Knee Joint Contractures: Reversibility and Molecular Pathways
Trial Snapshot
- Phase
- Not Applicable
- Status
- Withdrawn
- Locations
- 1
- Primary Endpoint
- development of contracture post total knee arthroplasty
Study Overview
Brief Summary
A contracture is a pathological condition limiting range and function of joints. Contractures of large and small joints alike will affect one's ability to independently perform daily activities such as eating, dressing or walking. Current treatments for contractures include physical stretching, the use of assistive devices or, rarely, surgery. Despite prolonged treatments, patients with contractures rarely regain complete mobility. Progress in preventing and treating contractures will be possible only through an understanding of the biological and molecular processes involved. Our group has established and validated an animal model to study the histological events and the molecular mechanisms involved in joint contractures. We have provided evidence for capsule stiffness, characterized cartilage degeneration, and identified four genes whose expression is altered in the cartilage of a knee joint with contracture. The work we propose in the current study aims at finding genes and pathways in the joint capsule associated with knee joint contractures. The results will identify new avenues for treating the large number of patients suffering from contractures.
Detailed Description
We propose to constitute a bank of capsule samples from people with osteoarthritis undergoing primary total knee arthroplasty. It is expected that about 1.3% of people will develop a contracture post arthroplasty. A second sample will be taken from those that require surgery for release of contracture or revision. We will study histological characteristics and compare gene expression between the primary sample and the contracture sample in the same patient. In order to determine whether intrinsic genetic factors influence the develpment of joint contractures in the osteoarthritis population, all specimens will be analyzed for differential gene expression between patients with and without knee contractures post arthroplasty.
The remaining capsule tissue not used for this study will be banked and made available to other researchers.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Retrospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Osteoarthritis, booked for a total knee arthroplasty
Exclusion Criteria
- •Transmissible disease (e.g., HIV infection, hepatitis B or C)
- •Suspected neoplasia
- •Suspected infection (which can cause arthrofibrosis)
- •Hypertrophic scarring
Outcomes
Primary Outcomes
development of contracture post total knee arthroplasty
Time Frame: Within 1 year
1.3% of subjects are expected to develop a contracture post toal knee arthroplasty within a year of the surgery.
Secondary Outcomes
No secondary outcomes reported
Investigators
Dr. Guy Trudel
Researcher
Ottawa Hospital Research Institute