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Active Matrix Metalloproteinase-8 (aMMP-8) Chair-side Test in Different Periodontal Disease

Completed
Conditions
Periodontal Diseases
Registration Number
NCT03527901
Lead Sponsor
Aydin Adnan Menderes University
Brief Summary

The aim of this study to evaluate the diagnostic accuracy of a new qualitative aMMP-8 POC test in different periodontal health and disease and as compared to the established quantitative laboratory method (ELISA)

Detailed Description

MMP-8 has been reported to reflect the inflammatory status in periodontal tissues and, therefore represent as potential biomarkers of periodontitis. A positive aMMP-8 test could be an early indicator of these excessive and undesired tissue reactions.

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
103
Inclusion Criteria
  • Systemically healthy
  • Nonsmokers
Exclusion Criteria
  • Participants were not included if they had systemic disease such as diabetes, cardiovascular.
  • Participants who took regular medications that could affect of periodontal tissue
  • Participants who received antibiotics less than 10 weeks before the study

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
aMMP-8 levels of GCF2 hours

GCF levels measured by IFMA

Secondary Outcome Measures
NameTimeMethod
Salivary MMP-8 levels2 hours

Saliva levels measured by IFMA

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