Effect of Platelet Rich Plasma on Outcome of Narrow Band UVB in Treatment of Vitiligo; Clinical and Histopathological Study

Not Applicable

Active, not recruiting

• Conditions: Management of Stable Vitiligo
• Interventions: Procedure: platelet rich plasma, narrow band UVB

• Registration Number: NCT06370650
• Lead Sponsor: Sohag University

Brief Summary

For each patient, one side of body will be treated with NB-UVB alone while the other side will be treated with NB-UVB therapy in addition to intradermal injection of PRP every 2 weeks. Patients will be photographed at the first visit, in the middle and at the end of therapy. Each patient will sign a written consent form to be included in the study and to be photographed.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-12-08
• Primary Completion: 2024-01-25
• Status Verified: 2024-04
• Study First Submitted: 2024-04-13
• Study First Submitted QC: 2024-04-13
• Last Update Submitted: 2024-04-13
• Study First Posted: 2024-04-17
• Last Update Posted: 2024-04-17
• Study Completion: 2024-06-30

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Patients with stable non segmental vitiligo. (Absence of koebnerization, absence of new lesion and absence of widening of the existing lesions).

Patients have more than 15 years.

Exclusion Criteria

Patients have active vitiligo (appearance of new lesion, history of koebnerization).

Pregnant and lactating women. History of keloid formation. Anemia (hemoglobin level <10gm/dl), thrombocytopenia (platelet count <100,000 /µL), coagulopathies or patients on anticoagulant therapy and patients with iron deficiency.

Patients taking drugs that prolong bleeding time such as Aspirin and vitamin E Patients taking treatment of vitiligo in last 2 months

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Narrow band UVB	platelet rich plasma, narrow band UVB	-
Platelet rich plasma plus narrow band UVB	platelet rich plasma, narrow band UVB	-

Primary Outcome Measures

Name	Time	Method
Improvement of vitiligo	within 6 months	increase repigmentation score

Trial Locations

Locations (1)

Faculty of Medicine, Sohag University; 🇪🇬 Sohag, Egypt