NCT02707536
Completed
N/A
Influence of Platelet-Rich Fibrin on Post-extraction Alveolar Ridge Healing/Preservation as a Stand-alone or Adjunct to Particulate Graft: A Clinical, Radiographic and Histological Evaluation
The University of Texas Health Science Center, Houston1 site in 1 country42 target enrollmentMay 2014
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Extraction Socket Healing
- Sponsor
- The University of Texas Health Science Center, Houston
- Enrollment
- 42
- Locations
- 1
- Primary Endpoint
- Change in alveolar ridge width (buccal-lingual)
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
The goal of this project is to evaluate the influence of platelet rich fibrin (PRF) in extraction socket healing with or without particulate bone graft. The hypothesis of this study is that PRF will enhance the extraction socket healing and new bone formation when compared to extraction sockets grafted without PRF.
Investigators
Sridhar V. K. Eswaran
Assistant Professor
The University of Texas Health Science Center, Houston
Eligibility Criteria
Inclusion Criteria
- •Subjects ≥ 18 years of age
- •Hopeless or non-restorable single non-molar tooth per quadrant with adjacent teeth present
- •Maximum of two teeth can qualify per patient.
- •The buccal plate must be ≥ 1mm in width with a 4-wall configuration.
- •Cases requiring minimal sinus grafting (\<3mm)
- •Bone grafting limited to the apical portion of the osteotomy site
Exclusion Criteria
- •Exclusion Criteria:
- •Untreated periodontal disease, endodontic-periodontal disease and/or caries
- •The buccal plate must be ≤ 3mm in width with a 4-wall configuration.
- •Patients with uncontrolled or severe systemic disease (Diabetes)
- •Patients with medical conditions or taking medication associated with compromised bone healing (Diabetes, Autoimmune Dysfunction, Prolonged Cortisone Therapy, Chemotherapy, or Bisphosphonate Therapy)
- •Current Smokers
- •Subjects with extensive parafunctional habits (ie; bruxism)
- •Subjects who demonstrate inadequate oral hygiene
Outcomes
Primary Outcomes
Change in alveolar ridge width (buccal-lingual)
Time Frame: baseline, 3 months
Baseline is at the time of extraction with or without socket grafting.
Change in alveolar ridge height (apical coronal)
Time Frame: baseline, 3 months
Baseline is at the time of extraction with or without socket grafting.
Secondary Outcomes
- Percentage of residual bone graft in bone core as assessed histology(3 months)
- Percentage of vital bone in bone core as assessed histology(3 months)
Study Sites (1)
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