EXPRESON-IN : Intracerebral Recordings of P3a Responses to Expressive Own-names

Not Applicable

• Conditions: Intractable Epilepsy
• Interventions: Other: Evoked related potentials

• Registration Number: NCT04810832
• Lead Sponsor: Centre Hospitalier St Anne

Brief Summary

Neurophysiologic evaluation of disorders of consciousness (DOC) patients in intensive care unit include late auditory evoked potentials. It allows the physicians to record cerebral responses of patients to auditory stimuli and in particularly to their own name (as the P3a response). Numerous studies try to improve the relevance of the auditory stimuli used in this paradigm and notably using more expressive stimuli.

Here the investigators investigate the intracerebral correlates of the P3a responses recorded on the scalp with neutral and more expressive stimuli.

Detailed Description

Late auditory evoked potentials (as P3 wave) are used in neurophysiology to assess the level of consciousness in DOC (disorder of consciousness) patients. The P3 wave, elicited by listening standard and deviant stimuli, corresponds to the activation of a frontoparietal network and is considered to reflect a cognitive attention task. Using the own name of the patient as deviant stimuli improve the ability to detect the P3 wave because of the particularly relevance of this stimulus for the patient.

In human cognition, to identify the expressivity valence of a voice is essential. Neural processing of expressive voices should involves more widespread brain areas than neutral voices processing.

Here the investigators investigate the intracerebral correlates of the P3a responses recorded on the scalp to own-name stimuli uttered by neutral and more expressive voices (positive : smiling voice or negative : rough voice) in adult pharmacoresistant epilepsy patients.

Study Timeline

• Study Start: 2020-09-09
• Status Verified: 2021-01
• Study First Submitted: 2021-03-18
• Study First Submitted QC: 2021-03-19
• Study First Posted: 2021-03-23
• Last Update Submitted: 2021-07-06
• Last Update Posted: 2021-07-09
• Primary Completion: 2022-09-09
• Study Completion: 2023-09-09

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Intractable focal epilepsy with undergoing pre-surgical evaluation
• intracerebral electrodes implantation in auditory cortices, temporal lobe, superior temporal gyrus, limbic areas, frontal lobe
• Given Consent to inclusion

Exclusion Criteria

• Deafness
• Pregnancy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SEQUENTIAL

Arm && Interventions

Group	Intervention	Description
Whole group	Evoked related potentials	The whole group undergo the two phases of the study: * 1/ They listen successively the 3 oddball paradigms in the department of neurophysiology : P3 own-name recorded by listening to a smiling voice P3 own-name recorded by listening to a neutral voice P3 own-name recorded by listening to a rough voice * 2/ They listen successively the same 3 oddball paradigms in the neurosurgical department, during their intractable epilepsy presurgical evaluation : P3 own-name recorded by listening to a smiling voice P3 own-name recorded by listening to a neutral voice P3 own-name recorded by listening to a rough voice

Primary Outcome Measures

Name	Time	Method
Latencies cartography of intracranial responses to own-name uttered by neutral voice	1 year	Analyse of latencies of intracranial responses recorded to own-name uttered by neutral voice to build a map of the brain process of this responses
Latencies cartography of intracranial responses to own-name uttered by expressive voices	1 year	Analyse of latencies of intracranial responses recorded to own-name uttered by expressive voices to build a map of the brain process of this responses

Secondary Outcome Measures

Name	Time	Method
Comparison between brain responses to own-name uttered by expressive voices recorded with intracerebral electrodes versus scalp electrodes	1 year	Qualitative comparison between scalp and intracranial recordings with the expressive voices paradigms (comparison of the latencies of the recorded responses)
Comparison between brain responses to own-name uttered by neutral voices recorded with intracerebral electrodes versus scalp electrodes	1 year	Qualitative comparison between scalp and intracranial recordings with the neutral voices paradigms (comparison of the latencies of the recorded responses)

Trial Locations

Locations (1)

GHU Paris - Sainte Anne; 🇫🇷 Paris, France