NCT02707536已完成不适用
Influence of Platelet-Rich Fibrin on Post-extraction Alveolar Ridge Healing/Preservation as a Stand-alone or Adjunct to Particulate Graft: A Clinical, Radiographic and Histological Evaluation
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 42
- 试验地点
- 2
- 主要终点
- Change in alveolar ridge width (buccal-lingual)
研究概览
简要总结
The goal of this project is to evaluate the influence of platelet rich fibrin (PRF) in extraction socket healing with or without particulate bone graft. The hypothesis of this study is that PRF will enhance the extraction socket healing and new bone formation when compared to extraction sockets grafted without PRF.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subjects ≥ 18 years of age
- •Hopeless or non-restorable single non-molar tooth per quadrant with adjacent teeth present
- •Maximum of two teeth can qualify per patient.
- •The buccal plate must be ≥ 1mm in width with a 4-wall configuration.
- •Cases requiring minimal sinus grafting (<3mm)
- •Bone grafting limited to the apical portion of the osteotomy site
排除标准
- •Exclusion Criteria:
- •Untreated periodontal disease, endodontic-periodontal disease and/or caries
- •The buccal plate must be ≤ 3mm in width with a 4-wall configuration.
- •Patients with uncontrolled or severe systemic disease (Diabetes)
- •Patients with medical conditions or taking medication associated with compromised bone healing (Diabetes, Autoimmune Dysfunction, Prolonged Cortisone Therapy, Chemotherapy, or Bisphosphonate Therapy)
- •Current Smokers
- •Subjects with extensive parafunctional habits (ie; bruxism)
- •Subjects who demonstrate inadequate oral hygiene
结局指标
主要结局
Change in alveolar ridge width (buccal-lingual)
时间窗: baseline, 3 months
Baseline is at the time of extraction with or without socket grafting.
Change in alveolar ridge height (apical coronal)
时间窗: baseline, 3 months
Baseline is at the time of extraction with or without socket grafting.
次要结局
- Percentage of residual bone graft in bone core as assessed histology(3 months)
- Percentage of vital bone in bone core as assessed histology(3 months)
研究者
Sridhar V. K. Eswaran
Assistant Professor
The University of Texas Health Science Center, Houston
研究点 (2)
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