The Effect of Lateral Tilt on Ventilation Distribution in Lungs Assessed by Electrical Impedance Tomography: A Pilot Prospective Randomized Study in Neurocritical Care
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 250
- 试验地点
- 2
- 主要终点
- Atelectasis/collapse
研究概览
简要总结
Prevention of lung inhomogeneity is an essential part of preventive strategy in neurocritical care, reducing the risks of secondary brain damage from hypoxemia, hypo/hypercapnia or pneumonia.
详细描述
In the monocentric, intervention, prospective, randomized study, the investigators will examine the effect of lateral tilting (routinely used in critical care) on the lung inhomogeneity that will be analyzed by electrical impedance tomography (EIT) in the unconscious patients with acute primary brain disease and artificial pulmonary ventilation. Two types of lateral tilting will be compared: manual positioning of body by nurse versus the bed tilting (15° lateral tilt, original company (LINET) and product brand name (Eleganza 5).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Investigator)
盲法说明
Research Randomizer
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Primary brain disease
- •Hospitalization in Neurocenter, Neurointensive Care Unit
- •Age>18 years
- •Unconsciousness
- •Artificial pulmonary ventilation
排除标准
- •Intracranial hypertension
- •History of primary lung disease
- •The terminal stage of the disease
- •Refractory hemodynamic instability
结局指标
主要结局
Atelectasis/collapse
时间窗: up to 24 weeks
Assessed by electrical impedance tomography (EIT) or chest x-ray (CXR) at end of observation period
次要结局
- Evaluating hemodynamic parameters(up to 24 weeks)
- Comparing duration of stay in Neurocenter Neurointensive Care Unit(up to 24 weeks)
- Profiling pneumonia incidence(up to 24 weeks)
- Evaluating oxygenation parameters(up to 24 weeks)
- Cost effectiveness measurement between two groups(up to 24 weeks)
研究者
Vera Spatenkova, MD, Ph.D.
Head of Neurocenter
Regional Hospital Liberec