its initial aim is to facilitate research on understanding the interplay between genes and environmental factors on disease etiology and on explaining the cause of the disease from the perspective of "grandmother-mother-child" heredity. Data are collected regarding environmental exposures, lifestyle, and social support on grandmother from birth to old age. Biological samples including blood and tissue samples are collected.
详细描述
It was previously believed that heredity strictly follows Mendel's laws, but recent studies have found that through placental material exchange, mammals may transfer maternal immune-related factors vertically, thus promoting the protection of "non-heredited maternal antigenic traits". Thus, the transmission of reproductive information across generations is realized. Since the unusual genetic pattern of the X chromosome, grandmother's influence may be gender specific. Since grandchildren were usually took care by grandparents in China, it could be achievable to attach and recruit maternal grandmother together with mother and children. Cohort including three generations of women is rare in Asia at present. In the MGBIG, extensive information including demographic characteristics, lifestyle, history of diseases, mental health, and behaviors is collected from the participants. Longitudinal follow up and surveillance of common chronic diseases are also to be conducted. The MGBIG intends to recruit maternal grandmothers to study the effects of maternal genetic and environmental exposure on the health of their children and grandchildren.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 36 Years 至 100 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Maternal Grandmother' grandchildren delivered in Guangzhou Women and Children's Medical Center
- •Baseline information of maternal grandmother's daughter during pregnancy available
排除标准
- •Significant cardiovascular abnormalities
- •Intelligent obstacle, intellectual disabilities or gawkish condition
结局指标
主要结局
Haplotypes transfered by non-inherited maternal antigens from maternal grandmother to female offspring
时间窗: From the date of her daughter get pregnant until the date her grandchild/grandchildren is/are given birth
Assessed by analyses of MHC haplotypes, HLA haplotypes, and levels of non-inherited maternal antigens of mother and offspring, and pregnancy complication of maternal grandmothers and mothers
次要结局
- Changes of body composition of grandchildren(At age of 3 years,6 years, 12years and 18years)
- Serum levels of Inflammatory factors at grandchildren's birth and early neonatal life(At the birth date of her grandchild/grandchildren, at the date 42 days after the birth of the certain grandchild/grandchildren)
- The prevalence of Allergic rhinitis of grandchildren(At the age of 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren)
- The incidence of asthma of grandchildren(At the age of 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren)
- The prevalence of Food allergy of children and grandchildren(At the age of 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren)
- The prevalence of eczema of grandchildren(At the age of 6 weeks, 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren)
- Changes of bone density of grandchildren(At age of 3 years,6 years, 12years and 18years)
研究者
Xiu Qiu
Director of the Born in Guangzhou Cohort Study
Guangzhou Women and Children's Medical Center