Frontal and Parietal Contributions to Proprioception and Motor Skill Learning
- Conditions
- Basic Science
- Registration Number
- NCT05739994
- Lead Sponsor
- Indiana University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria:<br><br> - Potential subjects must be between the ages of 18-45 years old and right-handed.<br><br> - We will only test right-handed individuals.<br><br> - We will only include individuals who report being free of Covid symptoms in week<br> preceding testing.<br><br>Exclusion Criteria:<br><br> - Current vision problems, other than needing glasses or contacts.<br><br> - Subjects will also be excluded if they currently suffer from frequent severe<br> headaches, glaucoma, heart or respiratory disease, hypertension, psychiatric<br> conditions, or learning or attention conditions.<br><br> - They will also be excluded for current or past: visual, hearing, or balance<br> impairments; stroke, seizure/epilepsy (including family history), or severe head<br> trauma; fainting; or diabetes.<br><br> - Subjects will be excluded for metal implants in the head other than titanium;<br> cochlear implants; implanted neurostimulator; cardiac pacemaker; intracardiac lines;<br> or a medication infusion device.<br><br> - Because TMS does not penetrate deeply into the head, we cannot test subjects whose<br> hair does not permit contact between the TMS coil and the scalp. We will therefore<br> exclude subjects with dreadlocks, weaves, or hair extensions.<br><br> - To protect the data from extraneous peripheral influences, we will also exclude<br> subjects who have had serious injury to the bones, joints, or muscles of either hand<br> or arm, and have not fully recovered. For the purpose of this study, fully<br> recovered means they no longer notice any pain, weakness, or loss of sensation in<br> the injured area, and have no mobility limitations.<br><br> - For the validity of our data, we will exclude subjects taking medications or drugs<br> that are known to affect cortical excitability and possibly seizure risk in an rTMS<br> study. These medications/drugs are (Rossi et al., 2009): imipramine, amitriptyline,<br> doxepine, nortriptyline, maprotiline, chlorpromazine, clozapine, foscarnet,<br> ganciclovir, ritonavir, amphetamines, cocaine, (MDMA, ecstasy), phencyclidine (PCP,<br> angel's dust), ketamine, gamma-hydroxybutyrate (GHB), theophylline, mianserin,<br> fluoxetine, fluvoxamine, paroxetine, sertraline, citalopram, reboxetine,<br> venlafaxine, duloxetine, bupropion, mirtazapine, fluphenazine, pimozide,<br> haloperidol, olanzapine, quetiapine, aripiprazole, ziprasidone, risperidone,<br> chloroquine, mefloquine, imipenem, penicillin, ampicillin, cephalosporins,<br> metronidazole, isoniazid, levofloxacin, cyclosporin, chlorambucil, vincristine,<br> methotrexate, cytosine arabinoside, BCNU, lithium, anticholinergics, antihistamines,<br> sympathomimetics.<br><br> - Participants will also be excluded if they have metallic, mechanical, or magnetic<br> implants; are claustrophobic, or are unable to remain still for long periods of<br> time; or use an intra-uterine device (IUD) whos MR compatibility has not been<br> established.<br><br> - Women who are pregnant or think they might be pregnant will also be excluded, as<br> effects of fMRI on the unborn are not known.<br><br> - People who have a BMI over 30 will be excluded as it may be uncomfortable or<br> impossible to lay in the MRI scanner.<br><br> - Potential subjects will be invited to reschedule if they would otherwise be eligible<br> (according to the initial screening), but the day of testing have drunk more than 3<br> units of alcohol or taken other recreational drugs in the 24 hour period prior to<br> testing; have had more than 3 cups of coffee in the last hour; are sleep deprived<br> (<4 hours sleep the previous night); or have participated in another brain<br> stimulation experiment the same day. These are standard in the TMS literature to<br> protect the validity of the data and keep seizure risk minimal. In addition, we will<br> invite invite subjects to reschedule if they have any of the common Covid symptoms<br> within the last week. If they don't believe they can meet these criteria on another<br> date, they will be excluded.<br><br> - After giving their consent, participants may be excluded during or after the<br> familiarization session if they are unable to perform the tasks or follow<br> instructions, or if their TMS stimulation parameters cannot be reliably determined<br> by the experimenter, or if TMS is not well tolerated.
Not provided
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Motor skill;Proprioception
- Secondary Outcome Measures
Name Time Method