Effects of Attentional Focus Strategy on Dual-task Walking Training in Parkinson's Disease With and Without Freezing of Gait
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Mean step length from GAITRite
研究概览
简要总结
Walking deficits and altered brain capacity have been proved to be two of the main contributing factors in dual-task walking deficits in patients with Parkinson's disease (PD). In the past, patients with PD were usually suggested not to walk in dual-task conditions in order to concentrate on their walking performance better. However, since dual-task walking is really common in daily-life, this limitation usually lead to a decrease in quality of life for PD patients. In previous studies, effects of using attentional strategies in dual-task walking training remain unclear, while suitable attentional strategies and corresponded neuroplasticity for patients with and without freezing of gait have not been well discussed, either. Accordingly, this study is aimed to identify (1) whether internal or external attentional strategies is more ideal for PD patients with and without freezing of gait in dual-task walking training, and (2) changes in brain activity after receiving dual-task walking training with different attentional strategies in patients with or without freezing of gait. Our hypothesis are (1) patients with or without freezing of gait will react differently in dual-gait training with different attentional strategies, and (2) changes in brain activities will be different according to different attentional strategies given in the training.
详细描述
The hypothesis will be tested by gait performance, suprapostural tasks performance, relative power spectrum of EEG, and scales including MDS-UPDRS, ABC, BBS, and TUG.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •for PD patients:
- •(1) a diagnosis of idiopathic PD by a neurologist expert in movement disorders (2) onset age > 40 years old, (3) presence of gait disorders or freezing of gait (points on 3.10 in MDS-UPDRS>=1 or points on item 3 in NFOG-Q >0) (4) able to walk independently without an assistance device at least for 20 meters (5) without obvious action or postural tremor, according to the score of 3.15 and 3.16 (action and postural tremor of hands) in MDS-UPDRS
- •for healthy elders:
- •(1) without musculoskeletal of neurological diseases which may affect balance or walking performance (2) no medication that might influence their balance or cognition (3) MMSE> 26 points.
排除标准
- •for PD patients:
- •(1) with other neurological or musculoskeletal disease that might affect balance or walking (2) have a Mini-Mental State Examination (MMSE) < 27 points (3) have a history of brain surgery (4) have to modulate their medication for duration of the experiment.
结局指标
主要结局
Mean step length from GAITRite
时间窗: 60 minutes
gait performance
Amplitude from a triaxial accelerometer, X axes
时间窗: 25 minutes
motor suprapostural task performance
Step-to-step variability from GAITRite
时间窗: 60 minutes
gait performance
Amplitude from a triaxial accelerometer, Y axes
时间窗: 25 minutes
motor suprapostural task performance
Gait velocity from GAITRite
时间窗: 60 minutes
gait performance
Cadence from GAITRite
时间窗: 60 minutes
gait performance
Correct rate on working memory task
时间窗: 25 minutes
cognitive suprapostural task performance
Amplitude from a triaxial accelerometer, Z axes
时间窗: 25 minutes
motor suprapostural task performance
次要结局
- EEG relative power in the low gamma band(60 minutes)
- EEG relative power in the delta band(60 minutes)
- EEG relative power in the alpha band(60 minutes)
- EEG relative power in the theta band(60 minutes)
- EEG relative power in the beta band(60 minutes)