The Effect of Huel on Markers of Inflammation

Not Applicable

Active, not recruiting

• Conditions: 4 Weeks Supplementation of Huel Ready to Eat Foods

• Registration Number: NCT07049874
• Lead Sponsor: Newcastle University

Brief Summary

This project will assess the effect of Huel on markers of gastrointestinal inflammation of 30 generally healthy individuals. The aim is to identify any changes in the markers of inflammation status of volunteers in any of the 9 markers to be monitored. Inflammation status will be measured at the start of the study, after one week of their habitual diets and again after four weeks of consuming two ready to drink Huel products per day, one Hot \& Savoury Huel (grain-based option only) and the remainder of their calorie intake to be made up of Huel Powder (v3.1).

Detailed Description

Not available

Study Timeline

• Study Start: 2025-02-01
• Status Verified: 2025-06
• Study First Submitted: 2025-06-25
• Study First Submitted QC: 2025-06-25
• Last Update Submitted: 2025-06-25
• Study First Posted: 2025-07-03
• Last Update Posted: 2025-07-03
• Primary Completion: 2025-08-01
• Study Completion: 2025-08-01

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Generally healthy Aged 18 years and over Non-pregnant, Non-lactating non-smoking

Exclusion Criteria

Smoker Pregnant Lactating BMI >30 Food allergy Disordered eating Disorder which could impact the study outcomes Medications which could impact the study outcomes

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
C-Reactive protein	baseline and after 4 weeks supplementation
neutrophils	baseline and after 4 weeks supplementation
TNF-alpha	baseline and after 4 weeks supplementation
IL-10	baseline and after 4 weeks supplementation
IL-6	baseline and after 4 weeks supplementation

Secondary Outcome Measures

Name	Time	Method
arachidonic acid	baseline and after 4 weeks supplementation
linoleic acid	baseline and after 4 weeks supplementation
Body mass	baseline and after 4 weeks supplementation
Waist cercumference	baseline and after 4 weeks supplementation
alpha-linoleic acid	baseline and after 4 weeks supplementation
eicosapentaenoic acid	baseline and after 4 weeks supplementation
Body Mass Index	baseline and after 4 weeks supplementation

Trial Locations

Locations (1)

Faculty of Medical Sciences; 🇬🇧 Newcastle Upon Tyne, Tyne and wear, United Kingdom