Diagnosis of Active and Latent TB Infection With IFN-y Assays in African Children
- Conditions
- Tuberculosis
- Registration Number
- NCT00456469
- Lead Sponsor
- Liverpool School of Tropical Medicine
- Brief Summary
Study based in Southern Ethiopia Purpose - to explore if children in contact with adults with TB have positive acute reactants such as IFN-y and other cytokine responses; if these responses discriminate between high and low risk of disease progression and whether these could be incorporated into improved diagnostic approaches.
- Detailed Description
The study follows children in contact with TB. Those with positive TST will be offered chemoprophylaxis and all children will be followed for 2 years to describe IFN-y responses over time, identify symptoms of active TB and if these symptoms are associated with IFN-y and other cytokine responses.
Children with suspicion of TB attending health centres will also be investigated using routine diagnostic tests and IFN-y and other cytokines responses to evaluate if the latter could be used in improved diagnostic approaches.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 500
- Children - 1 to 14 years old in contact with adults with smear positive TB
Or:
- Children with suspicion of TB admitted to the hospital for investigations
- Residency > 10 Km from recruitment center
Or:
- Patient severely to undergo diagnostic procedures.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Bushullo Major Health Centre
🇪🇹Awassa, Southern Region, Ethiopia