The clinical effect of oral vitamin D2 supplementation on psoriasis: A double-blind, randomized, placebo-controlled study

Phase 2

Completed

• Conditions: Oral vitamin D2, Psoriasis, Vitamin D deficiency; The purpose of this study is to investigate the clinical effect of oral vitamin D supplement in patients with psoriasis.; Vitamin D&#44

• Registration Number: TCTR20180613001
• Lead Sponsor: Thammasat University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2017-10-31
• Study Start: 2018-06-13
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 46

Inclusion Criteria

Patients with chronic stable plaque type psoriasis, aged 18-70 years (both men and women), mild psoriasis evaluated by using Psoriasis Area and Severity Index (PASI) score (PASI < 10), and no change of the psoriatic medication during study period

Exclusion Criteria

Currently on systemic therapy or phototherapy or last episodes within 30 days before enrollment, hepatic impairment, renal impairment, cancer, receiving immunosuppressive medication or chemotherapy, receiving vitamin D, calcium supplement, bisphosphonate, antiepileptic agents, anticoagulants, history of hypercalcemia, nephrolithiasis, parathyroid disease, pregnancy, and breastfeeding woman

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The improvement of Psoriasis Area and Severity Index (PASI) at 3- and 6-months after treatment 0-, 3- and 6-months after treatment Psoriasis Area and Severity Index (PASI)

Secondary Outcome Measures

Name	Time	Method
Prevalence of vitamin D deficiency and insufficiency in psoriasis 0-, 3- and 6-months after treatment Prevalence,The improvement of vitamin D deficiency and insufficiency at 3- and 6-months after treatment 0-, 3- and 6-months after treatment serum 25(OH) vitamin D level,Change of serum 25(OH) vitamin D level 0-, 3- and 6-months after treatment Serum 25(OH) vitamin D level,Change of calcium, phosphate, parathyroid hormone, C-reactive protein (CRP) during the study period 0-, 3- and 6-months after treatment Serum calcium, phosphate, parathyroid hormone, C-reactive protein (CRP)