Skip to main content
Clinical Trials/NCT04364152
NCT04364152
Completed
Not Applicable

Effects of Attentional Focus Strategy on Dual-task Walking Training in Parkinson's Disease With and Without Freezing of Gait

National Taiwan University Hospital1 site in 1 country50 target enrollmentAugust 6, 2020

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Parkinson Disease
Sponsor
National Taiwan University Hospital
Enrollment
50
Locations
1
Primary Endpoint
Mean step length from GAITRite
Status
Completed
Last Updated
2 years ago

Overview

Brief Summary

Walking deficits and altered brain capacity have been proved to be two of the main contributing factors in dual-task walking deficits in patients with Parkinson's disease (PD). In the past, patients with PD were usually suggested not to walk in dual-task conditions in order to concentrate on their walking performance better. However, since dual-task walking is really common in daily-life, this limitation usually lead to a decrease in quality of life for PD patients. In previous studies, effects of using attentional strategies in dual-task walking training remain unclear, while suitable attentional strategies and corresponded neuroplasticity for patients with and without freezing of gait have not been well discussed, either. Accordingly, this study is aimed to identify (1) whether internal or external attentional strategies is more ideal for PD patients with and without freezing of gait in dual-task walking training, and (2) changes in brain activity after receiving dual-task walking training with different attentional strategies in patients with or without freezing of gait. Our hypothesis are (1) patients with or without freezing of gait will react differently in dual-gait training with different attentional strategies, and (2) changes in brain activities will be different according to different attentional strategies given in the training.

Detailed Description

The hypothesis will be tested by gait performance, suprapostural tasks performance, relative power spectrum of EEG, and scales including MDS-UPDRS, ABC, BBS, and TUG.

Registry
clinicaltrials.gov
Start Date
August 6, 2020
End Date
August 1, 2023
Last Updated
2 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • for PD patients:
  • (1) a diagnosis of idiopathic PD by a neurologist expert in movement disorders (2) onset age \> 40 years old, (3) presence of gait disorders or freezing of gait (points on 3.10 in MDS-UPDRS\>=1 or points on item 3 in NFOG-Q \>0) (4) able to walk independently without an assistance device at least for 20 meters (5) without obvious action or postural tremor, according to the score of 3.15 and 3.16 (action and postural tremor of hands) in MDS-UPDRS
  • for healthy elders:
  • (1) without musculoskeletal of neurological diseases which may affect balance or walking performance (2) no medication that might influence their balance or cognition (3) MMSE\> 26 points.

Exclusion Criteria

  • for PD patients:
  • (1) with other neurological or musculoskeletal disease that might affect balance or walking (2) have a Mini-Mental State Examination (MMSE) \< 27 points (3) have a history of brain surgery (4) have to modulate their medication for duration of the experiment.

Outcomes

Primary Outcomes

Mean step length from GAITRite

Time Frame: 60 minutes

gait performance

Amplitude from a triaxial accelerometer, X axes

Time Frame: 25 minutes

motor suprapostural task performance

Step-to-step variability from GAITRite

Time Frame: 60 minutes

gait performance

Amplitude from a triaxial accelerometer, Y axes

Time Frame: 25 minutes

motor suprapostural task performance

Gait velocity from GAITRite

Time Frame: 60 minutes

gait performance

Cadence from GAITRite

Time Frame: 60 minutes

gait performance

Correct rate on working memory task

Time Frame: 25 minutes

cognitive suprapostural task performance

Amplitude from a triaxial accelerometer, Z axes

Time Frame: 25 minutes

motor suprapostural task performance

Secondary Outcomes

  • EEG relative power in the low gamma band(60 minutes)
  • EEG relative power in the delta band(60 minutes)
  • EEG relative power in the alpha band(60 minutes)
  • EEG relative power in the theta band(60 minutes)
  • EEG relative power in the beta band(60 minutes)

Study Sites (1)

Loading locations...

Similar Trials