Active Matrix Metalloproteinase-8 (aMMP-8) Chair-side Test in Different Periodontal Disease

Completed

• Conditions: Periodontal Diseases

• Registration Number: NCT03527901
• Lead Sponsor: Aydin Adnan Menderes University

Brief Summary

The aim of this study to evaluate the diagnostic accuracy of a new qualitative aMMP-8 POC test in different periodontal health and disease and as compared to the established quantitative laboratory method (ELISA)

Detailed Description

MMP-8 has been reported to reflect the inflammatory status in periodontal tissues and, therefore represent as potential biomarkers of periodontitis. A positive aMMP-8 test could be an early indicator of these excessive and undesired tissue reactions.

Study Timeline

• Study Start: 2015-03-01
• Primary Completion: 2016-03-01
• Status Verified: 2016-05
• Study Completion: 2016-06-01
• Study First Submitted: 2018-05-05
• Study First Submitted QC: 2018-05-16
• Last Update Submitted: 2018-05-16
• Study First Posted: 2018-05-17
• Last Update Posted: 2018-05-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 103

Inclusion Criteria

• Systemically healthy
• Nonsmokers

Exclusion Criteria

• Participants were not included if they had systemic disease such as diabetes, cardiovascular.
• Participants who took regular medications that could affect of periodontal tissue
• Participants who received antibiotics less than 10 weeks before the study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
aMMP-8 levels of GCF	2 hours	GCF levels measured by IFMA

Secondary Outcome Measures

Name	Time	Method
Salivary MMP-8 levels	2 hours	Saliva levels measured by IFMA