Risk Evaluation by COronary CTA and Artificial intelliGence Based fuNctIonal analyZing tEchniques - I
- Conditions
- Coronary Artery Disease
- Registration Number
- NCT05884008
- Lead Sponsor
- Ruijin Hospital
- Brief Summary
This study is a multicenter, retrospective imaging study. The study intends to retrospectively enroll patients with acute myocardial infarction who had received coronary CTA in a certain time-window before this event. All coronary CTA will be analyzed by anatomic, functional and radiomic analysis, assisted by artificial intelligence. The purpose of this study is to establish a coronary artery disease risk stratification system by coronary CTA.
- Detailed Description
Coronary angiography has been the gold standard for the diagnosis of coronary heart disease and PCI decision-making. However, the value of CAG in risk stratification is limited due to its invasive nature and lack of ability to evaluate coronary physiology and plaque characteristics, which often leads to over-treatment or under-treatment. In recent years, with the development and improvement of imaging technology, the resolution and diagnostic accuracy of coronary artery CTA have been greatly improved, and the subsequent anatomy and function (non-invasive CT-FFR, etc.) have made the assessment of coronary artery lesion risk multi-dimensional. Comprehensive and accurate coronary artery CTA scan plays a positive role in establishing the appropriate standard for PCI and improving the prognosis of patients. However, the existing problems of coronary artery CTA are insufficient imaging studies, complex image analysis, inconsistent diagnostic criteria, and insufficient clinical evidence. This study is one of the series of clinical studies on the topic of "Risk Evaluation by COronary Computed Tomography and Artificial Intelligence Based fuNctIonal analyZing tEchniques (RECOGNIZE)". The purpose of the study is to establish a coronary artery disease risk stratification system by coronary CTA and anatomic, functional and radiomic analysis, assisted by artificial intelligence.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 300
- Age between 18-80 years old
- Received coronary CT angiography 3 months to 5 years prior to acute coronary myocardial infarction. CCTA identified coronary atherosclerotic plaques with diameter stenosis ≥ 10%
- Familial hypercholesterolemia
- Prior history of percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG)
- Prior history of myocardial infarction before the recent event
- Severe liver or renal insufficiency
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Coronary artery plaque risk level 3 months to 5 years prior to acute myocardial infarction Coronary plaque risk was determined using an artificial intelligence (AI) guided risk stratification model based on Coronary CTA structural, functional and radiomic analysis.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (9)
First affiliated hospital of Harbin Medical University
🇨🇳Harbin, Heilongjiang, China
Cangzhou Center Hospital
🇨🇳Cangzhou, Hebei, China
First affiliated hospital of Zhengzhou University
🇨🇳Zhengzhou, Henan, China
Union Hospital, Tongji Medical College, Huazhong University of Science and Techonology
🇨🇳Wuhan, Hubei, China
First affiliated hospital of Dalian Medical College
🇨🇳Dalian, Liaoning, China
First Hospital of Nanjing
🇨🇳Nanjing, Jiangsu, China
General Hospital of Northern Theater Command
🇨🇳Shenyang, Liaoning, China
Ruijin Hospital, Shanghai Jiaotong University School of Medicine
🇨🇳Shanghai, Shanghai, China
Xinhua Hospital, Shanghai Jiaotong University School of Medicine
🇨🇳Shanghai, Shanghai, China