Influence of Stellate Ganglion Block on Tourniquet Response in Lower Limbs.
Trial Snapshot
- Phase
- Not Applicable
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- heart rate
Study Overview
Brief Summary
To investigate the influence of stellate ganglion block on tourniquet response during surgery in patients undergoing elective lower limb Department of orthopedics.
Detailed Description
Select elective general anesthesia in 100 cases of lower extremity Department of orthopedics surgery patients were randomly divided into SGB group and control group, SGB group received anesthesia before the right stellate ganglion block intervention, the control group underwent right deltoid muscle injection, changes in hemodynamics in two groups were recorded in heart rate, blood pressure, and before anesthesia, after intubation 3min 1H, a tourniquet, tourniquet release before and after tourniquet release 3min, 30min, changes in blood physiological analysis. The effect of stellate ganglion block on tourniquet response during perioperative period was observed.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 75 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •American Society of anesthesiologists Grade 1-3 Patients
- •undergoing lower limb surgery under general anesthesia
- •should be treated with tourniquet
Exclusion Criteria
- •Tourniquet application time is less than 1h, greater than 1.5h
- •Abnormal coagulation function
- •perioperative application of hormone
- •lidocaine allergy
- •can not cope with nerve block
- •nerve block failure
- •minimally invasive surgery
Arms & Interventions
Stellate ganglion block
Stellate ganglion block
Intervention: Stellate ganglion block (Procedure)
control group
Deltoid muscle injection
Intervention: control group (Procedure)
Outcomes
Primary Outcomes
heart rate
Time Frame: 2 hours in perioperative period
bpm
ET-1
Time Frame: One minute after the radial artery puncture, one minute after intubation, tourniquet application 1 hour, one minute before tourniquet, loose after a tourniquet for 3 minutes, 30 minutes after a tourniquet
ELISA ng/L
SOD
Time Frame: One minute after the radial artery puncture, one minute after intubation, tourniquet application 1 hour, one minute before tourniquet, loose after a tourniquet for 3 minutes, 30 minutes after a tourniquet
ELISA μg/L
IL-6
Time Frame: One minute after the radial artery puncture, one minute after intubation, tourniquet application 1 hour, one minute before tourniquet, loose after a tourniquet for 3 minutes, 30 minutes after a tourniquet
ELISA pg/ml
cTn-T
Time Frame: One minute after the radial artery puncture, one minute after intubation, tourniquet application 1 hour, one minute before tourniquet, loose after a tourniquet for 3 minutes, 30 minutes after a tourniquet
ELISA μg/L
blood pressure
Time Frame: 2 hours in perioperative period
mmHg
Lac
Time Frame: One minute after the radial artery puncture, the tourniquet was applied for 1 hours and the tourniquet was released 3 minutes after the tourniquet release 30 minutes
blood gas analysis mmol/L
norepinephrine
Time Frame: One minute after the radial artery puncture, one minute after intubation, tourniquet application 1 hour, one minute before tourniquet, loose after a tourniquet for 3 minutes, 30 minutes after a tourniquet
ELISA nmol/L
cortisol
Time Frame: One minute after the radial artery puncture, one minute after intubation, tourniquet application 1 hour, one minute before tourniquet, loose after a tourniquet for 3 minutes, 30 minutes after a tourniquet
ELISA ng/ml
postoperative pain
Time Frame: hour 1、hour 6、hour 24、hour 48 after operation
VAS score
MDA
Time Frame: One minute after the radial artery puncture, one minute after intubation, tourniquet application 1 hour, one minute before tourniquet, loose after a tourniquet for 3 minutes, 30 minutes after a tourniquet
ELISA nmol/ml
Secondary Outcomes
- Complication of puncture(2 hours in perioperative period)