Comparison of efficacy of palonosetron - dexamethasone combination with palonosetron or dexamethasone alone for prophylaxis against post operative nausea and vomiting in patients undergoing middle ear surgery

Department Of Anesthesiology And Critical Care0 个研究点目标入组 0 人开始时间: 待定最近更新: 2021年11月24日

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•Patients Belonging To American Society Of Anaesthesiology(ASA) Grade 1 And 2 , And Of Age Group 18 TO 60 Years With Body Weight 40 TO 80 Kg Of Either Sex Undergoing Middle Ear Surgery And Willing To Give A Written And Informed Consent.

•1 Pregnant and lactating females or patients having huge abdominal mass or tumour.
•2 A cancer patient who has had chemotherapy within 4 weeks prior to study entry (Screening visit) or any kind of emetogenic radiotherapy within 8 weeks prior to study entry (Screening visit).
•3 Patients who had received any investigational drugs within 30 days before study entry or taken any drug with potential antiemetic efficacy within 24 hours prior to anaesthetic procedures.
•4 Patients who have history of any vomiting, retching, or nausea in the 24 hours preceding the administration of anaesthesia.
•5 Patients who have current history of alcohol abuse or drug abuse or taking any hormonal supplements.
•6 Patients having hypersensitivity/contraindication to 5-HT3 antagonists or study drug.
•7 Patients having cardio respiratory dysfunction or renal, hepatic or metabolic derangements or history of epilepsy.
•8 Patients with Ryleâ??s tubes in situ.
•9 Patients in varying degrees of shock during pre and post operative period.
•10 Patients who will require any opioid analgesic for post operative pain relief during the period of study.

发起方

Department Of Anesthesiology And Critical Care