PBMT on Muscular Performance and Recovery in Different Time-points

Not Applicable

Completed

• Conditions: Phototherapy
• Interventions: Device: Photobiomodulation Therapy (PBMT)

• Registration Number: NCT03420391
• Lead Sponsor: University of Nove de Julho

Brief Summary

Recent studies with photobiomodulation therapy (PBMT) have shown positive results delaying skeletal muscle fatigue and improving the status of biochemical markers related to skeletal muscle damage when these therapies were applied before exercise. The aim of this project is to verify the effects of PBMT in improvement of skeletal muscle performance and skeletal muscle recovery in healthy male subjects. This project aim also to validate the concept that simultaneous use of three wavelengths and light sources lead to optimized action independently of time-window between irradiation and the exercise.

Detailed Description

This is a randomized, triple-blinded, placebo-controlled trial. Sixty healthy untrained male subjects will be randomly allocated to six experimental groups: Placebo, Control, PBMT 5 mins, PBMT 3h, PBMT 6h and PBMT 24 hours. PBMT will be applied precisely two minutes after baseline MVC test. Then, after five minutes, 3, 6 hours or 1 day (24 hours) of PBMT the eccentric exercise protocol will be performed. We will analyze maximum voluntary contraction (MVC), creatine kinase (CK) activity and delayed onset muscle soreness (DOMS). Assessments will be performed at baseline, immediately after (1 minute), 1 hour, 24 and 48 hours after the eccentric exercise protocol.

Study Timeline

• Study First Submitted: 2018-01-20
• Study First Submitted QC: 2018-01-27
• Study First Posted: 2018-02-05
• Study Start: 2019-05-20
• Primary Completion: 2019-07-19
• Study Completion: 2019-07-19
• Status Verified: 2020-04
• Last Update Submitted: 2020-04-27
• Last Update Posted: 2020-04-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 60

Inclusion Criteria

• Healthy
• not athletes or who engage in physical activity at most once a week
• Individuals should not present a history of musculoskeletal injury in the hip and knee regions in the two months prior to the studies
• they should not be using pharmacological agents and / or nutritional supplements
• They must attend 100% of the data collections.

Exclusion Criteria

• Individuals who do not meet the criteria mentioned above or who present musculoskeletal damage during collection were excluded from the study.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
3 Hours	Photobiomodulation Therapy (PBMT)	3 hours: Participants will be performed the eccentric exercise protocol 3 hours after PBMT. Assessments will be performed before at baseline, 1 minute, 1 hour and 24, 48 hours after the end of exercise protocol.
24 hours	Photobiomodulation Therapy (PBMT)	24 hours: Participants will be performed the eccentric exercise protocol 24 hours after PBMT. Assessments will be performed before at baseline, 1 minute, 1 hour, 24 and 48 hours after the end of exercise protocol.
Placebo PBMT	Photobiomodulation Therapy (PBMT)	Participants will be treated with placebo PBMT in different time-points before the eccentric exercise protocol (5 minutes, 3 hours, 6 hours or 24 hours). Assessments will be performed at baseline, 1 minute, 1 hour, 24 and 48 hours after the end of exercise protocol.
5 Minutes	Photobiomodulation Therapy (PBMT)	Participants will be performed the eccentric exercise protocol 5 minutes after PBMT. Assessments will be performed at baseline, 1 minute, 1 hour, 24 and 48 hours after the end of exercise protocol.
6 Hours	Photobiomodulation Therapy (PBMT)	6 hours: Participants will be performed the eccentric exercise protocol 6 hours after PBMT. Assessments will be performed at baseline, 1 minute, 1 hour, 24 and 48 hours after the end of exercise protocol.

Primary Outcome Measures

Name	Time	Method
Torque peak / maximum voluntary contraction - MVC	1 minute, 1 hour, 24 and 48 hours after the end of exercise protocol.	Assessment was performed in the isokinetic dynamometer (System 4, Biodex®, USA)

Secondary Outcome Measures

Name	Time	Method
Delayed onset muscle soreness (DOMS)	1 minute, 1 hour, 24 and 48 hours after the end of exercise protocol.	Assessment was performed through visual analogue scale (VAS). A visual analogue scale (VAS) of 100 mm was used as a self-rating of volunteers DOMS intensity, with assistance of a blinded researcher, where "0" corresponds to no pain and 100mm corresponds to the worst pain possible.
Biochemical marker of muscle damage	1 minute, 1 hour, 24 and 48 hours after the end of exercise protocol.	Analysis of Creatine Kinase (CK) levels

Trial Locations

Locations (1)

Universidade Nove de Julho; 🇧🇷 São Paulo, Brazil