Prevalence of Musculoskeletal Symptoms in the Cambridge NIHR BioResource

• Conditions: Musculoskeletal Diseases; Musculoskeletal Injury
• Interventions: Other: Questionnaire including MSK-HQ (Musculoskeletal Health Questionnaire)

• Registration Number: NCT04632563
• Lead Sponsor: Cambridge University Hospitals NHS Foundation Trust

Brief Summary

Musculoskeletal diseases, such as osteoarthritis, represent a large proportion of the global burden of disease with hip and knee osteoarthritis alone being the 11th greatest cause of disease burden.

The purpose of this study is to determine the level of musculoskeletal symptoms in members of the Cambridge National Institute for Health Research (NIHR) BioResource and see if this is associated with their possession of genetic markers that have been identified as being associated with osteoarthritis.

This will allow us to determine the real level of musculoskeletal symptoms in this large cohort of volunteers and provide basic information that could be used to facilitate further musculoskeletal research in the NIHR BioResource population.

Detailed Description

All active members of the Cambridge NIHR BioResource will be approached.

They will be sent an email outlining the purpose of the study and asking that if they would like to take part to please complete the online questionnaire which will be linked to in the email.

For those individuals who agree to participate and complete the questionnaire, the Cambridge NIHR BioResource will provide the genetic marker information it already holds for specific markers that are known to be associated with osteoarthritis.

Study Timeline

• Status Verified: 2020-11
• Study Start: 2020-11
• Study First Submitted: 2020-11-11
• Study First Submitted QC: 2020-11-11
• Last Update Submitted: 2020-11-11
• Study First Posted: 2020-11-17
• Last Update Posted: 2020-11-17
• Primary Completion: 2021-04
• Study Completion: 2021-08

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 5000

Inclusion Criteria

• Member of the NIHR BioResource
• Willing to consent to participate

Exclusion Criteria

• Previous self-report of osteoarthritis on joining BioResource

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Member of BioResource	Questionnaire including MSK-HQ (Musculoskeletal Health Questionnaire)	Any BioResource member who consents to take part in the study and completes the study questionnaire.

Primary Outcome Measures

Name	Time	Method
MSK Symptom Levels	3 months	Musculoskeletal Symptoms in respondents
Osteoarthritis genetic marker	6 months	Possession (or not) of specific genetic markers for osteoarthritis (obtained from information already held by the NIHR BioResource)

Secondary Outcome Measures

Name	Time	Method
MSK Cohort	6 months	Identification of those with particular musculoskeletal injuries and conditions for future studies