Influence of Stellate Ganglion Block on Tourniquet Response in Lower Limbs.
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- heart rate
研究概览
简要总结
To investigate the influence of stellate ganglion block on tourniquet response during surgery in patients undergoing elective lower limb Department of orthopedics.
详细描述
Select elective general anesthesia in 100 cases of lower extremity Department of orthopedics surgery patients were randomly divided into SGB group and control group, SGB group received anesthesia before the right stellate ganglion block intervention, the control group underwent right deltoid muscle injection, changes in hemodynamics in two groups were recorded in heart rate, blood pressure, and before anesthesia, after intubation 3min 1H, a tourniquet, tourniquet release before and after tourniquet release 3min, 30min, changes in blood physiological analysis. The effect of stellate ganglion block on tourniquet response during perioperative period was observed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •American Society of anesthesiologists Grade 1-3 Patients
- •undergoing lower limb surgery under general anesthesia
- •should be treated with tourniquet
排除标准
- •Tourniquet application time is less than 1h, greater than 1.5h
- •Abnormal coagulation function
- •perioperative application of hormone
- •lidocaine allergy
- •can not cope with nerve block
- •nerve block failure
- •minimally invasive surgery
结局指标
主要结局
heart rate
时间窗: 2 hours in perioperative period
bpm
ET-1
时间窗: One minute after the radial artery puncture, one minute after intubation, tourniquet application 1 hour, one minute before tourniquet, loose after a tourniquet for 3 minutes, 30 minutes after a tourniquet
ELISA ng/L
SOD
时间窗: One minute after the radial artery puncture, one minute after intubation, tourniquet application 1 hour, one minute before tourniquet, loose after a tourniquet for 3 minutes, 30 minutes after a tourniquet
ELISA μg/L
IL-6
时间窗: One minute after the radial artery puncture, one minute after intubation, tourniquet application 1 hour, one minute before tourniquet, loose after a tourniquet for 3 minutes, 30 minutes after a tourniquet
ELISA pg/ml
cTn-T
时间窗: One minute after the radial artery puncture, one minute after intubation, tourniquet application 1 hour, one minute before tourniquet, loose after a tourniquet for 3 minutes, 30 minutes after a tourniquet
ELISA μg/L
blood pressure
时间窗: 2 hours in perioperative period
mmHg
Lac
时间窗: One minute after the radial artery puncture, the tourniquet was applied for 1 hours and the tourniquet was released 3 minutes after the tourniquet release 30 minutes
blood gas analysis mmol/L
norepinephrine
时间窗: One minute after the radial artery puncture, one minute after intubation, tourniquet application 1 hour, one minute before tourniquet, loose after a tourniquet for 3 minutes, 30 minutes after a tourniquet
ELISA nmol/L
cortisol
时间窗: One minute after the radial artery puncture, one minute after intubation, tourniquet application 1 hour, one minute before tourniquet, loose after a tourniquet for 3 minutes, 30 minutes after a tourniquet
ELISA ng/ml
postoperative pain
时间窗: hour 1、hour 6、hour 24、hour 48 after operation
VAS score
MDA
时间窗: One minute after the radial artery puncture, one minute after intubation, tourniquet application 1 hour, one minute before tourniquet, loose after a tourniquet for 3 minutes, 30 minutes after a tourniquet
ELISA nmol/ml
次要结局
- Complication of puncture(2 hours in perioperative period)