Accuracy of the calcium-creatinine ratio in spot urine sample in prediction of preeclampsia
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 246
研究概览
简要总结
Research question: Accuracy of the calcium-creatinine ratio (CCR) in a spot urine sample for the prediction of preeclampsia (PE). Background: Currently, there is no reliable diagnostic test to predict preeclampsia. Participants: Two hundred and forty-six pregnant women, attending the ante-natal clinic after 20 weeks` gestation were included in this study. After exclusion of pre-existing chronic renal disease affecting calcium and/or creatinine excretion, spot urine samples were taken from participants to detect the calcium-creatinine ratio. Results: The calcium-creatinine ratio = 0.04 had 79.3% sensitivity, 96.3% specificity, 91.5% positive predictive value (PPV), 90.3% negative predictive value (NPV), and 90.7% overall accuracy in prediction of preeclampsia. Limitation: Women who refused to participate and/or give consent was the only limitation faced during this study.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 20 Years 至 40 Years（—）
- 性别
- Female
入选标准
- •The study will include women between 20-40 years old, attending the ante-natal clinic of for ante-natal care during the period from May 2018 till May 2020 after informed consent, and approval of the Obstetrics department .
- •Women <20 years, >40 years age, refused to participate in the study and/or refused to give consent will excluded from the study.
- •A complete obstetrical history, clinical examination, the necessary investigations will be done to exclude other conditions affecting urinary calcium/creatinine ratio.
- •As part of the routine follow-up in the ante-natal clinics, the urine sample taken from the pregnant women for urine albumin assessment, will be used for the assessment of the calcium-creatinine ratio after informed consent. Follow–up of the studied women till delivery; women who will develop preeclampsia will constitute the study group, and other normotensive women without preeclampsia will constitute the controls.
排除标准
- •Women <20 years, >40 years age, refused to participate in the study and/or refused to give consent will excluded from the study.