Role of Activin A (ActA) in the Human Cancer Cachexia
Not Applicable
Completed
- Conditions
- Colorectal CancerLung Cancer
- Interventions
- Other: blood tests and muscular biopsies
- Registration Number
- NCT01604642
- Lead Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
- Brief Summary
The goal of the investigators study is to investigate the role of a hormone named Activin A (ActA) in the development of the skeletal muscle atrophy caused by cancer. According to the investigators hypothesis, ActA could be released by the tumor and activate a muscle atrophy gene program. To answer this question, the investigators plan first to compare circulating levels of ActA in cancer patients with and without cachexia. In a second step, the investigators would like to assess whether ActA circulating levels are predictive for the development of cachexia and short survival.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 150
Inclusion Criteria
- 18-year-old or older
- Colorectal or lung cancer demonstrated by histology or cytology
- New diagnosis or new recurrence
- Expected survival more than 3 months
- No previous history of other cancer in the last 5 years
- No pregnancy or lactation
- Signed informed consent
Exclusion Criteria
- Non-caucasian
- Major digestive malabsorption
- Major depression
- Artificial nutrition
- Height doses of steroids (>1 mg/kg hydrocortisone equivalent)
- Hyperthyroidism
- Other causes of malnutrition
- Expected survival less than 3 months
- Severely impaired walking
- Anticoagulants or antiplatelet therapy
- Disability or medical condition which might prevent the compliance to the protocol
- Any conditions which may prevent the compliance to the protocol
- Performance status ECOG > ou = 4
- Participation to other clinical studies
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description cachectic versus no cachectic patients blood tests and muscular biopsies blood tests, muscular biopsies
- Primary Outcome Measures
Name Time Method Circulating Activin A level 2 years
- Secondary Outcome Measures
Name Time Method Body composition measured by bioimpedance 2 years Muscle strength as measured by grip strength 2 years Quality of life as assessed using the QLQ-C30 2 years Dietary assessment measured by SNAQ score and 3-Day intake 2 years Body mass index 2 years Mid arm muscle circumference calculated by the triceps skinfold and the mid arm circumference 2 years
Trial Locations
- Locations (1)
Cliniques Universitaires Saint-Luc
🇧🇪Brussels, Belgium