Telomeres Parameters in Cirrhosis

• Conditions: Cirrhosis

• Registration Number: NCT02131831
• Lead Sponsor: Meir Medical Center

Brief Summary

There are several factors that influence telomere length in patients with cirrhosis, such as metabolic derangements and infectious etiologies, The aim of the study is to compare telomere length and other parameters related to genetic instability in telomere/ telomerase system, in peripheral blood lymphocytes in cirrhosis from different etiologies.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2014-04-26
• Study First Submitted QC: 2014-05-04
• Study First Posted: 2014-05-06
• Study Start: 2014-06
• Status Verified: 2014-09
• Last Update Submitted: 2014-09-15
• Last Update Posted: 2014-09-16
• Primary Completion: 2015-12
• Study Completion: 2015-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• cirrhotic patients from different etiologies

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Exclusion Criteria

• decompensated cirrhosis (Child C)
• age under 18 years
• any known malignancy, including hepatocellular carcinoma
• patient that are unable to sign for informed consent

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
telomerase activity	baseline	number of copies of telomerase in peripheral blood lymphocytes, as determined by FISH

Trial Locations

Locations (1)

Meir Medical Center; 🇮🇱 Kfar Saba, Israel