MedPath

A Study to Investigate the Safety and Efficacy of mRNA-1403 in Participants ≥18 Years of Age for the Prevention of Acute Gastroenteritis

Phase 3
Recruiting
Conditions
Acute Gastroenteritis
Norovirus Acute Gastroenteritis
Interventions
Biological: Placebo
Registration Number
NCT06592794
Lead Sponsor
ModernaTX, Inc.
Brief Summary

The primary objectives of this study are to evaluate the safety and reactogenicity of mRNA-1403, and to demonstrate the efficacy of mRNA-1403 to prevent protocol-defined moderate or severe norovirus acute gastroenteritis (AGE) associated with vaccine matched genotypes.

Detailed Description

Not available

Recruitment & Eligibility

Status
RECRUITING
Sex
All
Target Recruitment
25000
Inclusion Criteria
  1. Participants who understand and are willing and physically able to comply with protocol mandated follow-up, including all procedures as assessed by the Investigator, and who are primarily responsible for their self-care and activities of daily living.

  2. Participants may have chronic medical diagnoses but should be medically stable as assessed by the following criteria:

    • Absence of medical events associated with underlying diagnoses and qualifying as SAEs within 1 month prior to study intervention on Day 1.
    • Absence of known, current, and life-limiting diagnoses, which could continue for the duration of the study and which, in the opinion of the Investigator, would make completion of the protocol unlikely.
  3. Capable of giving signed informed consent, which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in the protocol.

  4. Participants assigned female at birth are eligible to participate if they are not pregnant or breastfeeding/chestfeeding/bodyfeeding and meet protocol defined criteria.

Exclusion Criteria
  1. Participant is acutely ill or febrile (temperature ≥38.0 degrees Celsius (°C) [100.4 degrees Fahrenheit [°F]) 72 hours prior to or at the Screening Visit or Day 1.
  2. History of AGE within 14 days prior to Day 1 or close contact with an individual with AGE symptoms (in the home, socially, or occupationally) within 14 days prior to Day 1.
  3. History of a diagnosis or condition that in the judgment of the Investigator, is clinically unstable or may affect participant safety, assessment of safety endpoints, assessment of immune response, or adherence to study procedures.
  4. Current diagnosis of chronic gastrointestinal (GI) disease that is associated with ongoing symptoms of regular vomiting and/or diarrhea. Participants with stable, well-controlled chronic GI disease without regular vomiting and/or diarrhea can be considered for enrollment.
  5. Has a medical, psychiatric, or occupational condition that may pose additional risk as a result of participation or that could interfere with safety assessments or interpretation of results according to the investigator's judgment.
  6. Has undergone surgical procedures within 7 days prior to Day 1 or is scheduled to undergo a surgical procedure within 28 days after study intervention.
  7. Reported history of congenital or acquired immunodeficiency, immunocompromising/immunosuppressive condition, asplenia, or recurrent severe infections per protocol.
  8. Reported history of anaphylaxis, urticaria, or other significant AR requiring medical intervention after receipt of a vaccine or intervention that includes one or more of the same components contained in the study vaccine.
  9. History of myocarditis, pericarditis, or myopericarditis with onset within 180 days prior to Day 1 whose values have not returned to Baseline clinical status.
  10. History of Guillain-Barré syndrome.
  11. Reported history of coagulopathy or bleeding disorder considered a contraindication to IM injection or phlebotomy.
  12. Dermatologic conditions that could affect local solicited AR assessments.
  13. Diagnosis of malignancy within the previous 2 years (excluding nonmelanoma skin cancer).
  14. Has received systemic immunosuppressive therapies for >14 days in total within 6 months prior to Day 1 (for corticosteroids ≥10 milligrams (mg)/day of prednisone equivalent) or is anticipating the need for immunosuppressive treatment at any time during participation in the study.
  15. Has received or plans to receive any licensed vaccine ≤28 days prior to or within 28 days after study intervention (Day 1), except for influenza vaccines, which may be given 14 days before or after receipt of a study intervention.
  16. Receipt of systemic immunoglobulins or blood products within 3 months prior to Day 1 or plans for receipt during the study.
  17. Has donated ≥450 mL of blood products within 28 days prior to Day 1 Visit or plans to donate blood products during the study.
  18. Participated in a clinical study with investigational treatment within 90 days prior to Day 1 (Baseline) based on the medical history interview or plans to do so while participating in this study. Participants may continue in prior interventional study follow-up activities, provided that it does not involve further investigational treatment and/or procedures that may affect safety and/or other study endpoints, and study participation does not result in a breach of either study protocol.
  19. Is working as, has worked as, or is an immediate family member or household member of study personnel, Sponsor personnel, or study site staff directly involved with the conduct of the study.

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
mRNA-1403mRNA-1403Participants will receive a single injection of mRNA-1403 on Day 1.
PlaceboPlaceboParticipants will receive a single injection of mRNA-1403 matching placebo (0.9% sodium chloride solution) on Day 1.
Primary Outcome Measures
NameTimeMethod
Number of Participants with Solicited Local and Systemic Adverse Reactions (ARs)Day 1 up to Day 7 (7 days after study intervention)
Number of Participants with Unsolicited Adverse Events (AEs)Day 1 up to Day 28 (28 days after study intervention)
Number of Participants with Medically Attended Adverse Events (MAAEs)Day 1 through Day 181
Number of Participants with Serious Adverse Events (SAEs), AEs of Special Interest (AESIs), and AEs Leading to Study WithdrawalDay 1 through Day 730
Vaccine Efficacy (VE) of mRNA-1403 to Prevent First Occurrence of Protocol-defined Moderate or Severe AGE Associated with Vaccine Matched GenotypesDay 15 through Day 730
Secondary Outcome Measures
NameTimeMethod
Geometric Mean Fold Rise (GMFR) of HBGA-blocking Antibodies Titers Against Vaccine Matched GenotypesDay 1 and Day 29
Percentage of Participants with Seroresponse Based on HBGA-blocking Antibody TiterDay 29
GMT of Binding Antibody (bAb) Against Vaccine-matched NoV GenotypesDay 1 and Day 29
VE of mRNA-1403 to Prevent First Occurrence of Protocol-defined Severe AGE Associated with Vaccine Matched GenotypesDay 15 through Day 730
VE of mRNA-1403 to Prevent First Occurrence of Protocol-defined Norovirus (NoV) AGE of Any Severity Associated with Vaccine Matched GenotypesDay 15 through Day 730
VE of mRNA-1403 to Prevent First Occurrence of Protocol-defined Moderate or Severe AGE Associated with Any Genogroup I or II NoV GenotypeDay 15 through Day 730
VE of mRNA-1403 to Prevent First Occurrence of Protocol-defined Severe AGE Associated with Any Genogroup I or II NoV GenotypeDay 15 through Day 730
VE of mRNA-1403 to Prevent Any Occurrence of Medically Attended AGE Associated with Vaccine Matched Genotypes, as well as any Genogroup I or II NoV GenotypeDay 15 through Day 730
VE of mRNA-1403 to Prevent Any Occurrence of AGE Hospitalizations Associated With Vaccine Matched Genotypes, as well as any Genogroup I or II NoV GenotypeDay 15 through Day 730
VE of mRNA-1403 to Prevent Any Occurrence of Protocol-defined Moderate or Severe AGE Associated with Vaccine Matched GenotypesDay 15 through Day 730
VE of mRNA-1403 to Prevent Any Occurrence of Protocol-defined AGE of Any Severity Associated with Any Genogroup I or II NoV GenotypeDay 15 through Day 730
Geometric Mean Titer (GMT) of Histo-blood Group Antigen (HBGA)-blocking Antibodies Titers Against Vaccine Matched GenotypesDay 1 and Day 29
GMFR of bAb TitersDay 1 and Day 29
Percentage of Participants with Seroresponse Based on bAb TiterDay 29

Trial Locations

Locations (271)

Centricity Research Mirabel

🇨🇦

Mirabel, Canada

Accel Research Sites - Achieve Clinical Research

🇺🇸

Birmingham, Alabama, United States

Cullman Clinical Trials

🇺🇸

Cullman, Alabama, United States

Alliance for Multispecialty Research, LLC

🇺🇸

Daphne, Alabama, United States

ClinMed, LLC

🇺🇸

Phoenix, Arizona, United States

DM Clinical - Phoenix

🇺🇸

Phoenix, Arizona, United States

HOPE Research Institute

🇺🇸

Phoenix, Arizona, United States

Abby's Research Institute

🇺🇸

Phoenix, Arizona, United States

Headlands Research Scottsdale

🇺🇸

Scottsdale, Arizona, United States

Scottsdale Clinical Trials

🇺🇸

Scottsdale, Arizona, United States

Hope Research Institute - Tempe

🇺🇸

Tempe, Arizona, United States

Arizona Liver Health

🇺🇸

Tucson, Arizona, United States

Quality of Life Medical and Research Center

🇺🇸

Tucson, Arizona, United States

Del Sol Research Management LLC.- Tucson

🇺🇸

Tucson, Arizona, United States

Lynn Institute of the Ozarks

🇺🇸

Little Rock, Arkansas, United States

Baptist Health Center for Clinical Research

🇺🇸

Little Rock, Arkansas, United States

ARK Clinical Research, LLC

🇺🇸

Fountain Valley, California, United States

ASCADA Research, LLC - Family Medicine

🇺🇸

Fullerton, California, United States

Matrix Clinical Research

🇺🇸

Los Angeles, California, United States

Velocity Clinical Research, San Diego

🇺🇸

La Mesa, California, United States

Ark Clinical Research

🇺🇸

Long Beach, California, United States

Velocity Clinical Research - Westlake

🇺🇸

Los Angeles, California, United States

Paradigm Research

🇺🇸

Redding, California, United States

Artemis Institute for Clinical Research

🇺🇸

San Diego, California, United States

Benchmark Research

🇺🇸

Fort Worth, Texas, United States

Peninsula Research Associates (PRA)

🇺🇸

Rolling Hills Estates, California, United States

Apex Clinical Research

🇺🇸

San Diego, California, United States

Lynn Institute of Denver

🇺🇸

Aurora, Colorado, United States

Tekton Research - Fort Collins

🇺🇸

Fort Collins, Colorado, United States

Tekton Research, Inc - Longmont Center

🇺🇸

Longmont, Colorado, United States

Imagine Research of Palm Beach County

🇺🇸

Boynton Beach, Florida, United States

Pioneer Clinical Studies

🇺🇸

Coral Gables, Florida, United States

Integrity Clinical Research, LLC (ICR SITES) - Doral

🇺🇸

Doral, Florida, United States

Alliance for multispecialty Research - Florida

🇺🇸

Doral, Florida, United States

AGA Clinical Trials

🇺🇸

Hialeah, Florida, United States

Best Quality Research Inc.

🇺🇸

Hialeah, Florida, United States

Neoclinical Research

🇺🇸

Hialeah, Florida, United States

Research Centers of America

🇺🇸

Hollywood, Florida, United States

Nature Coast Clinical Research, LLC - Inverness

🇺🇸

Inverness, Florida, United States

Westside Center for Clinical Research

🇺🇸

Jacksonville, Florida, United States

Clinical Neuroscience Solutions, Inc

🇺🇸

Orlando, Florida, United States

Health Awareness INC

🇺🇸

Jupiter, Florida, United States

University Clinical Research- Deland

🇺🇸

Lake Mary, Florida, United States

Meridien Research

🇺🇸

Lakeland, Florida, United States

Clinical Site Partners - Leesburg

🇺🇸

Leesburg, Florida, United States

Accel Clinical Research - Maitland

🇺🇸

Maitland, Florida, United States

Dade Research Center, LLC

🇺🇸

Miami, Florida, United States

Miami Clinical Research

🇺🇸

Miami, Florida, United States

Universal Axon Clinical Research

🇺🇸

Miami, Florida, United States

Florida International Research Center

🇺🇸

Miami, Florida, United States

Suncoast Research Associates, LLC

🇺🇸

Miami, Florida, United States

Miami Dade Medical Research Institute, LLC

🇺🇸

Miami, Florida, United States

Felicidad Medical Research

🇺🇸

Miami, Florida, United States

Aqualane Clinical Research

🇺🇸

Naples, Florida, United States

SUNCOAST Clinical Research

🇺🇸

New Port Richey, Florida, United States

Clinical Research Center of Florida

🇺🇸

Pompano Beach, Florida, United States

United Medical Research

🇺🇸

Port Orange, Florida, United States

Health Awareness, Inc

🇺🇸

Port Saint Lucie, Florida, United States

St. Johns Center for Clinical Research

🇺🇸

Saint Augustine, Florida, United States

IMA Clinical Research - St. Petersburg

🇺🇸

Saint Petersburg, Florida, United States

Global Clinical Professionals, LLC

🇺🇸

Saint Petersburg, Florida, United States

Precision Clinical Research, LLC

🇺🇸

Sunrise, Florida, United States

Albany Internal Medicine

🇺🇸

Albany, Georgia, United States

Delricht Research At Springer Wellness And Restorative Health

🇺🇸

Atlanta, Georgia, United States

Atlanta Center for Medical Research

🇺🇸

Atlanta, Georgia, United States

CenExel iResearch Atlanta, LLC

🇺🇸

Decatur, Georgia, United States

Javara Inc.

🇺🇸

Fayetteville, Georgia, United States

Fellows Research Alliance, Inc.

🇺🇸

Savannah, Georgia, United States

Velocity Clinical Research-Savannah

🇺🇸

Savannah, Georgia, United States

Clinical Research Atlanta/Headlands

🇺🇸

Stockbridge, Georgia, United States

Clinical Research Prime

🇺🇸

Idaho Falls, Idaho, United States

Velocity Clinical Research - Boise

🇺🇸

Meridian, Idaho, United States

IMA Clinical Research

🇺🇸

San Antonio, Texas, United States

Great Lakes Clinical Trials - Gurnee

🇺🇸

Gurnee, Illinois, United States

Bioluminix Clinical Research Chicago

🇺🇸

Naperville, Illinois, United States

Optimal Research

🇺🇸

Peoria, Illinois, United States

DM Clinical Research- River Forest

🇺🇸

River Forest, Illinois, United States

Velocity Clinical Research - Valparaiso

🇺🇸

Valparaiso, Indiana, United States

Velocity Clinical Research-Sioux City

🇺🇸

Sioux City, Iowa, United States

Johnson County Clin-Trials (JCCT)

🇺🇸

Lenexa, Kansas, United States

Velocity Clinical Research- Kansas City

🇺🇸

Overland Park, Kansas, United States

Tekton Research

🇺🇸

Wichita, Kansas, United States

AMR Lexington

🇺🇸

Lexington, Kentucky, United States

Velocity Clinical Research - Baton Rouge

🇺🇸

Baton Rouge, Louisiana, United States

Velocity Clinical Research - Covington

🇺🇸

Covington, Louisiana, United States

Clinical Trials Management, LLC

🇺🇸

Metairie, Louisiana, United States

Privia Medical Group

🇺🇸

Annapolis, Maryland, United States

Cenexel CBH (CBH Health)

🇺🇸

Gaithersburg, Maryland, United States

Velocity Clinical Research-Rockville

🇺🇸

Rockville, Maryland, United States

Javara Inc/Privia Medical Group, LLC

🇺🇸

Silver Spring, Maryland, United States

DM Clinical Research - Brookline

🇺🇸

Brookline, Massachusetts, United States

Skylight Health Research - Burlington

🇺🇸

Burlington, Massachusetts, United States

Headlands Research - Detroit

🇺🇸

Southfield, Michigan, United States

Great Lakes Research Institute

🇺🇸

Southfield, Michigan, United States

DM Clinical Research - Southfield

🇺🇸

Southfield, Michigan, United States

Oakland Medical Research Center

🇺🇸

Troy, Michigan, United States

Clinical Research Institute, Inc.

🇺🇸

Minneapolis, Minnesota, United States

Velocity Clinical Research, Gulfport

🇺🇸

Gulfport, Mississippi, United States

Clinical Research Professionals

🇺🇸

Chesterfield, Missouri, United States

Clinvest Headlands LLC

🇺🇸

Springfield, Missouri, United States

Delricht Research

🇺🇸

Springfield, Missouri, United States

Montana Medical Research, Inc

🇺🇸

Missoula, Montana, United States

Velocity Clinical Research-Lincoln

🇺🇸

Lincoln, Nebraska, United States

Velocity Clinical Research-Norfolk

🇺🇸

Norfolk, Nebraska, United States

Velocity Clinical Research-Omaha

🇺🇸

Omaha, Nebraska, United States

Javara Inc. / Nevada Health Centers, Ind

🇺🇸

Carson City, Nevada, United States

Vector Clinical Trials

🇺🇸

Las Vegas, Nevada, United States

Oasis Clinical Research

🇺🇸

Las Vegas, Nevada, United States

DM Clinical Research - New Jersey

🇺🇸

Jersey City, New Jersey, United States

IMA Clinical Research Warren

🇺🇸

Warren, New Jersey, United States

Albuquerque Clinical Trials (ACT)

🇺🇸

Albuquerque, New Mexico, United States

DM Clinical Research

🇺🇸

Tomball, Texas, United States

Velocity Clinical Research- Albuquerque

🇺🇸

Albuquerque, New Mexico, United States

Velocity Clinical Research - Binghamton

🇺🇸

Binghamton, New York, United States

DM Clinical - Brooklyn

🇺🇸

Brooklyn, New York, United States

Brooklyn Clinical Research

🇺🇸

Brooklyn, New York, United States

Velocity Clinical Research - Syracuse

🇺🇸

East Syracuse, New York, United States

Drug Trials America

🇺🇸

Hartsdale, New York, United States

Rochester Clinical Research, Inc

🇺🇸

Rochester, New York, United States

Velocity Clinical Research-Vestal

🇺🇸

Vestal, New York, United States

DelRicht Research, LLC

🇺🇸

Charlotte, North Carolina, United States

Javara Inc. - Tryon Medical-South Park

🇺🇸

Charlotte, North Carolina, United States

Velocity Clinical Research, Durham

🇺🇸

Durham, North Carolina, United States

West Clinical Research

🇺🇸

Morehead City, North Carolina, United States

Accellacare Raleigh

🇺🇸

Raleigh, North Carolina, United States

Accellacare of Wilmington

🇺🇸

Wilmington, North Carolina, United States

Javara - Wake Forest University Health Sciences

🇺🇸

Winston-Salem, North Carolina, United States

Velocity Clinical Research, Cleveland

🇺🇸

Beachwood, Ohio, United States

Velocity Clinical Research-Mt. Auburn

🇺🇸

Cincinnati, Ohio, United States

CTI Clinical Research Center

🇺🇸

Cincinnati, Ohio, United States

Velocity Clinical Reseach - Blue Ash

🇺🇸

Cincinnati, Ohio, United States

Velocity Clinical Research - Cincinnati OH

🇺🇸

Cincinnati, Ohio, United States

Centricity Research

🇺🇸

Columbus, Ohio, United States

Remington-Davis Clinical Research

🇺🇸

Columbus, Ohio, United States

Tekton Research, Inc - Edmond

🇺🇸

Edmond, Oklahoma, United States

Delricht Tate

🇺🇸

Tulsa, Oklahoma, United States

Tekton Research, Inc - Yukon Location

🇺🇸

Yukon, Oklahoma, United States

Altoona Center for Clinical Research - Research

🇺🇸

Duncansville, Pennsylvania, United States

Velocity Clinical Research - Providence

🇺🇸

East Greenwich, Rhode Island, United States

Velocity Clinical Research - Anderson

🇺🇸

Anderson, South Carolina, United States

DelRicht Research

🇺🇸

Charleston, South Carolina, United States

Coastal Carolina Research Center - North Charleston

🇺🇸

North Charleston, South Carolina, United States

Velocity Clinical Research, Spartanburg

🇺🇸

Spartanburg, South Carolina, United States

PMG Research of Bristol, LLC

🇺🇸

Bristol, Tennessee, United States

Delricht Moyer

🇺🇸

Hendersonville, Tennessee, United States

CNS Healthcare DBA Clinical Neuroscience Solutions, INC

🇺🇸

Memphis, Tennessee, United States

IMA Clinical Research Austin

🇺🇸

Austin, Texas, United States

Tekton Research, Inc. - Beaumont

🇺🇸

Beaumont, Texas, United States

Headlands Research Brownsville

🇺🇸

Brownsville, Texas, United States

Family Medicine Associates of Texas

🇺🇸

Carrollton, Texas, United States

Javara Inc (Conroe)

🇺🇸

Conroe, Texas, United States

WR-Global Medical Research, LLC

🇺🇸

Dallas, Texas, United States

El Paso Research

🇺🇸

El Paso, Texas, United States

West Houston Clinical Research Service

🇺🇸

Houston, Texas, United States

DM Clinical Research - CyFair

🇺🇸

Houston, Texas, United States

DM Clinical Research - Bellaire

🇺🇸

Houston, Texas, United States

DM Clinical Research - Irving

🇺🇸

Irving, Texas, United States

ACRC Trials

🇺🇸

Plano, Texas, United States

Research Your Health

🇺🇸

Plano, Texas, United States

Delricht Research At Zomnir Family Medicine

🇺🇸

Prosper, Texas, United States

DM Clinical Research - San Antonio

🇺🇸

San Antonio, Texas, United States

Tekton Research Inc - San Antonio

🇺🇸

San Antonio, Texas, United States

DM Clinical Research - Sugarland

🇺🇸

Sugar Land, Texas, United States

DM Clinical Research - Tomball

🇺🇸

Tomball, Texas, United States

Cope Family Medicine

🇺🇸

Bountiful, Utah, United States

JBR Clinical Research

🇺🇸

Salt Lake City, Utah, United States

Charlottesville Medical Research Center, LLC

🇺🇸

Charlottesville, Virginia, United States

Velocity Clinical Research - Hampton

🇺🇸

Hampton, Virginia, United States

Health Research of Hampton Roads

🇺🇸

Newport News, Virginia, United States

AMR Norfolk

🇺🇸

Norfolk, Virginia, United States

Velocity Clinical Research-Portsmouth

🇺🇸

Portsmouth, Virginia, United States

Clinical Research Partners, LLC

🇺🇸

Richmond, Virginia, United States

DM Clinical Research - Seattle

🇺🇸

Seattle, Washington, United States

Frontier Clinical Research, LLC

🇺🇸

Kingwood, West Virginia, United States

Paratus Clinical Research Canberra

🇦🇺

Bruce, Australian Capital Territory, Australia

Northside Health

🇦🇺

Coffs Harbour, New South Wales, Australia

Momentum Clinical Research Darlinghurst

🇦🇺

Darlinghurst, New South Wales, Australia

Paratus Clinical Research Central Coast

🇦🇺

Kanwal, New South Wales, Australia

Paratus Clinical Research Brisbane

🇦🇺

Herston, Queensland, Australia

Griffith University Hospital

🇦🇺

Southport, Queensland, Australia

Fusion Clinical Research

🇦🇺

Norwood, South Australia, Australia

Veritus Research

🇦🇺

Bayswater, Victoria, Australia

Emeritus Research (Melbourne)

🇦🇺

Camberwell, Victoria, Australia

The Peter Doherty Institute for Infection & Immunity

🇦🇺

North Melbourne, Victoria, Australia

CARe Clinic

🇨🇦

Calgary, Canada

Intermed Groupe Sante

🇨🇦

Chicoutimi, Canada

Apex Trials

🇨🇦

Guelph, Canada

Isaak Walton Killam Health Centre

🇨🇦

Halifax, Canada

Okanagan Clinical Trials

🇨🇦

Kelowna, Canada

Centricity Research Quebec City

🇨🇦

Levis, Canada

Milestone Research Inc.

🇨🇦

London, Canada

Centricity Research Pointe-Claire

🇨🇦

Pointe-Claire, Canada

Centre de Recherche Saint-Louis

🇨🇦

Quebec, Canada

Clinique Spécialisée en Allergie de la Capitale

🇨🇦

Québec, Canada

CARe Clinic Red Deer

🇨🇦

Red Deer, Canada

Richmond Clinical Trials

🇨🇦

Richmond, Canada

Bluewater Clinical Research Group, Inc

🇨🇦

Sarnia, Canada

Diex Research Sherbrooke Inc

🇨🇦

Sherbrooke, Canada

Medicor Research Inc.

🇨🇦

Sudbury, Canada

Centricity Research Toronto LMC

🇨🇦

Toronto, Canada

Diex Recherche Trois-Rivières

🇨🇦

Trois-Rivieres, Canada

Colchester Research Group

🇨🇦

Truro, Canada

Chubu Rosai Hospital - Rheumatology & Collageous

🇯🇵

Nagoya, Aichi, Japan

Daido clinic

🇯🇵

Nagoya, Aichi, Japan

Medical Corporation JR Hiroshima Hospital

🇯🇵

Hiroshima-shi, Hirosima [Hiroshima], Japan

Kotoni Medical Support Clinic

🇯🇵

Sapporo, Hokkaidô [Hokkaido], Japan

Tenjin Sogo Clinic

🇯🇵

Fukuoka-shi, Hukuoka [Fukuoka], Japan

Matsuba Clinic

🇯🇵

Kawasaki-shi, Kanagawa, Japan

Hayashi-Katagihara Clinic

🇯🇵

Kyoto-shi, Kyôto [Kyoto], Japan

Yokoi Medicine Clinic

🇯🇵

Minoh, Osaka, Japan

Asano Clinic

🇯🇵

Kawagoe-shi, Saitama, Japan

Omi Medical Center

🇯🇵

Yabasecho, Shiga, Japan

Dojinkinenkai Meiwa Hospital

🇯🇵

Chiyoda-ku, Tôkyô [Tokyo], Japan

Nihonbashi Sakura Clinic

🇯🇵

Chuo-ku, Tôkyô [Tokyo], Japan

Medical Corporation Asbo Tokyo Asbo Clinic

🇯🇵

Minato-Ku, Tôkyô [Tokyo], Japan

Tokyo Saiseikai Central Hospital

🇯🇵

Minato-Ku, Tôkyô [Tokyo], Japan

Denenchofu Family Clinic

🇯🇵

Ota, Tôkyô [Tokyo], Japan

Higashi-Shinjuku Clinic - Internal Medicine

🇯🇵

Shinjuku-ku, Tôkyô [Tokyo], Japan

Shimamura Memorial Hospital

🇯🇵

Suginami, Tôkyô [Tokyo], Japan

P-one Clinic

🇯🇵

Hachioji, Tôkyô, Japan

Sasaki Clinic

🇯🇵

Hyogo, Japan

NewHeart Watanabe Institute

🇯🇵

Kanazawa-shi, Japan

Izumino Hospital

🇯🇵

Kochi, Japan

Sapporo Odori Endoscopy Clinic

🇯🇵

Sapporo-shi, Japan

Takatsuki General Hosiptal

🇯🇵

Takatsuki-shi, Japan

CEVAXIN David

🇵🇦

David, Chiriquí, Panama

CEVAXIN Avenida Mexico

🇵🇦

Ciudad de Panamá, Panama

CEVAXIN Chorrera

🇵🇦

La Chorrera, Panama

CEVAXIN 24 de Diciembre

🇵🇦

Panama City, Panama

BRCR Global

🇵🇷

Ponce, Puerto Rico

Clinical Research Puerto Rico, Inc.

🇵🇷

San Juan, Puerto Rico

Research Works San Juan

🇵🇷

San Juan, Puerto Rico

Velocity Clinical Research - High Wycombe

🇬🇧

High Wycombe, Buckinghamshire, United Kingdom

Warrington and Halton Teaching Hospitals NHS Foundation Trust - Halton General Hospital

🇬🇧

Runcorn, Cheshire, United Kingdom

Royal Cornwall Hospitals NHS Trust - Royal Cornwall Hospital

🇬🇧

Truro, Cornwall, United Kingdom

St George's University Hospitals NHS Foundation Trust - St George's Hospital

🇬🇧

London, England, United Kingdom

Accellacare South London

🇬🇧

Orpington, Kent, United Kingdom

Layton Medical Centre

🇬🇧

Blackpool, Lancashire, United Kingdom

Panthera Biopartners - Manchester

🇬🇧

Rochdale, Manchester, United Kingdom

Northern Care Alliance NHS Foundation Trust - Salford Royal Hospital

🇬🇧

Salford, Manchester, United Kingdom

Lakeside Healthcare

🇬🇧

Corby, Northamptonshire, United Kingdom

Eynsham Medical Center

🇬🇧

Witney, Oxfordshire, United Kingdom

NHS Grampian - Aberdeen Royal Infirmary

🇬🇧

Aberdeen, United Kingdom

NIHR Welcome Trust Clinical Research Facility

🇬🇧

Birmingham, United Kingdom

Bournemouth Research Hub

🇬🇧

Bournemouth, United Kingdom

North Bristol NHS Trust - Southmead Hospital

🇬🇧

Bristol, United Kingdom

Cardiff and Vale University Health Board - University Hospital Wales

🇬🇧

Cardiff, United Kingdom

Accellacare Warwickshire Quality Research Site

🇬🇧

Coventry, United Kingdom

NHS Lothian - Western General Hospital

🇬🇧

Edinburgh, United Kingdom

Panthera Biopartners - North London

🇬🇧

Enfield Town, United Kingdom

Royal Devon & Exeter Hospital (Wonford)

🇬🇧

Exeter, United Kingdom

CPS Research by FutureMeds

🇬🇧

Glasgow, United Kingdom

Glasgow Clinical Research Facility

🇬🇧

Glasgow, United Kingdom

Panthera Biopartners - Glasgow

🇬🇧

Glasgow, United Kingdom

University Hospitals of Leicester NHS Trust

🇬🇧

Leicester, United Kingdom

FutureMeds Wirral

🇬🇧

Liverpool, United Kingdom

Mile End Hospital

🇬🇧

London, United Kingdom

Royal Free London NHS Foundation Trust - Royal Free Hospital

🇬🇧

London, United Kingdom

Manchester University NHS Foundation Trust

🇬🇧

Manchester, United Kingdom

FutureMeds Newcastle

🇬🇧

Newcastle upon Tyne, United Kingdom

The Newcastle Upon Tyne Hospitals NHS Foundation Trust

🇬🇧

Newcastle upon Tyne, United Kingdom

Leeds Teaching Hospitals NHS Trust - St James' University Hospital

🇬🇧

Nottingham, United Kingdom

Plymouth Hospital NHS trust-Derriford Hospital

🇬🇧

Plymouth, United Kingdom

Portsmouth Research Hub

🇬🇧

Portsmouth, United Kingdom

Panthera Biopartners - Sheffield

🇬🇧

Sheffield, United Kingdom

Accellacare Yorkshire Quality Research Site

🇬🇧

Shipley, United Kingdom

Wansford Research Ltd

🇬🇧

Wansford, United Kingdom

Weymouth Research Hub

🇬🇧

Weymouth, United Kingdom

Windrush Medical Practice

🇬🇧

Witney, United Kingdom

North Wales Clinical Research Centre (NWCRC)

🇬🇧

Wrexham, United Kingdom

Panthera Biopartners - York

🇬🇧

York, United Kingdom

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